1961
DOI: 10.1016/s0140-6736(61)92066-9
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Specific Antibodies in Heart-Disease

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Cited by 74 publications
(13 citation statements)
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“…In previous experimental studies we were not able to show a relationship between the presence of circulating anti-heart antibodies and myocardial damage [10]. This has also been the case in a number of different clinical studies of other diseases [11,12]. However, the elution of anti-heart antibodies from the myocardium in cases of heart transplantation where an immune reaction existed [13], as well as the results of immunofluorescent studies where bound anti-heart antibodies were found [14] are suggestive of a relationship between the presence of these antibodies and myocardial damage.…”
Section: Discussionmentioning
confidence: 72%
“…In previous experimental studies we were not able to show a relationship between the presence of circulating anti-heart antibodies and myocardial damage [10]. This has also been the case in a number of different clinical studies of other diseases [11,12]. However, the elution of anti-heart antibodies from the myocardium in cases of heart transplantation where an immune reaction existed [13], as well as the results of immunofluorescent studies where bound anti-heart antibodies were found [14] are suggestive of a relationship between the presence of these antibodies and myocardial damage.…”
Section: Discussionmentioning
confidence: 72%
“…A question arises as to whether limited sensitivity is a methodical matter, or whether it concerns a lower ability of dogs to respond immunologically to artificial necrosis. Finally, E hrenfeld et al [15] have found antibodies against myocardium in only 24 of 150 patients by means of the passive hemagglutination method. D avies and G ery [16] have studied the possibility of patients' serum reaction on antigenic heart tissue in various types of heart diseases and came to the conclusion, that only a limited number of people had ability to form circulating antibody.…”
Section: Discussionmentioning
confidence: 99%
“…Although no mention was made of clinical effects, histologic changes similar to those described above were noted. The presence of circulating autoantibodies to heart have been described in a number of cardiac disorders in man including the post myocardial infarction and post pericardiotomy syndrome [3,10,11], myocardial infarction [4] and rheumatic fever [5,8]. No abnormality as a result of these antibodies has been established.…”
Section: Discussionmentioning
confidence: 99%