Species-wide distribution of highly polymorphic minisatellite markers suggests past and present genetic exchanges among house mouse subspecies

Bonhomme, François; Rivals, Éric; Orth, Annie; Grant, Gemma R.; Jeffreys, Alec J.; Bois, Philippe R.J.

doi:10.1186/gb-2007-8-5-r80

Cited by 47 publications

(57 citation statements)

References 30 publications

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“…From its native Eurasian distribution, the house mouse subsequently expanded its range worldwide through passive transport with humans. The evolutionary history of the subspecific radiation of M. musculus has been extensively documented and most of the molecular analyses concur with the paleontological data in identifying the Indian subcontinent as the cradle from which the species expanded (Bonhomme et al, 2007;Geraldes et al, 2008;Duvaux et al, in press). This region is currently occupied by M. m. castaneus and represents the ancestral range of the species.…”

Section: Introductionmentioning

confidence: 66%

“…This extensive NOR diversity indicated that high rates of inter-chromosomal transposition existed within the Mus genome in the absence of cytogenetically visible rearrangements. The house mouse is an Eurasian polytypic species with five currently recognized subspecies: M. m. domesticus, the Western European house mouse, occupies western Europe and the Mediterranean Basin to southwestern Iran; M. m. musculus, the eastern European house mouse, extends in fact from northern Europe to China; M. m. castaneus, the Asian house mouse, is present from central to southeast Asia (Bonhomme et al, 2007;Geraldes et al, 2008;Rajabi-Maham et al, 2008); M. m. molossinus, the Japanese house mouse, is restricted to Japan and neighboring countries and originated by hybridization between M. m. musculus and M. m. castaneus (Yonekawa et al, 2012); finally M. m. gentilulus, the Arabian house mouse, is the most recently rehabilitated subspecies occupying the southern Arabian peninsula (Prager et al, 1998;Duplantier et al, 2002). Two extant hybrid zones exist involving M. m. musculus, one with M. m. domesticus in Europe and the other with M. m. castaneus in China (Bonhomme et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Chromosomal dynamics of nucleolar organizer regions (NORs) in the house mouse: micro-evolutionary insights

2011

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Variation in the number and chromosomal location of nucleolar organizer regions (NORs) was studied in the house mouse, Mus musculus (2n¼40). From an origin in Western Asia, this species colonized the Middle East, Europe and Asia. This expansion was accompanied by diversification into five subspecies. NOR diversity was revealed by fluorescence in situ hybridization using 18S and 28S probes on specimens spanning Asia to Western Europe. The results showed that the house mouse genome possessed a large number of NOR-bearing autosomes and a surprisingly high rate of polymorphism for the presence/absence of rRNA genes on all these chromosomes. All NOR sites were adjacent to the centromere except for two that were telomeric. Subspecific differentiation established from the NOR frequency data was concordant with the overall pattern of radiation proposed from molecular studies, but highlighted several discrepancies that need to be further addressed. NOR diversity in M. musculus consisted of a large number of polymorphic NORs that were common to at least two subspecies, and a smaller number of NORs that were unique to one subspecies. The most parsimonious scenario argues in favor of a subspecific differentiation by lineage sorting of ancestral NOR polymorphisms; only the unique NORs would have appeared by interchromosomal transposition, except for the two telomeric ones that may have originated by hybridization with another species. Such a scenario provides an alternative view from the one prevailing in most systematic and phylogenetic analyses that NORs have a high transposition rate due to concerted evolution of rRNA genes.

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Section: Introductionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Chromosomal dynamics of nucleolar organizer regions (NORs) in the house mouse: micro-evolutionary insights

2011

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“…Interestingly, the M. m. molossinus strain MOLF carries a domesticus Y chromosome. Flow of mitochondrial DNA across subspecies boundaries 37 and discordant phylogenetic patterns between mitochondria and Y chromosome have been reported in wild population 19 , indicating that secondary introgression after radiation of the subspecies 20 might have contributed to the pattern of intersubspecific introgression observed in the wild-derived inbred strains, in addition to accidental "contamination" in the laboratory.…”

