Specific 1,25-dihydroxyvitamin D3 binding sites in choroid plexus

Walters, Marian R.; Fischette, Christine T.; Fetzer, Carole; May, Byron C.; Riggle, Paul C.; Tibaldo-Bongiorno, M.; Christakos, Sylvia

doi:10.1016/0014-2999(92)90697-3

Cited by 17 publications

(7 citation statements)

References 8 publications

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“…1982). Subsequent studies have confirmed the presence of VDR in both neuronal and glial cells of the limbic system, choroid plexus and several other brain regions (Walters et al . 1992; Baas et al .…”

mentioning

confidence: 80%

Cross‐talk of vitamin D and glucocorticoids in hippocampal cells

Obradovic

Gronemeyer

Lutz

et al. 2005

Journal of Neurochemistry

127

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There is growing evidence for a role of vitamin D3 signalling in the brain. In this study, we investigated the influence of vitamin D3, in combination with glucocorticoids, on differentiation of the hippocampal progenitor line HIB5, as well as survival of rat primary hippocampal cells. In HIB5, pre-treatment with dexamethasone (Dex) alone inhibited neurite outgrowth and abolished activation of the mitogen-activated protein kinase (MAPK) pathway during platelet-derived growth factor (PDGF)-induced differentiation, consistent with previous findings. Interestingly, pre-treating HIB5 with vitamin D3 significantly reduced these effects of Dex and, in addition, lowered the transactivational function of the glucocorticoid receptor (GR) in transient reporter gene assays. A further impact of vitamin D3 on glucocorticoid effects was observed in a rat primary hippocampal culture known to be particularly sensitive to prolonged GR activation. In this model, Dex induced considerable cell death after 72 h of exposure in vitro. However, 24 h of pre-treatment with low doses of vitamin D3 substantially reduced the degree of Dex-induced apoptosis in primary hippocampal cells. Taken together, our experiments demonstrate a cross-talk between vitamin D3 and glucocorticoids in two hippocampal models, a feature that may have important implications in disorders with dysregulated glucocorticoid signalling, including major depression.

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mentioning

confidence: 80%

Cross‐talk of vitamin D and glucocorticoids in hippocampal cells

Obradovic

Gronemeyer

Lutz

et al. 2005

Journal of Neurochemistry

127

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“…In addition, more than 50 calcitriol target tissues have been identified with either autoradiography [33] or with immunohistochemistry for the VDR protein [7,27,29]. Some of these tissues appear to have no direct impact on mineral homeostasis [12,13,26,27,39,40], and the function of the VDR within these regions remains uncertain in many cases.…”

Section: Introductionmentioning

confidence: 99%

Distribution of 1,25-Dihydroxyvitamin D3 Receptor Immunoreactivity in the Limbic System of the Rat

Walbert¹,

Jirikowski²,

Prüfer

2001

Horm Metab Res

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We used immunocytochemistry to obtain a complete cellular and subcellular mapping of the 1,25-dihydroxyvitamin D3 receptor protein (VDR) in the rat limbic system. We observed specific VDR immunostaining in the nucleus as well as in the perinuclear cytoplasm of neuronal cells. The limbic system consists of a variety of neuronal structures, and is known to have influence on memory, behavior, emotions and reproduction. In the hippocampal formation, we found strong nuclear staining as well as less distinguished cytoplasmic VDR staining in CA1, CA3 and CA4. The CA2 area showed a unique cytoplasmic predominance of VDR. The amygdala was found to exhibit specific patterns of VDR distribution in the various regions of the nucleus. We observed distinct differences of VDR localization within the limbic preoptic areas of the hypothalamus. Further parts of the brain we analyzed included the mammillary bodies, the indusium griseum and the cingulate cortex. The subcellular distribution of VDR in regions of the limbic system suggests a specific functional role of the receptor protein and indicates a role for calcitriol as a neuroactive steroid.

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“…Different abilities in the several plexuses for uptake of cholecalciferol may have been important for our observations, especially because binding sites for 1, 25-dihydroxyvitamin D3 have been described in mouse and calf choroid plexus [Walters et al 1992]. However, no pertinent data are available except that Suzuki et al studied uptake of cimetidine by lateral and fourth ventricular plexuses and found no differences in drug transport [Suzuki et al 1986].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, differences in development and histology of the several plexuses have been described in fetal rabbits and fetal humans [Tennyson 1975, Tennyson and Pappas 1964]. Also functional differences among the several choroid plexuses have been described [Harbut and Johanson 1986, Walters et al 1992]. In the present work, knowledge of the heterogeneity of choroid plexuses of rats has been extended.…”

Section: Introductionmentioning

confidence: 87%

Different inflammatory reactions to vitamin D3 among the lateral, third and fourth ventricular choroid plexuses of the rat

Levine

Saltzman

Ginsberg

2008

Experimental and Molecular Pathology

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The four choroid plexuses in the brain ventricles are not identical, but differences among them have rarely been studied. The present work concerns the inflammatory and hemorrhagic choroid plexitis produced in Lewis rats by a single gavage of cholecalciferol (vitamin D3) or related steroids with vitamin D activity. Plexitis was very severe in the fourth ventricular plexus, somewhat less severe in the lateral ventricular plexuses, and almost absent in the third ventricular plexus. These findings were compared to the scanty data from the literature on differences among the plexuses.

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Specific 1,25-dihydroxyvitamin D3 binding sites in choroid plexus

Cited by 17 publications

References 8 publications

Cross‐talk of vitamin D and glucocorticoids in hippocampal cells

Cross‐talk of vitamin D and glucocorticoids in hippocampal cells

Distribution of 1,25-Dihydroxyvitamin D3 Receptor Immunoreactivity in the Limbic System of the Rat

Different inflammatory reactions to vitamin D3 among the lateral, third and fourth ventricular choroid plexuses of the rat

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