2020
DOI: 10.1101/2020.09.01.278846
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Species-Dependent Heterophilic and Homophilic Cadherin Interactions in Intestinal Intermicrovillar Links

Abstract: Enterocytes are specialized epithelial cells lining the luminal surface of the small intestine that build densely packed arrays of microvilli known as brush borders. These microvilli drive nutrient absorption and are arranged in a hexagonal pattern maintained by intermicrovillar links formed by two non-classical members of the cadherin superfamily of calcium-dependent cell adhesion proteins: protocadherin-24 (PCDH24, also known as CDHR2) and the mucin-like protocadherin (CDHR5). The extracellular domains of th… Show more

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