Section: Ancestry Of Classical Strainsmentioning

confidence: 89%

“…These features strongly suggest that the distorted patterns are due to introgression of haplotypes from a different subspecies in one, or more, of the reference strains indicating that the three wild derived strains may not be pure representatives of each subspecies. Intersubspecific introgression has been reported in wild mice and in wild-derived strains 16,[18][19][20] . Furthermore, MOLF, a wild-derived strain considered to be a representative of M. m. molossinus, carries a domesticus Y chromosome ( Supplementary Fig.…”

Section: Intersubspecific Introgressionmentioning

confidence: 99%

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On the subspecific origin of the laboratory mouse

et al. 2007

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The genome of the laboratory mouse is thought to be a mosaic of regions with distinct subspecific origins. We have developed a high-resolution map of the origin of the laboratory mouse by generating 25,400 phylogenetic trees in 100 kb intervals spanning the genome. On average 92% of the genome is of M. m. domesticus origin and the distribution of diversity is strikingly non random among the chromosomes. There are large regions of extremely low diversity, representing blind spots for studies of natural variation and complex traits, as well as hot spots of diversity. In contrast with the mosaic model we found that the majority of the genome has intermediate levels of variation of intrasubspecific origin. Finally, the wild-derived mouse strains that are supposed to represent different mouse subspecies show substantial intersubspecific introgression. This has serious implications for evolutionary studies that assume these are pure representatives of a given subspecies.Laboratory mice, the most popular model organism in mammalian genetics 1,2 , were derived from wild mice belonging to the Mus musculus species by an intricate process that included the generation of "fancy" mice in both Asia and Europe and a complex web of relationships among inbred strains 3 . Early studies demonstrated that the mitochondria and the Y chromosome present in many classical laboratory strains were derived from different subspecies, M. m. domesticus for the mitochondria and M. m. musculus for the Y chromosome 4,5 . Furthermore, the Y chromosome was introduced in the laboratory mouse through M. m. molossinus males 6 . Based on these findings, it was proposed that the genomes of inbred strains were a mosaic of regions with different subspecific origin 7 . Recently, the fine structure of such mosaic variation has been described 8 . This study reported that strain-to-strain comparisons revealed regions with extremely high variation spanning one third of the genome and regions with extremely low variation covering the remaining two thirds of the genome. This distinctively bimodal distribution was assumed to represent regions with the same and different subspecific origin. This mosaic model has been the driving concept behind mouse association mapping studies and haplotype analysis [9][10][11][12] . However, the origin of a given region of a laboratory strain could not be directly assigned to a subspecies due to the lack of reference sequences for the three major mouse subspecies. Subsequent studies raised questions regarding the haplotype structure 11,13 , the effect of ascertainment biases in subspecific assignment [14][15][16] and the contributions of intersubspecific

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Ring Species and Speciation

Blackmon,

Demuth

2012

Encyclopedia of Life Sciences

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A ring species is a monophyletic group whose range has extended around a geographic barrier to produce a ring‐shaped distribution. The populations that make up the ring should be contiguous and without barriers to gene flow anywhere in the ring except where the terminal populations are sympatric but reproductively isolated from one another. Few, if any of the species that have been described as ring species, actually meet all of these requirements. The best documented example of a species that exhibits all of these traits is the greenish warbler complex ( Phylloscopus trochiloides ). However, even species like the herring gull complex or Ensatina salamanders that fail to exhibit some of the characteristics of a true ring species offer opportunities to study important evolutionary processes. These species are particularly helpful in understanding how microevolutionary changes can create two unique species, how speciation can occur in spite of gene flow, and how geographic speciation with or without adaptive divergence can occur. Key Concepts: Few organisms exhibit all of the requirements to be considered a true ring species. Ring species are helpful tools that can be used to help elucidate evolutionary processes. The preponderance of avian and mammal ring species may be an ascertainment bias.

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Species-wide distribution of highly polymorphic minisatellite markers suggests past and present genetic exchanges among house mouse subspecies

Cited by 47 publications

References 30 publications

Chromosomal dynamics of nucleolar organizer regions (NORs) in the house mouse: micro-evolutionary insights

Chromosomal dynamics of nucleolar organizer regions (NORs) in the house mouse: micro-evolutionary insights

On the subspecific origin of the laboratory mouse

Ring Species and Speciation

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