Specific antagonism by RO 15-1788 of benzodiazepine-induced increases in food intake in rhesus monkeys

Foltin, Richard W.; Ellis, Susan; Schuster, Charles R.

doi:10.1016/0091-3057(85)90565-9

Cited by 41 publications

(17 citation statements)

References 19 publications

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“…The current Þnding is consistent with a lack of ßumazenil-induced hyperphagia in rats and primates when presented food during scheduled feeding tests (Cooper and Moores 1985;Foltin et al 1985). In contrast, high doses (10.030.0 mg / kg) of ßumazenil increased free-feeding in squirrel monkeys within the social group (Weerts et al 1993), enhanced the consumption of sweetened milk in non-deprived rats (Cooper, personal communication) and increased consumption of NaCl solution in rehydrating rats (Falk and Tang 1984).…”

Section: Discussionsupporting

confidence: 89%

“…The hyperphagic e¤ects of bretazenil are consistent with its classiÞcation as a benzodiazepine partial agonist. The original observation that the benzodiazepine full agonist CDP produced hyperphagia in rats (Randall et al 1960) has been conÞrmed and extended to include other benzodiazepine full agonists and partial agonists in rats (Cooper and Francis 1979;Berridge and Treit 1986;Cooper 1987b;Yerbury and Cooper 1987) and primates (Foltin et al 1985(Foltin et al , 1989. Bretazenil has been reported to match the maximal hyperphagic e¤ects of benzodiazepine full agonists at lower doses in non-deprived rats Yerbury and Cooper 1987).…”

Section: Discussionmentioning

confidence: 94%

“…In addition to increasing food consumption, benzodiazepines enhance appetitive behaviors such as orienting towards and approaching food containers (Nieto and Posadas-Andrews 1984). Benzodiazepine-induced increases in feeding can be prevented by the benzodiazepine receptor antagonist, ßumazenil (0.51.0 mg / kg) indicating that this e¤ect is mediated via the benzodiazepine receptor (Foltin et al 1985).…”

Section: Introductionmentioning

confidence: 98%

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Dissociation of consummatory and vocal components of feeding in squirrel monkeys treated with benzodiazepines and alcohol

1998

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The primary aim of the current experiments was to develop methods that engender vocalizations associated with positive social situations comprising affiliative behavior and feeding that could be quantified under controlled laboratory conditions and were sensitive to anxiolytic drugs. Classical conditioning procedures were used to elicit vocalizations during presentation of stimulus lights (i.e., CS condition) previously paired with either preferred foods (e.g., grapes, peanuts, bananas) or standard foods (e.g., monkey chow) as well as during presentation of both food types (i.e., UCS condition). When compared to the period before stimulus light presentation (i.e., Pre-CS condition), the rate, duration and number of elemental units of food-related "twitter" vocalizations were increased during the CS conditions regardless of food type. Monkeys spent significantly more time oriented toward the food box during the light stimulus that preceded preferred food than for the light stimulus that preceded standard food. However, twitter vocalizations were higher for standard food regardless of the stimulus conditions (i.e., Pre-CS, CS and UCS). Administration of the benzodiazepine full agonist chlordiazepoxide (CDP, 1-10 mg/kg), the partial agonist bretazenil (BRZ, 1-10 mg/kg), the antagonist flumazenil (FLZ, 1-10 mg/kg) and ethyl alcohol (EtOH, 0.1-1.0 g/kg) differentially altered vocalizations. Although CDP and BRZ increased feeding of standard food, twitters were reduced across stimulus conditions. CDP and BRZ did not alter other social contact calls (i.e., "peeps"). FLZ also reduced twitters without altering peeps, but did not increase feeding. In contrast, EtOH did not increase feeding or peeps, but did increase food-related twitters. These results indicate that there is a dissociation between food-related behaviors, such as food consumption and orientation towards the food source, and vocal behaviors associated with group communication during feeding.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 98%

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Dissociation of consummatory and vocal components of feeding in squirrel monkeys treated with benzodiazepines and alcohol

1998

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“…This hyperphagia is blocked by the central benzodiazepine receptor antagonist, ßumazenil, demonstrating that the e¤ect is receptor-speciÞc (Foltin et al 1985;Mansbach et al 1985). Despite the range of non-human animal data, and despite the number of individuals prescribed these compounds, the e¤ect of benzodiazepines on food intake in humans has not been fully described.…”

Section: Introductionmentioning

confidence: 94%

Alprazolam increases food intake in humans

et al. 1997

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The present study investigated the effect of alprazolam on the pattern of food intake in seven male participants living in a residential laboratory for 17 days. A wide selection of meals, snacks and beverages was freely available. Capsule administration occurred at 1300 and 1730 hours. Food intake on days when alprazolam (0.75 mg) was administered (days 2, 11) was compared to days when no capsule (days 1, 9) or placebo (days 3, 10) was administered. Alprazolam increased total caloric intake by approximately 975 kcal from a baseline of 2800 kcal. Alprazolam increased the number of eating occasions occurring in the evening (1700-2330 hour), without altering the size of eating occasions (kcal), or the proportion of total calories derived from carbohydrate, fat and protein. These data demonstrate alprazolam's robust effects on food intake in humans.

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“…Increases in the consumption of food following the administration of benzodiazepine receptor agonists are blocked by the benzodiazepine antagonist Rol 5-1788 (Cooper and Gilbert 1985; Foltin et al 1985;Mansbach et al 1984). Inverse agonists acting at benzodiazepine sites would be expected to reduce food intake.…”

Section: Resultsmentioning

confidence: 98%

Benzodiazepine receptor-mediated effect of CGS 8216 on milk consumption in the non-deprived rat

Estall

Cooper

1986

Psychopharmacology

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The pyrazoloquinoline CGS 8216, which binds with high affinity to central benzodiazepine recognition sites, produced a highly significant reduction in the consumption of familiar, sweetened milk by non-deprived male rats, when administered in a dose of 20 mg/kg, IP. The anorectic effect was present during the first 5 min period of a 20-min drinking test, and remained in evidence throughout the remainder of the test. The benzodiazepine receptor antagonist Ro15-1788, administered 15 min before the consumption test, produced a dose-related (10-40 mg/kg, IP) reversal of the anorectic effect of CGS 8216, during the first 10 min of the test. Injection of Ro15-1788 alone had no significant effect on milk ingestion. This experiment shows that the reduction in the consumption of a palatable liquid food by CGS 8216 can be attributed to an action at benzodiazepine receptors. The result is consistent with the characterization of CGS 8216 as a weak benzodiazepine receptor inverse agonist.

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Specific antagonism by RO 15-1788 of benzodiazepine-induced increases in food intake in rhesus monkeys

Cited by 41 publications

References 19 publications

Dissociation of consummatory and vocal components of feeding in squirrel monkeys treated with benzodiazepines and alcohol

Dissociation of consummatory and vocal components of feeding in squirrel monkeys treated with benzodiazepines and alcohol

Alprazolam increases food intake in humans

Benzodiazepine receptor-mediated effect of CGS 8216 on milk consumption in the non-deprived rat

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