Specific binding of Hg2+ to mismatched base pairs involving 5-hydroxyuracil in duplex DNA

We are deeply grateful to the mentorship and friendship of Professor Nadrian C. Seeman, who passed away during the writing of this manuscript, and whose foundational work and guidance to DNA Nanotechnology was a light to all DNA double helices containing metal-mediated DNA (mmDNA) base pairs are constructed from Ag + and Hg 2+ ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials is impractical without a complete lexical and structural description. Here, the programmability of structural DNA nanotechnology toward its founding mission of self-assembling a diffraction platform for biomolecular structure determination is explored. The tensegrity triangle is employed to build a comprehensive structural library of mmDNA pairs via X-ray diffraction and generalized design rules for mmDNA construction are elucidated. Two binding modes are uncovered: N3-dominant, centrosymmetric pairs and major groove binders driven by 5-position ring modifications. Energy gap calculations show additional levels in the lowest unoccupied molecular orbitals (LUMO) of mmDNA structures, rendering them attractive molecular electronic candidates.

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Metal‐Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction

Vecchioni

Livernois

et al. 2023

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Specific binding of Hg2+ to mismatched base pairs involving 5-hydroxyuracil in duplex DNA

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Metal‐Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction

Metal‐Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction

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