Special Issue ‘Viral Infection and Autoimmune Diseases’

Nakamura, Hideki; Takei, Masami

doi:10.3390/v14112491

Cited by 3 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed causal relationship between critical COVID-19 and increased susceptibility to celiac disease illuminates the multifaceted consequences of viral infections on the immune system and autoimmune disorders [30]. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, has been shown to exert profound effects on lymphocytes [31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study

Zou,

Pan,

Zhou

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Celiac disease exhibits a higher prevalence among patients with coronavirus disease 2019. However, the potential influence of COVID-19 on celiac disease remains uncertain. Considering the significant association between gut microbiota alterations, COVID-19 and celiac disease, the two-step Mendelian randomization method was employed to investigate the genetic causality between COVID-19 and celiac disease, with gut microbiota as the potential mediators. We employed the genome-wide association study to select genetic instrumental variables associated with the exposure. Subsequently, these variables were utilized to evaluate the impact of COVID-19 on the risk of celiac disease and its potential influence on gut microbiota. Employing a two-step Mendelian randomization approach enabled the examination of potential causal relationships, encompassing: 1) the effects of COVID-19 infection, hospitalized COVID-19 and critical COVID-19 on the risk of celiac disease; 2) the influence of gut microbiota on celiac disease; and 3) the mediating impact of the gut microbiota between COVID-19 and the risk of celiac disease. Our findings revealed a significant association between critical COVID-19 and an elevated risk of celiac disease (inverse variance weighted [IVW]: P = 0.035). Furthermore, we observed an inverse correlation between critical COVID-19 and the abundance of Victivallaceae (IVW: P = 0.045). Notably, an increased Victivallaceae abundance exhibits a protective effect against the risk of celiac disease (IVW: P = 0.016). In conclusion, our analysis provides genetic evidence supporting the causal connection between critical COVID-19 and lower Victivallaceae abundance, thereby increasing the risk of celiac disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study

Zou,

Pan,

Zhou

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Most symptoms of long‐COVID‐19 syndrome are debilitating but not fatal 8 ; however, some sequelae can be serious and require medical care. COVID‐19 affects both the innate and adaptive immune systems; indeed, virus‐triggered hyperactivation of helper T cells and antigen‐presenting cells causes dysfunction of various organs and systems 4,6,9 . SARS‐CoV2 mutates quickly, resulting in the rapid emergence of variants, each of which may interact with the immune system in different ways 10 …”

Section: Discussionmentioning

confidence: 99%

“…COVID-19 affects both the innate and adaptive immune systems; indeed, virus-triggered hyperactivation of helper T cells and antigen-presenting cells causes dysfunction of various organs and systems. 4,6,9 rapid emergence of variants, each of which may interact with the immune system in different ways. 10 A study in Hong Kong showed that the risk of pernicious anemia, SpA, RA, other autoimmune arthritis, psoriasis, pemphigoid, Graves' disease, anti-phospholipid antibody syndrome, immune-mediated thrombocytopenia, multiple sclerosis, and vasculitis was significantly higher in patients with COVID-19 than in those without.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study from Hong Kong reported that COVID‐19 increased the risk of developing autoimmune inflammatory rheumatic diseases (AIRDs) such as rheumatoid arthritis (RA), spondyloarthritis (SpA), and vasculitis 5 ; however, the hazard ratio (HR) for AIRDs such as systemic lupus erythematosus (SLE), primary Sjogren's syndrome (pSS), and systemic sclerosis (SSc) did not increase significantly in those with COVID‐19 5 . Viral infection, a known environmental trigger, can cause AIRDs through several mechanisms, including molecular mimicry, epitope spreading, and bystander activation 6 ; however, additional clinical data are required to clarify the association between infection by SARS‐CoV‐2 and the occurrence of AIRDs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence if autoimmune inflammatory rheumatic diseases after COVID‐19 in South Korea: A nationwide cohort study based on health insurance data

