Species and tissue distribution of gholecystokinin/gastrin-like substances in some invertebrates

Larson, Brett A.; Vigna, Steven R.

doi:10.1016/0016-6480(83)90268-x

Cited by 55 publications

(8 citation statements)

References 15 publications

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“…The present findings confirm our previous demonstration of G/CCK-LI in the A. californica CNS (Larson and Vigna, 1983) and further demonstrate the neuronal origin and some immunochemical properties of this activity.…”

Section: Discussionsupporting

confidence: 92%

“…A factor with immunochemical properties resembling those of gastrin has been described in gut extracts and hemolymph of the marine gastropod mollusc, Aplysia californica (Straus et al, 1975). In a recent survey of gastrin/CCK (G/CCK)-like peptides in invertebrates, we confirmed this finding and added the central nervous system as a source of extractable G/CCK-like immunoreactivity (G/CCK-LI) in Aplysia (Larson and Vigna, 1983). Gastrin/CCK-like peptides have also been reported in the nervous systems of the molluscs Lymnaea stag&is (Schot et al, 1981) and Helix aspersa (Osborne et al, 1982).…”

supporting

confidence: 73%

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Localization and characterization of gastrin/cholecystokinin-like immunoreactivity in the central nervous system of Aplysia californica

Vigna¹,

Morgan²,

Thomas³

1984

J. Neurosci.

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Gastrin/cholecystokinin-like immunoreactivity (G/CCK-LI) was localized by immunocytochemistry in neurons in the central nervous system of Aplysia californica. Neuronal cell bodies were specifically immunostained in the buccal, cerebral, pedal, and abdominal ganglia but not in the pleural ganglia. Neural G/CCK-LI processes were observed in the neuropil of all ganglia and connectives and in some but not all of the peripheral nerves examined. Somata containing G/CCK-LI ranged from 15 to 200 micron in diameter. Ganglionic G/CCK-LI was most efficiently extracted in neutral or basic solutions and consisted mainly of a substance eluting in a volume corresponding to a peptide of between 8 and 17 amino acid residues on gel filtration. This G/CCK-LI diluted in parallel to mammalian gastrin in radioimmunoassays using two antisera differing in their specificities for the bioactive COOH-terminal region of mammalian G/CCK. We conclude that G/CCK-LI is distributed widely in the central and peripheral nervous systems of Aplysia californica and that this immunoreactivity probably represents a small peptide which is similar but not identical to mammalian gastrins and cholecystokinins at the functionally critical COOH terminus.

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Section: Discussionsupporting

confidence: 92%

supporting

confidence: 73%

Localization and characterization of gastrin/cholecystokinin-like immunoreactivity in the central nervous system of Aplysia californica

Vigna¹,

Morgan²,

Thomas³

1984

J. Neurosci.

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“…Evidence that the phylogenetic distribution of CCK/gastrin-type peptides may extend beyond chordates to other phyla was first obtained with the detection of substances immunoreactive with antibodies to CCK and/or gastrin in a variety of invertebrates, including arthropods, annelids, molluscs, and cnidarians ( Dockray et al, 1981 ; El-Salhy et al, 1980 ; Grimmelikhuijzen et al, 1980 ; Kramer et al, 1977 ; Larson and Vigna, 1983 ; Rzasa et al, 1982 ). However, molecular evidence of the evolutionary antiquity of CCK/gastrin-type signalling was obtained with the purification and sequencing of a CCK-like peptide named leucosulfakinin, which was isolated from the insect (cockroach) Leucophaea maderae ( Nachman et al, 1986a ).…”

Section: Introductionmentioning

confidence: 99%

Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

Tinoco

Barreiro‐Iglesias

Yáñez-Guerra

et al. 2021

eLife

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Sulfakinin (SK)/cholecystokinin (CCK)-type neuropeptides regulate feeding and digestion in protostomes (e.g. insects) and chordates. Here, we characterised SK/CCK-type signalling for the first time in a non-chordate deuterostome – the starfish Asterias rubens (phylum Echinodermata). In this species, two neuropeptides (ArSK/CCK1, ArSK/CCK2) derived from the precursor protein ArSK/CCKP act as ligands for an SK/CCK-type receptor (ArSK/CCKR) and these peptides/proteins are expressed in the nervous system, digestive system, tube feet, and body wall. Furthermore, ArSK/CCK1 and ArSK/CCK2 cause dose-dependent contraction of cardiac stomach, tube foot, and apical muscle preparations in vitro, and injection of these neuropeptides in vivo triggers cardiac stomach retraction and inhibition of the onset of feeding in A. rubens. Thus, an evolutionarily ancient role of SK/CCK-type neuropeptides as inhibitory regulators of feeding-related processes in the Bilateria has been conserved in the unusual and unique context of the extra-oral feeding behaviour and pentaradial body plan of an echinoderm.

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Section: Introductionmentioning

confidence: 99%

Evolutionarily ancient role of cholecystokinin-type neuropeptide signalling as an inhibitory regulator of feeding-related processes revealed in an echinoderm

Tinoco

Barreiro‐Iglesias

Yáñez-Guerra

et al. 2020

Preprint

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Cholecystokinin (CCK) / sulfakinin (SK)-type neuropeptides regulate feeding and digestion in chordates and protostomes (e.g. insects). Here we characterised CCK/SK-type signalling for the first time in a non-chordate deuterostome - the starfish Asterias rubens (phylum Echinodermata). In this species, two neuropeptides (ArCCK1, ArCCK2) derived from the precursor protein ArCCKP act as ligands for a CCK/SK-type receptor (ArCCKR) and are expressed in the nervous system, digestive system, tube feet and body wall. Furthermore, ArCCK1 and ArCCK2 cause dose-dependent contraction of cardiac stomach, tube foot and body wall apical muscle preparations in vitro and injection of these neuropeptides in vivo triggers cardiac stomach retraction and inhibition of the onset of feeding in A. rubens. Thus, an evolutionarily ancient role of CCK/SK-type neuropeptides as inhibitory regulators of feeding-related processes in the Bilateria has been conserved in the unusual and unique context of the extra-oral feeding behaviour and pentaradial body plan of an echinoderm.

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Species and tissue distribution of gholecystokinin/gastrin-like substances in some invertebrates

Cited by 55 publications

References 15 publications

Localization and characterization of gastrin/cholecystokinin-like immunoreactivity in the central nervous system of Aplysia californica

Localization and characterization of gastrin/cholecystokinin-like immunoreactivity in the central nervous system of Aplysia californica

Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

Evolutionarily ancient role of cholecystokinin-type neuropeptide signalling as an inhibitory regulator of feeding-related processes revealed in an echinoderm

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