Specific cancer immunotherapy adjunctive to surgery for advanced gastric cancer: A report of six long term survivors

Ishikawa, Yoshinobu; Fukushima, M; Machida, Seiro; Kakuta, Hideo; Nishikawa, Tetsu; Fukuda, Sho

doi:10.1007/bf02774155

Gastroenterol Jpn

1978

DOI: 10.1007/bf02774155

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Specific cancer immunotherapy adjunctive to surgery for advanced gastric cancer: A report of six long term survivors

Yoshinobu Ishikawa

M Fukushima

Seiro Machida

et al.

Abstract: In order to improve the results with non-curatively resected advanced gastric cancer, we have tried specific cancer immunotherapy adjunctive to surgery. In this article, six long term survivors (median 6.2 years) are reported.

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1979

1982

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Cited by 3 publications

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References 7 publications

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“…In recent years, the authors (Fukushima et al 1974;Ishikawa et al 1978) performed experimental and clinical studies on the antitumor effect of I-RNA, and Immunization and extraction of RNA. The methods of immunization and extraction of RNA were previously described in detail (Fukushima et al 1974).…”

mentioning

confidence: 99%

Experimental and clinical studies on toxicity of xenogeneic tumor-specific immune ribonucleic acid.

Fukushima

Fukuda

Machida

et al. 1979

Tohoku J. Exp. Med.

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mentioning

confidence: 99%

Experimental and clinical studies on toxicity of xenogeneic tumor-specific immune ribonucleic acid.

Fukushima

Fukuda

Machida

et al. 1979

Tohoku J. Exp. Med.

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A follow-up study on chemoimmunotherapy (5-fluorouracil and BCG) in advanced gastric cancer

Popiela

Zembala²,

Oszacki

et al. 1982

Cancer Immunol Immunother

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Two hundred and seventeen patients with advanced gastric cancer were classified according to the resectability of the tumour into two groups: I, resectable (non-radical surgery), 99 patients, and II, non-resectable carcinoma, 118 patients. Within each group patients were randomly assigned to receive 5-fluorouracil (5-FU) + BCG, 5-FU, or no further treatment (surgery only). BCG was given by scarification. A 2-year follow-up is reported. The group of patients with resectable tumours and receiving chemoimmunotherapy had a statistically significant prolongation of survival compared with the 5-FU and surgery only groups. No differences in survival were observed between these treatment modalities in patients with non-resectable tumour. These observations indicate that chemoimmunotherapy may be of benefit for a selected group of patients with gastric cancer.

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Specific immunotherapy for non-curatively resected gastric cancer

Ishikawa

Kakuta

Fukushima

et al. 1979

The Japanese Journal of Surgery

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The prognosis of patients with advanced gastric cancer treated with non-curative resection is very poor. In order to improve patient prognosis, we have tried specific immunotherapy as an adjunct to surgery since January 1968. Sixty-two patients with gastric cancer underwent non-curative resection during the period of this study. Twenty-eight of these patients were treated with specific immunotherapy after surgery, and 34 patients received no additional therapy. The five year survival rate was 35 per cent in the former group, and zero in the latter. No significant difference in the degree of tumor extension and invasion was noted between the two patient groups. We concluded that specific immunotherapy as an adjunct to non-curative resection for advanced cancer is worthy of further study.

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Specific cancer immunotherapy adjunctive to surgery for advanced gastric cancer: A report of six long term survivors

Abstract: In order to improve the results with non-curatively resected advanced gastric cancer, we have tried specific cancer immunotherapy adjunctive to surgery. In this article, six long term survivors (median 6.2 years) are reported.

Cited by 3 publications

References 7 publications

Experimental and clinical studies on toxicity of xenogeneic tumor-specific immune ribonucleic acid.

Experimental and clinical studies on toxicity of xenogeneic tumor-specific immune ribonucleic acid.

A follow-up study on chemoimmunotherapy (5-fluorouracil and BCG) in advanced gastric cancer

Specific immunotherapy for non-curatively resected gastric cancer

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