Species distribution and drug susceptibility of candida in clinical isolates from a tertiary care centre at Indore

Pahwa, Naresh; Kumar, Ravindra; Nirkhiwale, S.; Bandi, Ashwini

doi:10.4103/0255-0857.124300

Cited by 52 publications

(39 citation statements)

References 18 publications

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“…Result of our study has shown that a maximum number of the isolates were from male patients and elder population were mostly effected which is with the agreement of the study done by Pahwa et al [4] We are not the first to report that diabetics were one of the most common predisposing factors for candidiasis other investigator also reported the same [11]. These findings indicate that due to the poor immune response by elderly patients and predisposing factor such as diabetes mellitus may act as an important risk factor for candidiasis.…”

Section: Discussionsupporting

confidence: 92%

“…Several other investigator form India also reported a high prevalence of Candida causing UTI [4]. However, the incidence of invasive isolates was less in our study isolates in compare to other studies where they had found a high prevalence of invasive isolates in their study population [9,10].…”

Section: Discussioncontrasting

confidence: 70%

“…The most common predisposing factor was diabetics [37(35.5%)] followed by AIDS [4] (4%)] respectively.…”

Section: Resultsmentioning

confidence: 99%

“…In India, there is insufficient data regarding the Candida species and their susceptibility pattern [4] hence, the present study was undertaken to identify different Candida species and their sensitivity pattern with the available antifungal agents.…”

Section: Introductionmentioning

confidence: 99%

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Antifungal Drug Resistance among Candida albicans and Non-albicans Candida Species Isolates from a Tertiary Care Centre at Allahabad

Singh¹,

Chakraborty²

2017

J Antimicrob Agents

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Objective: The aim of our study was to identify the distribution of Candida species among clinical isolates and their sensitivity pattern for common antifungal drugs.Methods: This descriptive study was carried out in a tertiary care hospital in Allahabad. A total of One hundred and four Candida isolates were included in the study. Identification and speciation of the isolates were carried out by Germ-tube test, Chlamydoconidia production test, colony characterization in chromogenic agar medium, carbohydrate assimilation test and growth at 45°C. Four antifungal drugs such as Fluconazole (25 mcg), Clotrimazole (10 mcg), Nystatin (100 U) and Amphotericin-B (100 U) were tested by disk diffusion method. Descriptive statistics was used which involves the use of simple percentage and bar chart to analyze the data. In addition, Chi-square test was performed and P value was calculated.Results: Out of 104 Candida isolates, 60 (58%) were from Urine, 36 (34.5%) were from Sputum and 8(7.5%) were from blood isolates. Of the total of 104 isolates 64 (61.5%) were Candida albicans, 20(19%) Candida dubliniensis, 10 (9%) Candida tropicalis, 7(6.5%) Candida parapsilosis and 4(4%) Candida glabrata respectively. Resistance rates for commonly use antifungal drugs among the isolates are as followed Fluconazole 76 (73%), Amphotericin B 40 (38.5%), Nystatin 4(4%) and Clotrimazole 60 (58%) respectively. For Candida albicans and Candida dubliniensis most active antifungal drug was Nystatin (93%; 100% respectively).Discussion: Species level identification of Candida and their antifungal sensitivity testing should be performed routinely in all microbiology laboratories to prevent the spread of antifungal resistance.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 70%

“…The most common predisposing factor was diabetics [37(35.5%)] followed by AIDS [4] (4%)] respectively.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antifungal Drug Resistance among Candida albicans and Non-albicans Candida Species Isolates from a Tertiary Care Centre at Allahabad

Singh¹,

Chakraborty²

2017

J Antimicrob Agents

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“…The samples were taken from the oral cavity of the elderly, and this percentage shows a high resistance. In a study in patients admitted to the intensive care unit, non -albicans strains showed a high resistance to azoles (15).…”

Section: Discussionmentioning

confidence: 99%

The Inhibitory Effect of Probiotic Bacteria against Drug - Resistant Candida Species Isolated from the Oral Cavity of the Elderly

Biyari

Fozouni

2018

Shiraz E-Med J

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Background: Candidiasis includes a range of opportunistic fungal diseases that appear in various forms such as oral thrush and stomatitis in the elderly. Recently, the resistance of Candida species to antibiotics selected to treat oral infections has increased significantly. Objectives: This study aimed to determine the antagonistic effects of probiotics on oral candidiasis in the elderly. Patients and Methods: Swab samples from the saliva and mouth of 72 elders residing in the elderly care centers in Gorgan were cultured in Sabouraud dextrose agar (SDA). The Candida spp. and Candida albicans were identified by culturing in CHROMagar Candida medium and using a PCR identification kit and API 20CAUX system. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of nystatin and itraconazole based on the CLSI document. The well -diffusion method and the modified agar method were applied to separate dairy -isolated probiotics from cultures in MRS and M17 media and to study their antimicrobial effect. Results: Overall, 47 Candia isolates in seven different species were diagnosed. The MICs of itraconazole and nystatin were within

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Molecular epidemiology of Candida tropicalis isolated from urogenital tract infections

Wang

Tang

et al. 2020

MicrobiologyOpen

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Candida spp. are important components of the microflora of human skin, oral and vaginal mucosa, and gastrointestinal tract. They are important opportunistic pathogens that can cause superficial and invasive infections in human hosts (Falagas et al., 2010). Over the past decade, infections caused by Candida have risen significantly and become an important cause of nosocomial infections, leading to serious public health problems (Gajdács

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Species distribution and drug susceptibility of candida in clinical isolates from a tertiary care centre at Indore

Abstract: Species-level identification of Candidaand their antifungal sensitivity testing should be performed to achieve better clinical results.

Cited by 52 publications

References 18 publications

Antifungal Drug Resistance among Candida albicans and Non-albicans Candida Species Isolates from a Tertiary Care Centre at Allahabad

Antifungal Drug Resistance among Candida albicans and Non-albicans Candida Species Isolates from a Tertiary Care Centre at Allahabad

The Inhibitory Effect of Probiotic Bacteria against Drug - Resistant Candida Species Isolated from the Oral Cavity of the Elderly

Molecular epidemiology of Candida tropicalis isolated from urogenital tract infections

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