Species diversity of yeast in oral colonization of insulin-treated diabetes mellitus patients

Pires, Regina Helena; Miranda, Elaine Toscano; Zaia, José Eduardo; Mendes-Giannini, María José Soares

doi:10.1007/s11046-006-0038-5

Cited by 40 publications

(39 citation statements)

References 38 publications

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“…In two chronic cases with type 2 diabetes mellitus, superficial cutaneous trichosporonosis was also present, i.e., a superficial infection with development of erythematous, scaly plaques, similar to superficial candidiasis with pruritus, and in both cases the same etiologic agent ( T. inkin ), was isolated. This manifestation is likely to be favored by diabetes, which has been reported from mucocutaneous to systemic infections [4, 24]. …”

Section: Discussionmentioning

confidence: 99%

White Piedra: Clinical, Mycological, and Therapeutic Experience of Fourteen Cases

Bonifáz¹,

Tirado‐Sánchez²,

Santibáñez³

et al. 2018

Skin Appendage Disord

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Background: White piedra (WP) is an asymptomatic superficial mycosis that affects the hair stems, forming whitish nodules caused by various species of the genus Trichosporon. Objective: To present a case series of WP of the head, its epidemiological data, as well as clinical, mycological, and therapeutic experience. Methods: We conducted a 12-year retrospective and observational study of WP cases tested by dermoscopy, mycological study, and the identification of species through morphology, biochemistry, and proteomics (matrix-assisted laser desorption/ionization time-of-flight mass spectrometry). The treatment was based on ketoconazole shampoo as well as keratolytics. Results: We included 14 cases of WP, all located in the head and 1 case with both head and scrotum affected. Nine cases (64.3%) presented in children aged < 15 years. The majority of the cases (13/14, 92.8%) were women. Two cases were associated with hyperkeratosis and intertrigo. Most patients had long hair and excessive moisture. In all cases hair nodules were observed and Trichosporon inkin (11/14, 78.6%) was usually isolated. Eleven cases (78.6%) were cured by administering 2% ketoconazole shampoo. Conclusion: WP was observed in school-age girls. The diagnosis was based on the observation of hair nodules and its main etiologic agent was T. inkin, with good response to treatment in most cases.

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Section: Discussionmentioning

confidence: 99%

White Piedra: Clinical, Mycological, and Therapeutic Experience of Fourteen Cases

Bonifáz¹,

Tirado‐Sánchez²,

Santibáñez³

et al. 2018

Skin Appendage Disord

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“…isolates have been obtained from various parts of the body (3-6), and those from the oral flora account for as much as 30% of healthy individuals (26,27); compared with this figure, our isolation rates were lower (2.8% and 6.33%). A recent study by Goncalves et al (24) of colonization in diabetic patients (treated with insulin) found that Geotrichum spp. was isolated at a rate of 0.57%.…”

Section: Discussionmentioning

confidence: 99%

“…It is important to emphasize that the majority of cases were associated with diabetes mellitus, and this is probably due to the presence of higher serum glucose levels, which stimulate the growth of yeasts such as Candida, Geotrichum and Trichosporon. Recognition of this fact allows the use of prophylactic treatment, as is also the case for affected patients who are immunosuppressed (4,23,24).…”

Section: Discussionmentioning

confidence: 99%

Oral geotrichosis: report of 12 cases

et al. 2010

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Oral geotrichosis is an uncommonopportunistic infection caused by Geotrichum candidum, a habitual contaminant and component of the flora of various parts of the body. This communication reports both a 20-year retrospective study of clinically and mycologically proven cases of oral geotrichosis, and a prospective study of fungal oral flora in 200 individuals divided into two groups: normal individuals and individuals with associated conditions. Twelve patients with proven oral geotrichosis were included: 9 females and 3 males, with a mean age of 48.5 years; the associated conditions were diabetes mellitus (66.6%), leukemia, Hodgkin's lymphoma and HIV/AIDS infection. The oral geotrichoses showed three clinical varieties: pseudomembranous (75%), hyperplastic, and palatine ulcer. G. candidum was isolated in 11 cases and G. capitatum in one. Positive fungal cultures were obtained from the two groups, and 48% and 78% of cultures were positive, respectively, for Candida spp. In 2.8% and 6.33% of the cases, G. candidum was isolated, respectively, together with one strain of G. capitatum. Oral geotrichosis is an exceptional infection that clinically presents, and is treated, as oral candidiasis. G. candidum may be isolated from the oral flora of a small proportion of patients, either normal individuals or those with associated conditions. (J Oral Sci 52, 477-483, 2010)

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“…C. parapsilosis is of special concern in critically ill neonates leading to high morbidity and mortality [6]. Furthermore, C. parapsilosis has been isolated from the oral cavity of of HIV-infected [7] and diabetic individuals [8]. Although these studies document C. parapsilosis pathogenicity, further investigations are warranted to determine how human tissues can interact with, and prevent C. parapsilosis infection.…”

Section: Introductionmentioning

confidence: 99%

Normal Human Gingival Epithelial Cells SenseC. parapsilosisby Toll-Like Receptors and Module Its Pathogenesis through Antimicrobial Peptides and Proinflammatory Cytokines

Bahri

Curt

Saidane-Mosbahi

et al. 2010

Mediators of Inflammation

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This study was designed to investigate the interaction between C. parapsilosis and human epithelial cells using monolayer cultures and an engineered human oral mucosa (EHOM). C. parapsilosis was able to adhere to gingival epithelial cells and to adopt the hyphal form in the presence of serum. Interestingly, when cultured onto the engineered human oral mucosa (EHOM), C. parapsilosis formed small biofilm and invaded the connective tissue. Following contact with C. parapsilosis, normal human gingival epithelial cells expressed high levels of Toll-like receptors (TLR)-2, -4, and -6, but not TLR-9 mRNA. The upregulation of TLRs was paralleled by an increase of IL-1β, TNFα, and IFNγ mRNA expression, suggesting the involvement of these cytokines in the defense against infection with C. parapsilosis. The active role of epithelial cells in the innate immunity against C. parapsilosis infection was enhanced by their capacity to express high levels of human beta-defensin-1, -2, and -3. The upregulation of proinflammatory cytokines and antimicrobial peptide expression may explain the growth inhibition of C. parapsilosis by the gingival epithelial cells. Overall results provide additional evidence of the involvement of epithelial cells in the innate immunity against C. parapsilosis infections.

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Species diversity of yeast in oral colonization of insulin-treated diabetes mellitus patients

Cited by 40 publications

References 38 publications

White Piedra: Clinical, Mycological, and Therapeutic Experience of Fourteen Cases

White Piedra: Clinical, Mycological, and Therapeutic Experience of Fourteen Cases

Oral geotrichosis: report of 12 cases

Normal Human Gingival Epithelial Cells SenseC. parapsilosisby Toll-Like Receptors and Module Its Pathogenesis through Antimicrobial Peptides and Proinflammatory Cytokines

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