Specific antibody to Haemophilus somnus in the bovine uterus following intramuscular immunization

Butt, B M; Besser, Thomas E.; Senger, P. L.; Widders, P. R.

doi:10.1128/iai.61.6.2558-2562.1993

Cited by 13 publications

(4 citation statements)

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“…IgA is made at the mucosal surface of the bovine uterus. The endometrium produces half of the IgG1 fraction, while the balance of the IgG1 and all of the IgG2 come from the peripheral circulation ( 63 ) ( Figure 3 ).…”

Section: Economic Consequences Of Immunoinfertilitymentioning

confidence: 99%

Bovine reproductive immunoinfertility: pathogenesis and immunotherapy

Gupta,

Mohanty,

Bhakat

et al. 2023

Front. Vet. Sci.

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Infertility is one of the primary factors for cattle reproduction in the present scenario. Reproduction-related immunoinfertility mainly involves immunization against the antigens related to reproductive hormones (LHRH, GnRH, Gonadal steroids, PGF2α and oxytocin), spermatozoa, seminal plasma and ovum. Anovulation, delayed ovulation, sperm immobilization, failure of fertilization, prolonged uterine involution, extended calving interval, prolonged post-partum estrus and reduced conception rate could be a result of immunoinfertility that occur due to the blockage of receptor site by antibodies formed against hormones, sperm and ovum. Immunoinfertility can be treated in the animal by giving sexual rest to females, by using various reproductive technologies such as in-vitro fertilization, gamete intra fallopian tube transfer, and intracytoplasmic sperm injection, sperm washing and by treating the animals with immunomodulators such as LPS, Oyster glycogen, etc. This review summarizes the different causes of bovine reproductive immunoinfertility and amelioration strategies to overcome it.

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Section: Economic Consequences Of Immunoinfertilitymentioning

confidence: 99%

Bovine reproductive immunoinfertility: pathogenesis and immunotherapy

Gupta,

Mohanty,

Bhakat

et al. 2023

Front. Vet. Sci.

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“…Admittedly, the correlation between circulating and intrauterine NAb levels is not known; however, previous studies have suggested that most of the immunoglobulins found in the uterine secretion of cattle are serum derived (Corbeil et al, 1974;Butt et al, 1993). The idea that antibodies may play an important role in uterine disease resistance is partly supported by a previous study, in which it was reported that systemic immunization against important intrauterine pathogens increased blood levels of specific antibodies and decreased the incidence of puerperal metritis (Machado et al, 2014).…”

Section: Short Communicationmentioning

confidence: 99%

Short communication: Relationship between natural antibodies and postpartum uterine health in dairy cows

Machado

Bicalho

Gilbert

2014

Journal of Dairy Science

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Postpartum uterine diseases of dairy cows compromise animal welfare and may result in early removal from the herd or impaired reproductive performance. The relationship between poor immune status around calving and uterine diseases is well established; however, that between natural antibodies (NAb) and uterine health has not yet been studied. The objective of this study was to evaluate the association of circulating NAb levels around parturition with puerperal metritis, clinical endometritis, and the intrauterine presence of the Escherichia coli virulence factor FimH. One hundred six pregnant heifers were enrolled; NAb in serum samples collected at 30 ± 3 d prepartum and at 2 ± 1 and 35 ± 3 d in milk (DIM) were measured by ELISA. Puerperal metritis was defined as the presence of fetid, watery, red-brown uterine discharge and rectal temperature >39.5°C at 6 ± 1 DIM. Clinical endometritis was defined as presence of pus in the uterine lavage sample collected at 35 ± 3 DIM. The intrauterine presence of the fimH gene at 2 ± 1 DIM was evaluated by PCR. The overall optical density (wavelength of 650 nm) of ELISA-detected serum NAb was lower for cows diagnosed with puerperal metritis than for cows that did not have puerperal metritis. Additionally, cows diagnosed with clinical endometritis tended to have lower levels of NAb than did cows without clinical endometritis. Finally, FimH-positive cows had lower overall levels of serum NAb compared with FimH-negative cows. In conclusion, NAb detected in serum around parturition was associated with uterine health of dairy cows.

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“…Data showing the ability of vaccination to protect against abortion is lacking,56 although the development of a systemic IgG 2 antibody response may provide local immunological protection in the uterus. 13 Like all bacterins, protection from clinical disease is short-lived at best; therefore, a minimum of two primary vaccinations given at month intervals and at least annual boosters would be needed to provide even theoretical protection in those herds where the disease has been demonstrated.…”

Section: Vaccination Protocolmentioning

confidence: 99%

Heifer Development

Larson

2000

American Association of Bovine Practitioners Proceedings of the Annual Conference

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Replacement heifer development is a critically important area for veterinarians to offer production medicine advice to their beef-producing clients. Productivity for beef cattle herds has been shown to increase when a high percentage of heifers become pregnant early in the first breeding season.55 A producer's heifer development program should result in most heifers in the replacement pool reaching puberty at least 42 days prior to the start of breeding because the conception rate to first service is lower on the pubertal estrus compared to the third estrus.14,80 Many producers put additional pressure on heifers to reach puberty at a young age by breeding them 3 to 4 weeks earlier than the mature cow herd. The stress of calving is greater on heifers than older cows, and more likely accompanied by calving difficulty. Thus, breeding replacement heifers essentially one heat cycle earlier than the mature cows allows the producer to concentrate on the heifers at calving. In addition, the length of time from calving to the resumption of cycling is longer in heifers than in cows.98 Therefore, calving heifers earlier than mature cows gives the heifers the extra time they need to return to estrus and be cycling at the start of the subsequent breeding season. In order for heifers to reach puberty by 12 to 13 months of age they must receive adequate nutritional intake to signal the body that the "luxury" of reproduction is attainable. Once puberty is attained, nutrition must be at a level that allows the heifer to continue cycling, ovulate a viable oocyte, and establish pregnancy. Nutritional demands of heifers during pregnancy exceed that of mature cows because the heifer is partitioning nutrients for her own growth as well as fetal growth and development. This increased demand for nutrients continues through early lactation, when the beef female has her highest nutritional requirements. Deficiency of energy or protein for extended periods in any production phase during the first two and one-half years of life will impact negatively on fetal development, calf viability, milk production and/or rebreeding for the next pregnancy.

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Specific antibody to Haemophilus somnus in the bovine uterus following intramuscular immunization

Cited by 13 publications

References 14 publications

Bovine reproductive immunoinfertility: pathogenesis and immunotherapy

Bovine reproductive immunoinfertility: pathogenesis and immunotherapy

Short communication: Relationship between natural antibodies and postpartum uterine health in dairy cows

Heifer Development

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