Specific aptamer-conjugated mesoporous silica–carbon nanoparticles for HER2-targeted chemo-photothermal combined therapy

Wang, Kaiyuan; Yao, Hui; Meng, Ying; Wang, Yi; Yan, Xueying; Huang, Rongqin

doi:10.1016/j.actbio.2015.01.002

Cited by 98 publications

(40 citation statements)

References 30 publications

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“…PEG served as a linker between amine-functionalized MSCN and thiol group-modified HB5. The results verified higher cytotoxicity of the combined therapy compared to chemo-or photo-therapy alone [206].…”

Section: Thiol Maleiimide and Related Chemistrysupporting

confidence: 58%

Aptamers Chemistry: Chemical Modifications and Conjugation Strategies

et al. 2019

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Soon after they were first described in 1990, aptamers were largely recognized as a new class of biological ligands that can rival antibodies in various analytical, diagnostic, and therapeutic applications. Aptamers are short single-stranded RNA or DNA oligonucleotides capable of folding into complex 3D structures, enabling them to bind to a large variety of targets ranging from small ions to an entire organism. Their high binding specificity and affinity make them comparable to antibodies, but they are superior regarding a longer shelf life, simple production and chemical modification, in addition to low toxicity and immunogenicity. In the past three decades, aptamers have been used in a plethora of therapeutics and drug delivery systems that involve innovative delivery mechanisms and carrying various types of drug cargos. However, the successful translation of aptamer research from bench to bedside has been challenged by several limitations that slow down the realization of promising aptamer applications as therapeutics at the clinical level. The main limitations include the susceptibility to degradation by nucleases, fast renal clearance, low thermal stability, and the limited functional group diversity. The solution to overcome such limitations lies in the chemistry of aptamers. The current review will focus on the recent arts of aptamer chemistry that have been evolved to refine the pharmacological properties of aptamers. Moreover, this review will analyze the advantages and disadvantages of such chemical modifications and how they impact the pharmacological properties of aptamers. Finally, this review will summarize the conjugation strategies of aptamers to nanocarriers for developing targeted drug delivery systems. Molecules 2020, 25, 3 2 of 51 molecules [2]. Nowadays, the aptamer field covers various biomedical applications, including [3], therapeutic [4-6], aptasensors [7], biosensors [8,9], diagnostic [10,11], and imaging systems [12].Aptamers need to be stabilized for in vivo use against nuclease degradation, and their small size makes them susceptible to renal filtration. Aptamers' stabilization can be attained by chemically modifying them using different approaches. Moreover, introducing chemical modifications into nucleic acid libraries increases the interaction capabilities of aptamers and thereby their target spectrum [12]. Modified aptamers may show improved chemical diversity relative to aptamers composed entirely of natural DNA or RNA nucleotides and expand their applications in diagnostics, therapeutics, and nanotechnology [1].Chemical modifications of aptamer oligonucleotides are needed mainly to enhance their resistance to nuclease degradation and lowering their renal filtration. Additionally, chemical modifications, in some cases, may increase the aptamer-binding affinity [13]. Many approaches have been introduced to promote the stability of aptamers without altering their binding affinity and specificity against their targets. These approaches include chemical modification of the phosphate...

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Section: Thiol Maleiimide and Related Chemistrysupporting

confidence: 58%

Aptamers Chemistry: Chemical Modifications and Conjugation Strategies

et al. 2019

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“…As for stimuli responsive systems, especially Near-Infrared (NIR) triggered multifunctional organic-inorganic hybrid silica nanoparticles are commonly used as cancer theranostics. Gold nanorods (GNRs) as cores of nanoshells [74], gold layers in core-shell nanoplatforms, gold nanocages [75], graphene nanosheets [76], graphitic [77] / semi-graphitic carbon cores [63] and CuS nanoparticles [78,79] and some other copper compounds [80] are the mostly studied NIR-absorbing agents in NIR-triggered hybrid silica nanocarriers. Photothermal therapy (PTT) employs near-infrared (NIR) laser photo-absorbers to generate heat upon NIR laser irradiation.…”

