Species Barriers in Prion Disease

Priola, Suzette A.

doi:10.1007/978-3-031-20565-1_13

Cited by 1 publication

(1 citation statement)

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“…A similar pattern is seen in cases of intraspecific transmission of the transmissible spongiform encephalopathies within other mammals-cattle (BSE), sheep (scrapie), etc. Simultaneously, cross-species transmission of infectious prion is difficult (e.g., humans contracting BSE) or impossible (there are no known cases of human infection with the sheep form-scrapie) [17,18]. The reasons why interspecies transmission occurs in some cases and not in others are unknown, but there is a possibility that it is determined by the composition of the microbiota, which could define the efficiency of transport from the gastrointestinal tract to nervous tissues and, therefore, the probability level of PrP pathologic transformation.…”

Section: The Role Of Chaperones In the Pathological Transformation Of...mentioning

confidence: 99%

Are Gastrointestinal Microorganisms Involved in the Onset and Development of Amyloid Neurodegenerative Diseases?

Muronetz,

Kurochkina,

Leisi

et al. 2023

Microbiology Research

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This review discusses a few examples of specific mechanisms mediating the contribution of the GIT microbiota to the development of amyloid neurodegenerative diseases caused by the pathologic transformation of prion protein, or alpha-synuclein. The effect of the bacterial GroE chaperonin system and phage chaperonins (single-ring OBP and double-ring EL) on prion protein transformation has been described. A number of studies have shown that chaperonins stimulate the formation of cytotoxic amyloid forms of prion protein in an ATP-dependent manner. Moreover, it was found that E. coli cell lysates have a similar effect on prion protein, and the efficiency of amyloid transformation correlates with the content of GroE in cells. Data on the influence of some metabolites synthesized by gut microorganisms on the onset of synucleinopathies, such as Parkinson’s disease, is provided. In particular, the induction of amyloid transformation of alpha-synuclein from intestinal epithelial cells with subsequent prion-like formation of its pathologic forms in nervous tissues featuring microbiota metabolites is described. Possible mechanisms of microbiota influence on the occurrence and development of amyloid neurodegenerative diseases are considered.

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Section: The Role Of Chaperones In the Pathological Transformation Of...mentioning

confidence: 99%