Species difference in carotid body response of cat and dog to dopamine and serotonin

Am, Black; Jh, Comroe; Jacobs, Laurie

doi:10.1152/ajplegacy.1972.223.5.1097

Cited by 80 publications

(43 citation statements)

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“…MATSUMOTO et al (1980a) already ascertained that in the rabbit, DA in a low dose had a potent chemoreceptor depressing effect leading to marked decreases in respiratory rate and VT and these effects were not evoked after the section of the CNS. There is other evidence that in the cat, an intracarotid injection of DA led to an immediate inhibition of ventilation through a carotid chemoreflex because it produced no response when the CSN was sectioned (BLACK et al, 1972). Therefore, it may be more conceivable that DA exerts its inhibitory effect on respiratory muscle activity through a carotid chemoreflex.…”

Section: Discussionmentioning

confidence: 99%

Effects of carotid chemoreceptor stimulating and depressing agents on internal intercostal muscle activity in the rabbit.

Matsumoto

1986

Jpn.J.Physiol

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The effects of carotid chemoreceptor stimulating and depressing agents on internal intercostal muscle activity (IIMA) were studied before and after surgical denervation of the carotid sinus nerve (CSN) in the rabbit. An intracarotid injection of 30 µg of sodium cyanide (NaCN) during inspiration caused an increase in both IIMA and respiratory rate (RR). In contrast, intracarotid administration of 10 µg of dopamine (DA) during inspiration resulted in a decrease in both IIMA and RR. The NaCN-and DA-induced characteristic responses in IIMA were abolished by the section of the CSN. The results indicate that the excitatory and inhibitory responses of IIMA to intracarotid injections of NaCN and DA are mainly mediated through carotid chemoreflexes.

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Section: Discussionmentioning

confidence: 99%

Effects of carotid chemoreceptor stimulating and depressing agents on internal intercostal muscle activity in the rabbit.

Matsumoto

1986

Jpn.J.Physiol

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“…It has been shown that noradrenaline in the dog causes an increase in chemoreceptor discharge (Joels & White, 1968;Black et al, 1972). When CO2 and noradrenaline were given simultaneously to the donor dog a greater vasodilation in the recipient cerebral circulation occurred.…”

Section: Discussionmentioning

confidence: 99%

“…In the dog noradrenaline has been shown to cause an increase in the afferent discharge from the carotid body chemoreceptors (Black, Comroe & Jacobs, 1972). Some of the changes observed in the cerebral circulation following noradrenaline administration could, therefore, not only be due to a direct effect on the vessel wall, or secondary to blood pressure changes but could possibly be caused by activation of the carotid body chemoreceptors. Some years ago we demonstrated that hypercapnia attenuated the vasodilator response of the cerebral circulation to an isoprenaline infusion (Xanalatos & James, 1972).…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting the Cerebrovascular Response to Noradrenaline in the Dog

James

MacDonell

1975

British J Pharmacology

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1Noradrenaline infused into the internal carotid artery of the dog (0.01-1 Mg kg-' min-)constricts the blood vessels of the cortex. This constriction is mediated by the action of noradrenaline on a-adrenoceptors of the cerebral arteries.2 Intravenous (1 ,g kg-' min-) or intra common carotid arterial (0.01-1 Mg kg-' min-) infusions of noradrenaline cause an increase in cortical blood flow that can be dissociated from changes in blood pressure. 3 The effect of intravenous noradrenaline on the cortical blood vessels and metabolism is blocked by high Paco2 levels, or by the prior administration of (+)-propranolol. (+)-Propranolol is without such effect. 4 Following section of both vagi and both sinus nerves, intravenous noradrenaline fails to cause an increase in cortical blood flow. 5 In another series of animals the area of the carotid bifurcation was vascularly isolated and perfused with blood from a second dog. Chemoreceptor and baroreceptor activity was shown to be intact. 6 Administration of 5% CO2 to the donor dog caused an increase in cerebral blood flow in the recipient dog. 9 This evidence suggests that the cerebrovasodilatation observed following intravenous noradrenaline is reflex and is triggered by chemoreceptor activity. 10 The evidence also suggests that the antagonism of the cortical dilatory effects of intravenous noradrenaline by raised Paco2 in the intact animal must be at a site different from the peripheral chemoreceptors.

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“…~ere is also convincing evidence that these substances are contained primarily within the glomus, or Type I, cells of the carotid body [6,7]. Electrophysiological and pharmacological studies in the cat [23,24,28], dog [4] and rabbit (Monti-Bloch and Eyzaguirre, pets. comm.)…”

mentioning

confidence: 99%

“…However, the precise mode of action of DA in carotid body chemoreception remains to be elucidated, and there is now evidence that the effe~ ; of exogenous DA on the chemosensory discharges of the carotid nerve may be species dependent. Thus, in the cat, DA inhibits the chemosensory discharges [23,24,28], but appears to be stimul~tory in the dog [4] and rabbit (Monti-Bloch and Eyzaguirre, pers. comm.).…”

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confidence: 99%

Increased release of [3H]dopamine during low O2 stimulation of rabbit carotid body in vitro

González

Fidone

1977

Neuroscience Letters

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SUMMARYRabbit carotid bodies synthesized [3H]dopamine (DA) during a 3-h incubation period in modified Tyrode's solution containing 40 uM [3H]tyrosine. Following tbis loading period, the carotid bodies were exposed for one additional hour to unlabelled Tyrode's solution equilibrated with either 10% oxygen in nitrogen or with 100% oxygen. The carotid bodies exposed to low O2 released 81% more [3H]dopamine during this one-hour period than the carotid bodies exposed only to pure oxygen. These data suggest that hypoxia induces release of DA from the carotid body.It is now well documented that the mammalian carotid body contains the biogenic amines dopamine, norepinephrine and 5-hydroxytryptamine [9,12,29], and that of these, dopamine (DA) is present in the tissue in the highest concentration [12,15]. ~ere is also convincing evidence that these substances are contained primarily within the glomus, or Type I, cells of the carotid body [6,7]. Electrophysiological and pharmacological studies in the cat [23,24,28], dog [4] and rabbit (Monti-Bloch and Eyzaguirre, pets. comm.) have shown that exogenous DA alters chemoreceptor activity recorded from the carotid nerve, and it has been suggested that during natural stimulation of the carotid body release of endogenous DA from the glomus cells may function to modulate the activity of chemoreceptor nerve fibers which terminate upon these cells [2,14,28]. However, previous studies of the effects of natural stimulation on the DA stores of the carotid body have produced conflicting results, and there are no ~tudies which have attempted to directly demonstrate either increased release or tunlover of carotid body DA during natttral stimu]a-

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Species difference in carotid body response of cat and dog to dopamine and serotonin

Cited by 80 publications

References 0 publications

Effects of carotid chemoreceptor stimulating and depressing agents on internal intercostal muscle activity in the rabbit.

Effects of carotid chemoreceptor stimulating and depressing agents on internal intercostal muscle activity in the rabbit.

Factors Affecting the Cerebrovascular Response to Noradrenaline in the Dog

Increased release of [3H]dopamine during low O2 stimulation of rabbit carotid body in vitro

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