Specific and common genes implicated across major mental disorders: A review of meta-analysis studies

Gatt, Justine M.; Burton, Karen; Williams, Leanne M.; Schofield, Peter R.

doi:10.1016/j.jpsychires.2014.09.014

Cited by 255 publications

(195 citation statements)

References 153 publications

(210 reference statements)

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“…While this may be due to insufficient power, an effect of APOE genotype on ADHD outcome in general has not been found (see (Gatt et al. 2015) for meta‐analyses), although these studies were conducted on healthy referents and may not be transferable to CHD populations. A previous study (Gaynor et al.…”

Section: Discussionmentioning

confidence: 99%

Organizational topology of brain and its relationship to ADHD in adolescents with d‐transposition of the great arteries

et al. 2016

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ObjectiveLittle is currently known about the impact of congenital heart disease (CHD) on the organization of large‐scale brain networks in relation to neurobehavioral outcome. We investigated whether CHD might impact ADHD symptoms via changes in brain structural network topology in a cohort of adolescents with d‐transposition of the great arteries (d‐TGA) repaired with the arterial switch operation in early infancy and referent subjects. We also explored whether these effects might be modified by apolipoprotein E (APOE) genotype, as the APOE ε2 allele has been associated with worse neurodevelopmental outcomes after repair of d‐TGA in infancy.MethodsWe applied graph analysis techniques to diffusion tensor imaging (DTI) data obtained from 47 d‐TGA adolescents and 29 healthy referents to construct measures of structural topology at the global and regional levels. We developed statistical mediation models revealing the respective contributions of d‐TGA, APOE genotype, and structural network topology on ADHD outcome as measured by the Connors ADHD/DSM‐IV Scales (CADS).ResultsChanges in overall network connectivity, integration, and segregation mediated worse ADHD outcomes in d‐TGA patients compared to healthy referents; these changes were predominantly in the left and right intrahemispheric regional subnetworks. Exploratory analysis revealed that network topology also mediated detrimental effects of the APOE ε4 allele but improved neurobehavioral outcomes for the APOE ε2 allele.ConclusionOur results suggest that disruption of organization of large‐scale networks may contribute to neurobehavioral dysfunction in adolescents with CHD and that this effect may interact with APOE genotype.

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Section: Discussionmentioning

confidence: 99%

Organizational topology of brain and its relationship to ADHD in adolescents with d‐transposition of the great arteries

et al. 2016

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“…The short allelic variant has been linked to a lower transcriptional rate of the gene and diminished functional capacity of serotonin transporter protein, resulting in reduced serotonin reuptake-and consequently higher serotonin levels-in the synaptic cleft [17]. Considering the functional relevance of this polymorphism, it has been studied as a risk marker across different psychiatric disorders, including major depression and obsessive-compulsive disorder, and thus may be particularly relevant for the present inquiry focused on ADHD (for a review, see [18]). In fact, a number of studies document associations between the 5-HTTLPR genotype and symptoms of inattention, with evidence indicating that children with at least one s-allele, and particularly those homozygous for this allele, evince elevated levels of ADHD symptoms [19][20][21].…”

Section: Genetics and Adhdmentioning

confidence: 99%

Serotonin transporter polymorphism moderates the effects of caregiver intrusiveness on ADHD symptoms among institutionalized preschoolers

Baptista

Belsky

Mesquita

et al. 2016

Eur Child Adolesc Psychiatry

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“…Perhaps the best way to do this is found in the approach of a recent review of meta-analyses, which examined 329 candidate genes for five major disorders (unipolar depression, bipolar disorder, schizophrenia, anxiety disorders, and attention deficit hyperactivity disorder (ADHD), and found 13 genetic variants that were associated with at least two different disorders (Gatt 2015). Among these 13 genes were both MTHFR polymorphisms, A1298C and C677T, which indicates that the relationship between these polymorphisms is likely real, with a pleiotropic mechanism that leads to the inconsistent results seen in the literature today (Gatt 2015). As progress is made in understanding the big picture of genetic interactions and their impact on mental illness, the apparent contradictions produced by crude analysis of only two variables will likely be resolved.…”

Section: Multi-axial Diagnosesmentioning

confidence: 99%

Severe Mood Lability and Depression in an Adolescent Girl with a Methylenetetrahydrofolate Reductase Gene Mutation

Brown

Panuganti²,

Rais³

2017

IJCRR

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Abstract:Methylenetetrahydrofolate Reductase (MTHFR), an enzyme that controls the rate of production of N-methyltetrahydrofolate(a molecule which is necessary for the N-methyltetrahydrofolatehomocysteinemethyltransferase reaction),is vital for many of the human body's biological processes, including DNA and RNA synthesis.Mutations in the MTHFR gene, which have far reaching effects on the negative feedback systems that regulate nucleic acid synthesis (via thymidylate synthesis)and homocysteinelevels,are believed to beof clinical significance and have been widely studied. The neurological and neuropsychiatric consequences of these changes have been long suspected but have only recently begun to be characterized. In this case report we discuss M., a fourteen-year-old Caucasian girl with a past diagnosis of major depressive disorder, and a recent history of suicide attempt by overdose, who presented for inpatient hospitalization after attempting to drown herself in a bathtub. A psychiatric history revealed that the patient developed severe depression and mood lability after her fourteenth birthday, which rapidly progressed to suicidal thoughts and two suicide attempts, and it was discovered upon taking a medical history and ordering genetic testing that she carried two MTHFR mutations, in locations where polymorphisms are suspected to correlate to mental illness generally and to mood disorders specifically.

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Specific and common genes implicated across major mental disorders: A review of meta-analysis studies

Cited by 255 publications

References 153 publications

Organizational topology of brain and its relationship to ADHD in adolescents with d‐transposition of the great arteries

Organizational topology of brain and its relationship to ADHD in adolescents with d‐transposition of the great arteries

Serotonin transporter polymorphism moderates the effects of caregiver intrusiveness on ADHD symptoms among institutionalized preschoolers

Severe Mood Lability and Depression in an Adolescent Girl with a Methylenetetrahydrofolate Reductase Gene Mutation

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