“…14,104,105 Possible improvements from more specialised care for patients with TBI may reflect more concentrated knowledge among health professionals, and greater numbers of patients. 14,106 However, a common concern is that the evidence base on alterative locations of care following TBI is weak; in the absence of RCTs, confounding is a key concern, and previous studies have failed to undertake adequate risk-adjustment when comparing outcomes across settings. Further, few studies have compared the relative costs and cost-effectiveness of alternative locations of care following acute TBI.…”