Lee,

Kim,

Jeon

et al. 2024

Int J of Rheum Dis

View full text Add to dashboard Cite

Many medical issues have arisen in the wake of the coronavirus disease 2019 (COVID-19) pandemic, which was caused by SARS-CoV-2.The risk of thromboembolism increased after SARS-CoV-2 infection, as did the mortality rate. [1][2][3] Moreover, SARS-CoV-2 infection has many sequelae, including immune, nervous, cardiac, respiratory, renal, musculoskeletal, and gastrointestinal abnormalities. 4 A recent study from Hong Kong reported that COVID-19 increased the risk of developing autoimmune inflammatory rheumatic diseases (AIRDs) such as rheumatoid arthritis (RA), spondyloarthritis (SpA), and vasculitis 5 ; however, the hazard ratio (HR) for AIRDs such as systemic lupus erythematosus (SLE), primary Sjogren's syndrome (pSS), and systemic sclerosis (SSc) did not increase significantly in those with COVID-19. 5 Viral infection, a known environmental trigger, can cause AIRDs through several mechanisms, including molecular mimicry, epitope spreading, and bystander activation 6 ; however, additional clinical data are required to clarify the association between infection by SARS-CoV-2 and the occurrence of AIRDs.Here, we used Korean National Health Insurance Service (NHIS) data to compare the incidence of AIRDs between those with a diagnosis of COVID-19 and those without. | MATERIAL S AND ME THODS | Data source and the study populationReimbursement claims data were obtained from the Korean NHIS database; the NHIS covers 97.2% of the Korean population. The National Health Information Database collects NHIS data, including all healthcare-related information such as health screening, socioeconomic and demographic variables, mortality data, diagnoses, and associated procedures and prescriptions, all of which are identified using the International Classification of Diseases, Tenth Revision (ICD-10) codes, as well as Korean Drug and Anatomical Therapeutic Chemical Codes for the entire population. 7 Data from patients who were tested for COVID-19 by RT-PCR (nasal or pharyngeal swabs) from January 2020 to December 2021 were extracted from the NHIS database (approval no. NHIS-2023-1-479) and then divided into COVID-19 PCR (+) and (−) groups. Participants who had ICD-10 codes for AIRDs prior to the COVID-19 PCR assay, or lacked demographic data, were excluded. The index date was the day on which the COVID-19 PCR test was performed, and the end of the follow-up was dated as follows: (1) March 31, 2022, (2) the date on which the first ICD-10 code for AIRDs was issued, or (3) the expired date. In the case of multiple AIRDs codes, the first AIRD code date was taken as the end of follow-up. When individual subjects had undergone multiple COVID-19 PCR assays, the first COVID-19 PCR assay date was used as the index date for the COVID-19 PCR (−) group, and the date of the positive COVID-19 PCR test was used for the COVID-19 PCR (+) group. When the participant was negative for COVID-19 PCR initially and then converted to positive in the latter COVID-19 PCR test, this participant was included in the COVID-19 PCR (+) group, and the index date was ...

show abstract

“…The reactivation of HSV-1 triggers a range of antiviral responses, potentially leading to the disruption of immune homeostasis [42]. An increasing number of researchers are displaying heightened interest in investigating the effects of viruses on autoimmune diseases [43], thereby opening up new avenues for future research into the underlying mechanisms of autoimmune disorders.…”

Section: Discussionmentioning

confidence: 99%

Harnessing the Potential of Exosomal miRNAs: A Breakthrough in Rheumatoid Arthritis Diagnosis and Monitoring

Gong,

Zhang,

Khan

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Rheumatoid arthritis (RA) is an autoimmune disorder characterized by the inflammation-induced joint damage. Timely diagnosis and treatment are crucial to prevent lasting disability. Here, we aim to evaluate whether exosomal miRNAs could serve as promising biomarkers for expeditious RA diagnosis and effective therapy. Methods First, we performed small RNA sequencing to determine the miRNA profiles of serum exosomes within a screening cohort comprising 18 untreated active RA patients, along with 18 age and gender-matched healthy controls. Subsequently, the miRNA profiles were then validated in a training cohort consisting of 24 RA patients and 24 healthy controls, using RT-qPCR methodology. Finally, the selected exosomal miRNAs were subjected to validation in a larger cohort comprising 108 RA patients and 103 healthy controls. The diagnostic efficacy of the exosomal miRNAs was evaluated by receiver operating characteristic (ROC) curve analysis. The biological functions of the miRNAs were determined by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Results Our results first demonstrated a noteworthy upregulation of three specific miRNAs (miR-885-5p, miR-6894-3p, and miR-1268a) in the serum exosomes of patients of RA patients as compared with healthy controls. The combination of three miRNAs along with Anti-Cyclic Citrullinated Peptide Antibodies (ACPA) exhibited excellent diagnostic accuracy, yielding an area under the curve (AUC) of 0.963 (95% confidence interval = 0.941–0.984), a sensitivity of 87.96%, and a specificity of 93.20%. Notably, miR-885-5p exhibited remarkable discriminatory capacity by itself indistinguishing ACPA- negative RA patients from healthy controls, with an AUC of 0.993 (95% CI = 0.978-1), a sensitivity of 96.67%, and a specificity of 100%. Moreover, in the assessment of therapeutic effectiveness, the expression of miR-1268a displayed a significant reduction on the 29th day of MTX treatment in RA patients. This decline in expression paralleled the trends observed in TJC28 (28-joint tender count), SJC28 (28-joint swollen count), and DAS28-CRP (Disease Activity Score with 28-joint count using C-Reactive Protein), all of which are indicative of RA disease activity. Finally, predictive analysis indicated that all three exosomal miRNAs target pivotal signaling molecules involved in inflammatory pathways, thereby demonstrating effective modulation of the immune system. Conclusions In this study, we have successfully demonstrated the promising potential of serum exosomal miRNAs, particularly miR-885-5p, miR-6894-3p and miR-1268a, hold promising potential as biomarkers for the early diagnosis and prediction of RA for the first time. These findings highlight the importance of exosomal miRNAs in the realm of RA diagnosis and disease monitoring.

show abstract

Special Issue ‘Viral Infection and Autoimmune Diseases’

Abstract: Viral infection, which is one of the environmental factors, and human autoimmune diseases are often associated with each other [...]

Cited by 3 publications

References 6 publications

Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study

Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study

Incidence if autoimmune inflammatory rheumatic diseases after COVID‐19 in South Korea: A nationwide cohort study based on health insurance data

Harnessing the Potential of Exosomal miRNAs: A Breakthrough in Rheumatoid Arthritis Diagnosis and Monitoring

Contact Info

Product

Resources

About