Evolutionary genetic polymorphism which is to preserve individual genetic information in the human genome throughout the development of the body is considered. The genetic portrait of an individual should be taken as the basis for the development of personalized nutrition for athletes which ensures its effectiveness, the possibility of effective prevention and comprehensive treatment of possible sports pathologies. New prescription formulas of isotonic and hypotonic sports nutrition drinks using polyprenols (PP) isolated from needles of woody plants have been developed. PP are added in the amount of 6.7 mg / 250 cm3 of drink. The isotonic properties of the drink are determined by the content of vitamins E, B1, B6, niacin and C and hypotonic properties are due to vitamins B1, B6, B12, folic and pantothenic acids. Immunomodulating antioxidant and regenerative properties of PP based on available studies are shown, which are important in improving the performance and adaptation of athletes to physical and emotional stress. The advantage of the developed technologies is the synergism of the action of active ingredients at optimal dosages and the presence of high efficiency, the absence of adverse reactions and safety during prolonged use in various age groups of athletes.