Background
Real-world data on outcomes of patients with newly diagnosed Crohn’s Disease (ndCD) is limited. We aimed to assess the achievement of corticosteroid-free clinical-remission (CS-free-CR) and other therapeutic targets one-year after diagnosis in a cohort of patients with ndCD treated by a multidisciplinary team (MDT).
Methods
A prospective observational cohort study was conducted on consecutive treatment-naïve adults with ndCD. Patients received management at the treating physician’s discretion, along with a tailored nutritional plan provided by an IBD-oriented dietitian. Patients were guided and educated by an IBD-nurse, with flexible communication access to the IBD team. Therapeutic targets were assessed at one-year. Multivariable logistic regression was used to evaluate predictors of CS-free-CR.
Results
Seventy-six patients (50% female) with a median age of 27 (22-39) years were eligible. Over 75% of patients were assessed by IBD oriented dietitians and the IBD nurse. Within a median of 4.3 (2.5-6.7) months from diagnosis 60.5% initiated biologics (96% anti-TNF). Dietary intervention was applied to 77.6% of the cohort, either monotherapy (33.9%) or add-on (66.1%). At one-year, 64.5% of patients achieved sustained CS-free-CR, 56.6% biochemical remission, 55.8% endoscopic response, 44.2% endoscopic remission, 30.8% deep remission and in 39.5% there was an improvement in health-related-quality-of-life (HRQoL). Predictors for CS-free CR were uncomplicated phenotype (B1/P0), lower BMI, and lower patient-reported outcome (PRO-2) scores at diagnosis.
Conclusions
In a real-world setting at a tertiary medical center, a cohort of ndCD patients treated by a MDT resulted in favorable one-year outcomes. Over 60% achieved CS-free-CR, along with significant improvements in biomarkers and HRQoL.