Species-specific expression of parvalbumin in the entorhinal cortex of the Mongolian gerbil: dependence on local activity but not extrinsic afferents

Bender, Roland A.; Hoffmann, Marie-Charlotte; Frotscher, Michael; Nitsch, Cordula

doi:10.1016/s0306-4522(00)00208-6

Cited by 16 publications

(11 citation statements)

References 52 publications

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“…The strong loss of PV immunoreactivity signals a reduced activity state of the affected neurons (Bender et al, 2000;Lewis et al, 2005;Tropea et al, 2006;Schwaller, 2009;Sun, 2009). Reduced neuronal activity is likely resulting from a depression of the excitatory inputs.…”

Section: Discussionmentioning

confidence: 99%

“…1; supplemental material, available at www.jneurosci.org, for further details). CaBPs were found to be expressed in an activity-dependent manner (Bender et al, 2000;Lewis et al, 2005;Tropea et al, 2006;Schwaller, 2009;Sun, 2009). Moreover, expression of distinct CaBPs correlates with the temporal characteristics of neuronal spiking activity (e.g., fast-spiking vs non-fast-spiking) and controls short-term plasticity of inhibitory synapses via the temporal dynamics of presynaptic calcium buffering and transmitter release (Caillard et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Theta-Burst Transcranial Magnetic Stimulation Alters Cortical Inhibition

Benali¹,

Trippe²,

Weiler³

et al. 2011

J. Neurosci.

181

190

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Human cortical excitability can be modified by repetitive transcranial magnetic stimulation (rTMS), but the cellular mechanisms are largely unknown. Here, we show that the pattern of delivery of theta-burst stimulation (TBS) (continuous versus intermittent) differently modifies electric activity and protein expression in the rat neocortex. Intermittent TBS (iTBS), but not continuous TBS (cTBS), enhanced spontaneous neuronal firing and EEG gamma band power. Sensory evoked cortical inhibition increased only after iTBS, although both TBS protocols increased the first sensory response arising from the resting cortical state. Changes in the cortical expression of the calcium-binding proteins parvalbumin (PV) and calbindin D-28k (CB) indicate that changes in spontaneous and evoked cortical activity following rTMS are in part related to altered activity of inhibitory systems. By reducing PV expression in the fast-spiking interneurons, iTBS primarily affected the inhibitory control of pyramidal cell output activity, while cTBS, by reducing CB expression, more likely affected the dendritic integration of synaptic inputs controlled by other classes of inhibitory interneurons. Calretinin, the third major calcium-binding protein expressed by another class of interneurons was not affected at all. We conclude that different patterns of TBS modulate the activity of inhibitory cell classes differently, probably depending on the synaptic connectivity and the preferred discharge pattern of these inhibitory neurons.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Theta-Burst Transcranial Magnetic Stimulation Alters Cortical Inhibition

Benali¹,

Trippe²,

Weiler³

et al. 2011

J. Neurosci.

181

190

View full text Add to dashboard Cite

show abstract

“…, 2003), mostly in addition to PV. Both proteins have been shown to be expressed in an activity‐dependent manner (Bender et al. , 2000; Patz et al.…”

Section: Discussionmentioning

confidence: 99%

Continuous and intermittent transcranial magnetic theta burst stimulation modify tactile learning performance and cortical protein expression in the rat differently

Mix

Benali

Eysel

et al. 2010

Eur J of Neuroscience

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Repetitive transcranial magnetic stimulation (rTMS) can modulate cortical excitability in a stimulus-frequency-dependent manner. Two kinds of theta burst stimulation (TBS) [intermittent TBS (iTBS) and continuous TBS (cTBS)] modulate human cortical excitability differently, with iTBS increasing it and cTBS decreasing it. In rats, we recently showed that this is accompanied by changes in the cortical expression of proteins related to the activity of inhibitory neurons. Expression levels of the calcium-binding protein parvalbumin (PV) and of the 67-kDa isoform of glutamic acid decarboxylase (GAD67) were strongly reduced following iTBS, but not cTBS, whereas both increased expression of the 65-kDa isoform of glutamic acid decarboxylase. In the present study, to investigate possible functional consequences, we applied iTBS and cTBS to rats learning a tactile discrimination task. Conscious rats received either verum or sham rTMS prior to the task. Finally, to investigate how rTMS and learning effects interact, protein expression was determined for cortical areas directly involved in the task and for those either not, or indirectly, involved. We found that iTBS, but not cTBS, improved learning and strongly reduced cortical PV and GAD67 expression. However, the combination of learning and iTBS prevented this effect in those cortical areas involved in the task, but not in unrelated areas. We conclude that the improved learning found following iTBS is a result of the interaction of two effects, possibly in a homeostatic manner: a general weakening of inhibition mediated by the fast-spiking interneurons, and re-established activity in those neurons specifically involved in the learning task, leading to enhanced contrast between learning-induced and background activity.

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“…Digoxigenin (DIG)-labeled antisense and sense probes were generated from a pBluescript transcription vector containing rat GAD67 cDNA (Erlander et al, 1991) and from mouse reelin cDNA that was synthesized using PCR (Haas et al, 2000). GAD67-and reelin-ISH was performed as described previously (Bender et al, 2000;Haas et al, 2000). Briefly, sections were washed with 2ϫ SSC (0.3 M NaC l and 0.03 M Na-citrate) for 30 min and then subjected to an additional 30 min incubation in a solution composed of 2ϫ SSC -prehybridization solution (1:1).…”

Section: Methodsmentioning

confidence: 99%

Novel and Transient Populations of Corticotropin-Releasing Hormone-Expressing Neurons in Developing Hippocampus Suggest Unique Functional Roles: A Quantitative Spatiotemporal Analysis

et al. 2001

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Robust physiological actions of the neuropeptide corticotropinreleasing hormone (CRH) on hippocampal pyramidal neurons have been demonstrated, which may contribute to synaptic efficacy and to learning and memory processes. These excitatory actions of the peptide, as well as the expression of the CRH receptor type that mediates them, are particularly prominent during early postnatal life, suggesting that endogenous CRH may contribute to processes involved in maturation of hippocampal circuitry. To further elucidate the function(s) of endogenous CRH in developing hippocampus, we used neurochemical and quantitative stereological methods to characterize in detail CRH-expressing neuronal populations during postnatal hippocampal differentiation. These experiments revealed progressively increasing numbers of CRH-expressing neurons in developing hippocampus that peaked on postnatal day 11-18 and then declined drastically to adult levels. These cells belonged to several discrete populations, distinguished by GAD67 mRNA expression, morphology, and distinct spatiotemporal distribution profiles. Importantly, a novel population of Cajal-Retzius-like CRH-expressing neurons was characterized that exists only transiently in early postnatal hippocampus and is positioned to contribute to the establishment of hippocampal connectivity. These findings suggest novel, age-specific roles for CRH in regulating early developmental events in the hippocampal formation.

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Species-specific expression of parvalbumin in the entorhinal cortex of the Mongolian gerbil: dependence on local activity but not extrinsic afferents

Cited by 16 publications

References 52 publications

Theta-Burst Transcranial Magnetic Stimulation Alters Cortical Inhibition

Theta-Burst Transcranial Magnetic Stimulation Alters Cortical Inhibition

Continuous and intermittent transcranial magnetic theta burst stimulation modify tactile learning performance and cortical protein expression in the rat differently

Novel and Transient Populations of Corticotropin-Releasing Hormone-Expressing Neurons in Developing Hippocampus Suggest Unique Functional Roles: A Quantitative Spatiotemporal Analysis

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