Specialized biobank for Diabetes Research: current prospect

Abstract

The exponential increase in human population depicted by the recent population trend shows that every 15 years the world population would increase by at least 1 billion. Consequently, there is a large increase in the use of human biospecimens for academic and pharmaceutical research. The global demand for human biospecimen is estimated to be worth $700 million and projected to increase 20%-30% annually. Biospecimens and associated data sharing are essential for biomedical research findings, discovery of disease markers, and improving patients' health care. One of the most prevalent chronic diseases worldwide that involves extensive interdisciplinary research-based studies is diabetes. In this review, we emphasized the need and importance of biobanks in diabetes, which will serve as a resource to promote research in understanding disease link, and mechanisms related to molecular pathways, protein and drug targets, and also in improving health outcomes.

Intracellular Amyloid-β Detection from Human Brain Sections Using a Microfluidic Immunoassay in Tandem with MALDI-MS

“…However, the soluble Aβ species that can localize intracellularly are among the likely culprits for cognitive impairment and neurotoxicity in AD pathogenesis. ,,,, A wealth of data are available about Aβ through in vitro studies and animal models; however, given the complexity of the human nervous system, the assessment of Aβ in the human brain can provide information more relevant to human AD. Clinically annotated human brain samples from tissue banks represent a golden opportunity to perform such studies. − …”