Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway

Sampath, Chethan; Rashid, Muhammed Raihan; Sang, Shengmin; Ahmedna, Mohamed

doi:10.1016/j.foodchem.2017.01.056

Cited by 74 publications

(51 citation statements)

References 39 publications

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“…Intraperitoneal treatment of [6]-gingerol (3 or 75 mg/kg bw) for 8 weeks demonstrated antihyperglycemic (10%), cardioprotective potential, improved post-prandial glucose utilization and insulin sensitivity in STZ-induced diabetic rats (Shao et al, 2016 ). Similarly, Sampath et al ( 2016 , 2017 ) have shown maximum FBG (50%) reduction and potent aldose reductase inhibition upon intraperitoneal administration of [6]-gingerol (25 and 75 mg/kg bw) three times per week for 16 weeks to C57BL/6J hyperlipidemic mice. The oral treatment showed higher reduction of FBG relative to the study period compared to the intraperitoneal injection.…”

Section: Methodsmentioning

confidence: 80%

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

Mohammed

Islam

2018

Front. Pharmacol.

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Spices possess tremendous therapeutic potential including hypoglycemic action, attributed to their bioactive ingredients. However, there is no study that critically reviewed the hypoglycemic potency, safety and the bioavailability of the spice-derived bioactive ingredients (SDBI). Therefore, the aim of the study was to comprehensively review all published studies regarding the hypoglycemic action of SDBI with the purpose to assess whether the ingredients are potential hypoglycemic agents or adjuvant. Factors considered were concentration/dosages used, the extent of blood glucose reduction, the IC50 values, and the safety concern of the SDBI. From the results, cinnamaldehyde, curcumin, diosgenin, thymoquinone (TQ), and trigonelline were showed the most promising effects and hold future potential as hypoglycemic agents. Conclusively, future studies should focus on improving the tissue and cellular bioavailability of the promising SDBI to achieve greater potency. Additionally, clinical trials and toxicity studies are with these SDBI are warranted.

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Section: Methodsmentioning

confidence: 80%

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

Mohammed

Islam

2018

Front. Pharmacol.

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“…It has been long recognized that ginger and ginger extract have beneficial effects on glucose and lipid metabolism . Most studies have focused on the antidiabetic and anti‐obesity effects of gingerols and shogaols extracted from ginger . These compounds exert their biological activities largely by activating AMPK, an energy sensor that regulates glucose and lipid metabolism .…”

Section: Discussionmentioning

confidence: 99%

“…Most studies have focused on the antidiabetic and anti‐obesity effects of gingerols and shogaols extracted from ginger . These compounds exert their biological activities largely by activating AMPK, an energy sensor that regulates glucose and lipid metabolism . Though S6K1 plays a central role in the metabolic syndrome and type 2 diabetes, whether targeting S6K1 with natural products can improve glucose metabolism remains unexplored.…”

Section: Discussionmentioning

confidence: 99%

Gingerenone A Sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase

Chen¹,

Sun²,

Prinz

et al. 2018

Molecular Nutrition Food Res

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Scope: The bioactive constituents in ginger extract responsible for their anti-hyperglycemic effect and the underlying mechanisms are incompletely understood. Gingerenone A (Gin A) has been identified as an inhibitor of p70 S6 (S6K1), a kinase that plays a critical role in the pathogenesis of insulin resistance. Our study aims to evaluate if Gin A can sensitizes the insulin receptor by inhibiting S6K1 activity. Methods and results: Western blot analysis revealed that Gin A induced phosphatidylinositide-3 kinase (PI3K) feedback activation in murine 3T3-L1 adipocytes and rat L6 myotubes, as evidenced by increased AKTS473 and S6K1T389 but decreased S6S235/236 and insulin receptor substrate 1 (IRS-1)S1101 phosphorylation. Western blot and immunoprecipitation analysis revealed that Gin A increased insulin receptor tyrosine phosphorylation in L6 myotubes and IRS-1 binding to the PI3K in 3T3-L1 adipocytes. Confocal microscopy revealed that Gin A enhanced insulin-induced translocation of glucose transporter 4 (GLUT4) into the cell membrane in L6 cells. 2-NBDG(2-N-(Nitrobenz-2-oxa-1,3-diazol-4-yl)amino)−2-deoxyglucose) fluorescent assay revealed that Gin A enhanced insulin-stimulated glucose uptake in 3T3-L1 adipocytes and L6 myotubes. Conclusions: Gin A overcomes insulin resistance and increases glucose uptake by inhibiting S6K1 activity. Gin A or other plant-derived S6K1 inhibitors could be developed as novel anti-diabetic agents.

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“…More recently, apple pomace has also been considered as a source of bio-active polyphenols, the most characteristic of which is phloridzin [ 10 , 11 ]. As with many plant phenolic compounds, apple polyphenols are thought to reduce risk for diet-related diseases such as cardiovascular disease, obesity, cancer, or diabetes due to their antioxidant properties, among others [ 12 , 13 , 14 , 15 ]. These actions are also related to phloridzin, which has been suggested as an effective agent in adjuvant treatment of obesity and hyperglycemia, primarily due to its inhibitory effect on glucose absorption from the small intestine [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Nutritional and Health-Related Effects of a Diet Containing Apple Seed Meal in Rats: The Case of Amygdalin

et al. 2017

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Apple pomace includes seeds that are rich in protein, fiber, and oil, which can be extracted from them. However, they can also contain a significant amount of toxigenic amygdalin. We hypothesized that amygdalin is a compound that significantly reduces the nutritional and health quality of defatted apple seeds. An experiment was conducted on rats that were distributed into three groups and fed with high-fructose diets. In the control (C) and amygdalin (AMG) groups, cellulose and casein were the source of dietary fiber and protein, respectively; in the apple seed meal (ASM) group, dietary fiber and protein originated from the endosperm of apple seeds, which were previously defatted and ground. A diet fed to the ASM group also contained 0.24% of amygdalin from the meal, whereas the AMG diet was supplemented with the same amount of synthetic amygdalin. After 14 days of experimental feeding, the body weight of rats was decreased in the ASM group. When compared to the C group, apparent protein digestibility and nitrogen retention were increased in the AMG group, while both were decreased in the ASM group. In the small intestine, mucosal maltase activity was decreased in the AMG and ASM groups, whereas lactase activity was only decreased by dietary amygdalin. The caecal SCFA pool and butyrate concentration were significantly increased in the ASM group compared to the other groups. Moreover, the ASM diet increased plasma concentration of high density lipoprotein (HDL) cholesterol and plasma antioxidant capacity of water-soluble substances (ACW). It also decreased the liver content of thiobarbituric acid-reactive substances (TBARS). In contrast, dietary amygdalin did not affect these indices. Dietary supplementation with apple seed meal can exert beneficial effects on the intestinal tract, blood lipid profile and antioxidant status of rats. In most cases, these effects are not limited by the presence of amygdalin. However, the nutritional value of protein from apple seed meal is relatively low.

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Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway

Cited by 74 publications

References 39 publications

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

Gingerenone A Sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase

Nutritional and Health-Related Effects of a Diet Containing Apple Seed Meal in Rats: The Case of Amygdalin

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