Speciation analysis of manganese against the background of its different content in the blood serum of dairy cows

Нотова, С. В.; Лебедев, С. В.; Маршинская, О. В.; Казакова, Т. В.; Ajsuvakova, Olga P.

doi:10.1007/s10534-022-00456-8

Cited by 3 publications

(2 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hereford cattle manganese accumulation Rahil-Khazen et al, 2002;Taylor, 1996). In the same time, recent work demonstrated that manganese distribution in dairy cow organisms depends on element status and Mn redistribution may occur when general Mn supply and digestion change (Notova et al, 2023). Thus, the results of the works similar to the present one and meta-analysis of works obtained by the example of different locations may be used for understanding general patterns on Mn distribution depending on elemental status of cattle and control its supply.…”

Section: Discussionsupporting

confidence: 54%

Specific of accumulation of manganese in organs and tissues of Hereford cattle

Narozhnykh,

Petukhov,

Syso

et al. 2024

Braz. J. Biol.

View full text Add to dashboard Cite

The elemental status of cattle is one of the important factors, which determine its growth, fertility, fetal development, meat and dairy production, etc. Therefore, the study of content of different elements in cattle organs and tissues and its correlation with cattle characteristics and diet is urgent task. It is also important to develop intravital and low-invasive methods to analyze element content in cattle to regulate its diet during lifetime. In the present work, we have studied the content and distribution of manganese in Hereford cattle from an ecologically clean zone of Western Siberia (Russia). 252 samples were taken from 31 bulls aged 15-18 months. They were collected from various livestock farms in the region and analyzed using atomic absorption spectrophotometry (organs and muscle tissue) and inductively coupled plasma atomic emission spectrometry (hair). The median values of manganese concentration obtained in natural moisture for hair, heart, kidneys, liver, lungs, muscles, spleen, testes, and brain were 25, 0.37, 1.0, 2.6, 0.4, 0.2, 0.4, 0.5, and 0.5 ppm. Accordingly, the concentration of manganese differs significantly in the organs and tissues of animals (H = 188.6, df = 8, p <0.0001). Statistically significant associations of manganese were revealed in pairs: liver-testis, hair-testis, spleen-testis, and heart-brain. The classification of organs and tissues of animals according to the level of content and variability of manganese is carried out. The concentration of manganese in the body is not uniform, most of all it is deposited in the hair and excretory organs of the liver and kidneys. In other organs and muscle tissues, the distribution of manganese is more even and is in the range of 0.2-0.5 ppm. The resulting ranges can be used as a guideline for Hereford cattle bred in Western Siberia.

show abstract

Section: Discussionsupporting

confidence: 54%

Specific of accumulation of manganese in organs and tissues of Hereford cattle

Narozhnykh,

Petukhov,

Syso

et al. 2024

Braz. J. Biol.

View full text Add to dashboard Cite

show abstract

“…Based on comparisons with commercial standards, two peaks were assigned to α2-macroglobulin (tetrameric and dimeric, containing both Zn and Cu), one to caeruloplasmin (Cu only), one to albumin (containing both Zn and Cu), and the last one to LMW species (<1% Cu; 3% Zn). A similar approach was also applied to Mn speciation in bovine serum, finding six peaks presumed to correspond to various forms of α2-macroglobulin, transferrin and/or albumin, and LMW species, with the latter making up about half of the Mn speciation [122].…”

Section: Human Plasma Bovine Serum Bovine Albuminmentioning

confidence: 99%

Recent Advances in Metalloproteomics

Coverdale,

Polepalli,

Arruda

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Interactions between proteins and metal ions and their complexes are important in many areas of the life sciences, including physiology, medicine, and toxicology. Despite the involvement of essential elements in all major processes necessary for sustaining life, metalloproteomes remain ill-defined. This is not only owing to the complexity of metalloproteomes, but also to the non-covalent character of the complexes that most essential metals form, which complicates analysis. Similar issues may also be encountered for some toxic metals. The review discusses recently developed approaches and current challenges for the study of interactions involving entire (sub-)proteomes with such labile metal ions. In the second part, transition metals from the fourth and fifth periods are examined, most of which are xenobiotic and also tend to form more stable and/or inert complexes. A large research area in this respect concerns metallodrug–protein interactions. Particular attention is paid to separation approaches, as these need to be adapted to the reactivity of the metal under consideration.

show abstract

Effect of subchronic exposure to manganese on mineral metabolism in Wistar rats

Kazakova,

Marshinskaia,

Notova

2024

Acta biomedica scientifica

Self Cite

View full text Add to dashboard Cite

Background. The presence of increased manganese concentrations in soils and water intakes areas for drinking and household purposes in a number of the Russian Federation subjects indicates the chronic influence of this metal on all segments of the population. This situation is aggravated by violation of the optimal nutrition principles, which leads to changes in the organism absorption of micronutrients. In this regard, the study of the elemental status of an organism against the background of manganese exposure is of particular importance.The aim. To study the effects of subchronic exposure to manganese on the mineral status of Wistar rats.Materials and methods. To conduct the study, 20 mature rats were selected, from which two groups were formed – control (n = 10) and experimental (n = 10). Animals in the control group received a general diet, animals in the experimental group received a diet with additional administration of manganese sulfate at a dose of 1433 mg/kg for 28 days. At the end of the preparatory period, blood and brain samples were taken to determine the content of chemical elements using inductively coupled plasma mass spectrometry and of metal-ligand manganese forms using high-performance liquid chromatography combined with inductively coupled plasma mass spectrometry.Results. It has been established that subchronic oral exposure to manganese leads to an increase in the content of this microelement in the blood serum and to a decrease in the levels of calcium, potassium, magnesium, iron and copper. In the cerebral cortex, the level of manganese, lead, mercury and strontium increases against the background of a decrease in iron and iodine levels. An increase in the gross content of manganese in blood serum leads to an overload of the main high-molecular carriers and initiates the formation of low-molecular forms of manganese.Conclusion. Subchronic oral exposure to manganese leads to the accumulation of this microelement in the body of animals and to the development of an imbalance of a number of macro- and microelements.

show abstract

Speciation analysis of manganese against the background of its different content in the blood serum of dairy cows

Cited by 3 publications

References 68 publications

Specific of accumulation of manganese in organs and tissues of Hereford cattle

Specific of accumulation of manganese in organs and tissues of Hereford cattle

Recent Advances in Metalloproteomics

Effect of subchronic exposure to manganese on mineral metabolism in Wistar rats

Contact Info

Product

Resources

About