Specific antibodies against methyltetrahydrophthalic anhydride and risk factors for sensitization in occupationally exposed subjects

Yokota, Kozo; Johyama, Yasushi; Yamaguchi, Kyohei; Fujiki, Yukio; Takeshita, Tatsuya; Morimoto, Kanehisa

doi:10.5271/sjweh.201

Cited by 23 publications

(13 citation statements)

References 17 publications

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“…10 Similar high frequencies of specific IgE antibody detection have been reported for tetrachlorophthalic anhydride (TCPA) and methyltetrahydrophthalic anhydride (MTHPA), with each of seven cases of TCPA-induced occupational asthma displaying specific IgE antibody 11 and 63% of MTHPAexposed workers testing positive for specific IgE and a significant correlation between work-related ocular or nasal symptoms and the detection of MTHPA-specific IgE antibody. 12 For other acid anhydrides, such as phthalic anhydride (PA) and maleic anhydride (MA), the evidence for IgE-mediated disease is less compelling. Published reports of patients with measurable anti-MA IgE antibody are sparse, with one patient reported with low levels of specific IgE antibodyinvestigations, however, a further seven individuals with respiratory symptoms and occupational exposure to MA and other acid anhydrides failed to display detectable anti-MA IgE antibody.…”

Section: Introductionmentioning

confidence: 99%

Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides

Dearman

Filby

Humphreys

et al. 2002

J of Applied Toxicology

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There is some debate regarding whether occupational asthma induced by respiratory sensitizing acid anhydrides is mediated by the induction of T helper (Th) 2-type responses and the production of IgE, with failure to detect specific IgE antibody in some symptomatic patients. In the current investigations, cytokine secretion profiles induced in draining lymph node cells (LNC) by topical application to BALB/c strain mice of trimellitic anhydride (TMA), phthalic anhydride (PA) and maleic anhydride (MA) have been examined. Responses were compared with those induced by exposure to 2,4-dinitrochlorobenzene (DNCB), a contact allergen that lacks respiratory sensitizing potential. Exposure to all three acid anhydrides stimulated vigorous expression of interleukin (IL)-5, IL-10 and IL-13 but relatively low levels of the type 1 cytokines interferon-gamma (IFN-gamma) and IL-12. In addition, TMA-activated LNC expressed high levels of mitogen-inducible IL-4 whereas MA and PA displayed a lesser potential to elaborate this cytokine. The DNCB-stimulated LNC exhibited the converse type 1 phenotype of cytokine expression. The CD4(+) Th2 cells were the primary source of type 2 cytokines. Respiratory sensitizing acid anhydrides induce a predominantly Th2 cytokine phenotype, including the expression of IL-5 and IL-13, cytokines which in the presence of only very low levels of IL-4 may provide for an IgE-independent mechanism for the development of chemical respiratory allergy. These data provide additional support for the use of cytokine secretion profiling for the prospective identification of chemical respiratory allergens.

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Section: Introductionmentioning

confidence: 99%

Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides

Dearman

Filby

Humphreys

et al. 2002

J of Applied Toxicology

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“…Welinder et al 12) stated that 5 of 7 workers positive for HHPA-specific IgE in the group with lowest exposures reported frequent shorttime (minutes per day) exposures exceeding 50 µg/m 3 . In our previous study of a condenser plant using MTHPA 17) , no significant differences were found in the frequency of positive specific IgE or work-related symptoms between workers continuously and intermittently exposed. These findings indicate that short-time peak exposures may have a great impact on the development of specific IgE or workrelated symptoms.…”

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Survey of 32 Workers Exposed to Hexahydrophthalic and Methylhexahydrophthalic Anhydrides.

2002

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Abstract:The relation between exposure and sensitization or the appearance of symptoms of the eyes and airways was investigated in a cross-sectional study on 32 workers from a plant using epoxy resin with a mixture of hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA) as a hardener. The main component in the hardener was HHPA, and the geometric mean concentrations of HHPA in the workplaces were extremely low (<40 µg/m 3 ) in recent years, compared to the Occupational Exposure Limit-Ceiling for phthalic anhydride (2 mg/m 3 ). However, specific IgE antibody to HHPA was detected in serum from 8 (25%) out of the workers: of those, 5 workers experienced symptoms of the eyes and nose during work (group sensitized symptomatic (SS)) and 3 workers did not (group sensitized nonsymptomatic (SN)). The other 24 workers had no signs of sensitization and did not complain of work-related symptoms. Based on occupational history and anamnestic data, it was concluded that one subject in the SS group and all the subjects in the SN group had been sensitized by higher exposures in the past. The symptoms of 4 subjects in the SS group occurred only when carrying out short-time, particular tasks (15-30 min) a few times a day, such as the resin mixing procedures, manual application of the resin, or opening of ovens. High peak exposures were estimated to have occurred during the particular tasks. Our results suggest that short-time peak exposures may have a great impact on the development of specific IgE or work-related symptoms. Therefore, to minimize the risk of sensitization and work-related symptoms, a reduction of exposure during particular tasks with high peak exposures, along with a decrease in mean 8-h time-weighted average exposure, should be achieved.

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“…In occupational environments a history indicating an immediate-type of allergy without demonstrable specific IgE has been observed among bakers (Kraut et al 1992). In studies of allergy caused by phthalic anhydrides, an association has been suspected between IgG 4 antibodies and hypersensitivity symptoms (Nielsen et al 1988;Nordman et al 1987) or phtalic anhydride allergy (Pakarinen et al 2002), but also studies on the same topic have been published that have not shown any association (Yokota et al 1997). …”

Section: Introductionmentioning

confidence: 96%

IgG4 response to fur animal allergens among fur workers

Uitti

Nordman

Halmepuro

et al. 2004

Int Arch Occup Environ Health

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Specific antibodies against methyltetrahydrophthalic anhydride and risk factors for sensitization in occupationally exposed subjects

Abstract: The following articles refer to this text: 2001;27(2): 133-139; 2003;29(4):297-303

Cited by 23 publications

References 17 publications

Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides

Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides

A Cross-Sectional Survey of 32 Workers Exposed to Hexahydrophthalic and Methylhexahydrophthalic Anhydrides.

IgG4 response to fur animal allergens among fur workers

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