Species-Related Differences in the Mechanism of Apoptosis During Structural Luteolysis

Sugino, Norihiro; Okuda, Kiyoshi

doi:10.1262/jrd.19047

Cited by 75 publications

(90 citation statements)

References 71 publications

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“…Luteolysis is defined as the loss of function and subsequent involution of the luteal structure. The luteolytic process is usually subdivided, whereby the decline in progesterone is described as functional luteolysis and the structural involution is described as structural luteolysis (Sugino and Okuda, 2007). Apoptosis plays a key role in the demise of the majority of mammalian gonadal cells (follicular granulosa and luteal cells in ovaries and germ cells in the testes) during the reproductive cycle.…”

Section: Discussionmentioning

confidence: 99%

Expression and localization of cFLIP anti-apoptotic protein in the porcine corpus luteum and corpora albicans during the estrous cycle and pregnancy

Hz¹,

Ws²,

Tian³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We determined expression and localization of the antiapoptotic cellular FLICE inhibitory protein (cFLIP) in the porcine corpora lutea (CL) and corpus albicans (CA) during estrous and pregnancy. The CL and CA were collected at different stages of estrous to determine cFLIP immunolocalization, and mRNA and protein expression. The mRNA expression of the short cFLIP isoform (cFLIP S ) was higher at the early and mid CL stages, and lower by the late CL stage (P < 0.01); mRNA expression of the long cFLIP isoform (cFLIP L ) was higher at the mid CL stage, and lower at the early and late CL stages (P < 0.01). Levels of cFLIP S and cFLIP L were steady and high during the early and mid CL stages, and had significantly decreased (P < 0.01) by the late stage. The cFLIP protein was highly expressed in the early and mid CL stages of estrous, but weakly expressed in the late stage. Expression of cFLIP S showed no significant difference between preovulatory corpus albicans (CA1) and corpus (2015) albicans (CA2) coexistent with the CL from the previous estrus, but cFLIP L mRNA expression was higher during CA1 than CA2. The expression of cFLIP S showed no significant difference between CA1 and CA2, but cFLIP L was not detected. The cFLIP protein was weakly expressed in the CA. Expression of cFLIP S and cFLIP L mRNA and proteins was observed in the CL, and the cFLIP protein was highly expressed during pregnancy. We propose that cFLIP S/L acts as a survival factor, and performs an anti-apoptotic function in the porcine CL.

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Section: Discussionmentioning

confidence: 99%

Expression and localization of cFLIP anti-apoptotic protein in the porcine corpus luteum and corpora albicans during the estrous cycle and pregnancy

Hz¹,

Ws²,

Tian³

et al. 2015

Genet. Mol. Res.

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“…Inter-species differences in the factors that induce luteal cell apoptosis and the low number of apoptotic cells observed in situ at any given time has made clarification of the precise mechanisms involved challenging (reviewed in Sugino & Okuda (2007)). In an attempt to overcome this latter problem, Goyeneche et al (2006) used an in vitro model of rat luteal cell apoptosis to investigate the cellular machinery involved.…”

Section: Bh3 Interacting Domain Death Agonistmentioning

confidence: 99%

The role of BH3-only proteins in apoptosis within the ovary

Hutt¹

2015

Reproduction

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BH3-only proteins are pro-apoptotic members of the BCL2 family that play pivotal roles in embryonic development, tissue homeostasis and immunity by triggering cell death through the intrinsic apoptosis pathway. Recent in vitro and in vivo studies have demonstrated that BH3-only proteins are also essential mediators of apoptosis within the ovary and are responsible for the initiation of the cell death signalling cascade in a cell type and stimulus-specific fashion. This review gives a brief overview of the intrinsic apoptosis pathway and summarise the roles of individual BH3-only proteins in the promotion of apoptosis in embryonic germ cells, oocytes, follicular granulosa cells and luteal cells. The role of these proteins in activating apoptosis in response to developmental cues and cell stressors, such as exposure to chemotherapy, radiation and environmental toxicants, is described. Studies on the function of BH3-only proteins in the ovary are providing valuable insights into the regulation of oocyte number and quality, as well as ovarian endocrine function, which collectively influence the female reproductive lifespan and health.Reproduction (2015) 149 R81-R89

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“…Previous studies have demonstrated that PRL shows specific roles in ovarian function, such as its luteotropic effect on newly formed corpora lutea [6] and luteolytic effect on aged corpora lutea in rats [30]. A PRL surge occurs during the periovulatory period [1,29,31,32] and induces apoptosis of lutein cells and structural luteolysis when the corpus luteum ceases progesterone production in rats [4,6,8,15,30].…”

mentioning

confidence: 99%

Prolactin Secretion and Ovarian Function in Cycling and Non-Cycling African Female Elephants (Loxodonta africana)

Yamamoto

Watanabe

et al. 2010

J. Vet. Med. Sci.

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ABSTRACT. Reproduction of captive elephants in zoos has shown a low fecundity and requires improvement. One of the reasons for low fecundity is ovarian dysfunction in many female elephants. To investigate whether prolactin has a correlation with ovarian function in female elephants, the serum concentrations of prolactin, progesterone and estradiol-17 in four African female elephants (one cycling female and three non-cycling female elephants) were measured. Cyclic patterns of prolactin and estradiol-17 were observed in the cycling female elephant, which tended to be high during the follicular phase and low during the luteal phase. On the other hand, a cyclic pattern of prolactin was not observed in the non-cycling female elephants. One of the three non-cycling females (Mako) had developed breasts and showed significantly higher average levels of prolactin than the other female elephants. These results suggested that high concentrations of circulating estradiol-17 during the follicular phase stimulated prolactin secretion. They also suggested that hyperprolactinemia in Mako was one of the causes of the developed mammary glands and ovarian dysfunction.

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Species-Related Differences in the Mechanism of Apoptosis During Structural Luteolysis

Cited by 75 publications

References 71 publications

Expression and localization of cFLIP anti-apoptotic protein in the porcine corpus luteum and corpora albicans during the estrous cycle and pregnancy

Expression and localization of cFLIP anti-apoptotic protein in the porcine corpus luteum and corpora albicans during the estrous cycle and pregnancy

The role of BH3-only proteins in apoptosis within the ovary

Prolactin Secretion and Ovarian Function in Cycling and Non-Cycling African Female Elephants (Loxodonta africana)

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