Species and individual differences and connectional asymmetry of Broca's area in humans and macaques

Xia, Xiaoluan; Gao, Fei; Yuan, Zhen

doi:10.1016/j.neuroimage.2021.118583

Cited by 10 publications

(7 citation statements)

References 107 publications

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“…These include conceptual categorization, semantic processing, and language processing 32,33 . Previous MRI studies have shown that the SC in areas 44, 45A, and 45B in macaques and the Broca's area in humans show low similarity 24 . Whole-brain morphological comparisons of human and non-human primate brains have shown that the temporal lobe is a major hotspot of expansion and reorganization 34,35 .…”

Section: The Individual Variations Of Sc In Macaques and Humansmentioning

confidence: 94%

“…The similarity of ber shapes in neural ber patterns obtained through DTI is high at the global level, while their differences are greater at the local level in macaques and humans 23 . The SC in areas 44, 45A, and 45 B in macaques, homologs of Broca's area in humans, show individual variability, while human JBA44 and JBA45 also show individual variability 24 . In the present study, we did not compare these brain regions because of the di culty in identifying whether 44, 45A, and 45B in macaques have functions similar to those of Broca's area in humans.…”

Section: The Individual Variations Of Sc In Macaques and Humansmentioning

confidence: 94%

“…1B). In contrast to humans, a few studies have reported inter-individual similarities among macaques in several brain regions 23,24 . The similarity of ber shapes in neural ber patterns obtained through DTI is high at the global level, while their differences are greater at the local level in macaques and humans 23 .…”

Section: The Individual Variations Of Sc In Macaques and Humansmentioning

confidence: 99%

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Multi-scale hierarchical brain regions detect individual and inter-species variations of structural connectivity in macaque monkeys and humans

Tsurugizawa,

Ouchi,

Yoshimaru

et al. 2024

Preprint

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Macaques are representative animal models in translational research. However, the distinct shape and location of the brain regions between macaques and humans prevents us from comparing the brain structure directly. Here, we calculated structural connectivity (SC) with multi-scale hierarchical regions of interest (ROIs) to parcel out human and macaque brain into 4 (level 1 ROIs) or 13 (level 2 ROIs) regions, which consist of anatomically and functionally defined level 3 ROIs (around 100 parcellation of the brain) and similar function. The SC with the level 1 ROIs showed lower individual and inter-species variation in macaques and humans. SC with level 2 ROIs shows that the temporal lobe has high individual and inter-species variation in macaques and humans, while the prefrontal and sensory cortices show low individual and inter-species variation. These results provide insights into the suitability of macaques as animal models for humans.

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Section: The Individual Variations Of Sc In Macaques and Humansmentioning

confidence: 94%

Section: The Individual Variations Of Sc In Macaques and Humansmentioning

confidence: 94%

Section: The Individual Variations Of Sc In Macaques and Humansmentioning

confidence: 99%

See 1 more Smart Citation

Multi-scale hierarchical brain regions detect individual and inter-species variations of structural connectivity in macaque monkeys and humans

Tsurugizawa,

Ouchi,

Yoshimaru

et al. 2024

Preprint

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show abstract

“…Since the Brainnetome Atlases in both humans and macaques have been completed, they offer a potential path for understanding brain evolution by comparative connectivities based on fine-grained brain parcellations across species. Many interesting topics related to evolutionary mechanisms, such as language and tool use, could be explored from the perspective of the Brainnetome Atlases 30,93,94 .…”

Section: A Common and Cross-species Parcellation Pipeline For Comparisonmentioning

confidence: 99%

Macaque Brainnetome Atlas: A Multifaceted Brain Map with Parcellation, Connection, and Histology

Cui

Cao

et al. 2022

Preprint

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The rhesus macaque (Macaca mulatta) is a crucial experimental animal that shares many genetic, brain organizational, and behavioral characteristics with humans. A macaque brain atlas that identifies anatomically and functionally distinct regions is fundamental to biomedical and evolutionary research. However, even though connectivity information is vital for understanding brain functions, a connectivity-based whole-brain atlas of the macaque has not previously been made. In this study, we created a new whole-brain map, the Macaque Brainnetome Atlas, based on the anatomical connectivity profile provided by high-resolution angular and spatial diffusion MRI data. The new atlas consists of 248 cortical and 56 subcortical regions as well as their structural and resting-state functional connections. We systematically evaluated the parcellations and connections using multi-site and multi-modal datasets to ensure reproducibility and reliability. The resulting resource, which is downloadable fromhttp://atlas.brainnetome.org, includes (1) the thoroughly delineated Macaque Brainnetome Atlas (MacBNA), (2) the multi-modal connections, (3) the largest postmortem high resolution macaque dMRI dataset, and (4) ex vivo MRI, block-face, and Nissl-stained images obtained from a different macaque. We provide an exemplar use of the resource with a joint multi-modal and multi-scale utilization of MRI and Nissl data with our atlas as a reference system. The goals of the resource are not only to provide a backbone of the mesoscopic connectivity and a multi-omics (such as transcriptomes and proteomes) atlas but also to facilitate translational medicine, cross-species comparisons, and computational modelling, enriching the collaborative resource platform of nonhuman primate data.

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“…The macaque serves as a natural transitional model for studying humans and has a unique resource advantage. Exploring the working and pathological mechanisms of the human brain through macaques is an important means of brain research (Xia et al, 2021 ). However, the similarity and dissimilarity between the human and macaque brains have become a research hotspot and difficulty.…”

Section: Introductionmentioning

confidence: 99%

Connectivity reveals homology between the visual systems of the human and macaque brains

Wang

et al. 2023

Front. Neurosci.

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The visual systems of humans and nonhuman primates share many similarities in both anatomical and functional organization. Understanding the homology and differences between the two systems can provide important insights into the neural basis of visual perception and cognition. This research aims to investigate the homology between human and macaque visual systems based on connectivity, using diffusion tensor imaging and resting-state functional magnetic resonance imaging to construct structural and functional connectivity fingerprints of the visual systems in humans and macaques, and quantitatively analyze the connectivity patterns. By integrating multimodal magnetic resonance imaging, this research explored the homology and differences between the two systems. The results showed that 9 brain regions in the macaque visual system formed highly homologous mapping relationships with 11 brain regions in the human visual system, and the related brain regions between the two species showed highly structure homologous, with their functional organization being essentially conserved across species. Finally, this research generated a homology information map of the visual system for humans and macaques, providing a new perspective for subsequent cross-species analysis.

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Species and individual differences and connectional asymmetry of Broca's area in humans and macaques

Cited by 10 publications

References 107 publications

Multi-scale hierarchical brain regions detect individual and inter-species variations of structural connectivity in macaque monkeys and humans

Multi-scale hierarchical brain regions detect individual and inter-species variations of structural connectivity in macaque monkeys and humans

Macaque Brainnetome Atlas: A Multifaceted Brain Map with Parcellation, Connection, and Histology

Connectivity reveals homology between the visual systems of the human and macaque brains

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