Section: Organic-inorganic Hybrid Silicas With Target-ligand Interactmentioning

confidence: 99%

“…design of targeted drug delivery systems [63]. The differential expressions of receptor proteins, residing in cytosol, organelles or membrane are used as molecular markers.…”

Section: Theranostic Approachmentioning

confidence: 99%

Silica‐based organic‐inorganic hybrid nanoparticles and nanoconjugates for improved anticancer drug delivery

Ilhan‐Ayisigi

Yeşil-Çeliktaş

2018

Engineering in Life Sciences

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After the introduction of first generation MSNs for drug delivery with some challenges such as large particle sizes, irregular morphologies and aggregations, second generation provided uniform spherical morphologies, tunable pore/particle sizes and compositions. Henceforth, organic‐inorganic hybrid mesoporous silica nanosystems have grown rapidly and utilized for active and passive targeting of tumorigenic cells especially conjugated with organic polymers followed by third generation counterparts with improved functionalities for cancer therapy. The aim of this review article is to focus on the advancements in mesoporous silica based organic‐inorganic hybrid nanoparticles developed as drug carriers targeting cancer cells. Brief introduction to the state‐of‐the‐art in passive and active targeting methods is presented. Specifically, therapeutic, diagnostic and theranostic applications are discussed with emphases on triggered and ligand conjugated organic‐inorganic hybrid mesoporous silica nanomaterials. Although mesoporous silica nanoparticles perform well in preclinical tests, clinical translation progresses slowly as appropriate doses needs to be evaluated for human use along with biocompatibility and efficiency depending on surface modifications.

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“…In one example, reported by Wang et al, the human epithelial growth factor receptor 2 (HER2) HB5 aptamer 5'-(AAC CGC CCA AAT CCC TAA GAG TCT GCA CTT GTC ATT TTG TAT ATG TAT TTG GTT TTT GGC TCT CAC AGA CAC ACT ACA CAC GCA CA)-3' was successfully grafted onto DOX-loaded semigraphitized carbon containing MSNs. 84 In this case the authors included PEG for stealthiness purposes although did not incorporate any gating system onto the device; so the DOX release was then continuous and accelerated when pH decreased. Nevertheless, the evaluation of those HB5-modified MSNs in vivo against SK-BR-3 tumour-bearing mice showed a significant reduced toxicity.…”

Section: Aptamer-msns Hybrids For Active Targetingmentioning

confidence: 99%

Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors

Castillo¹,

Baeza²

2017

Biomater. Sci.

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The discovery and control of the biological roles mediated by nucleic acids have turned them into a powerful tool for the development of advanced biotechnological materials. Much is the importance of those gene-keeping biomacromolecules that even nanomaterials have succumbed to the claimed benefits of DNA and RNA. Currently, there could be found in the literature a practically intractable number of examples which report the use in combination of nanoparticles with nucleic acids, which demands boundedness. Following this premise, this revision will only cover the most recent and powerful strategies developed to exploit the possibilities of nucleic acids as biotechnological materials when in combination with mesoporous silica nanoparticles. The extensive research done on nucleic acids has significantly incremented the technological possibilities for those biomacromolecules, which could be employed in many different applications; where substrate or sequence recognition or modulation of biological pathways due to its coding role in living cells are the most promising. In the present revision, the chosen counterpart, mesoporous silica nanoparticles, also with unique properties, became a reference material for drug delivery and biomedical applications due to their high biocompatibility and porous structure suitable for hosting and delivering small molecules. Although most of revisions deal with significant advances in the use of nucleic acid and mesoporous silica nanoparticles in biotechnological applications, a rationale classification of those new generation hybrid materials is still uncovered. Along this review there will be covered promising strategies for living cell and biological sensors, DNA-based molecular gates with targeting, transfection or silencing properties which could provide a significant advance of current nanomedicine.

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Specific aptamer-conjugated mesoporous silica–carbon nanoparticles for HER2-targeted chemo-photothermal combined therapy

Cited by 98 publications

References 30 publications

Aptamers Chemistry: Chemical Modifications and Conjugation Strategies

Aptamers Chemistry: Chemical Modifications and Conjugation Strategies

Silica‐based organic‐inorganic hybrid nanoparticles and nanoconjugates for improved anticancer drug delivery

Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors

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