Specific cellular internalization and pH-responsive behavior of doxorubicin loaded PLGA-PEG nanoparticles targeted with anti EGFRvIII antibody

Eivazi, Neda; Rahmani, Reza; Paknejad, Maliheh

doi:10.1016/j.lfs.2020.118361

Cited by 12 publications

(9 citation statements)

References 38 publications

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“…Another group reported that PLGA NPs loaded with the chemotherapeutic drug morusin and conjugated to chlorotoxin, which is a peptide specific for particular chloride channels expressed in glioma cells, resulted in significant anti-tumor effects against two human glioblastoma cell lines in vitro [ 26 ]. Similar in vitro findings using various modified forms of PLGA NPs have been published in recent years [ 27 , 28 , 29 ], and studies investigating their use against brain tumor-bearing rodent models have also been largely encouraging [ 30 , 31 ]. There is considerable literature documenting the potential of PLGA-based nanocarrier systems to treat CNS tumors via specific surface modifications and loading contents.…”

Section: Major Polymers In Nanoparticle-based Brain Cancer Researchsupporting

confidence: 63%

Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches

et al. 2022

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Translation of novel therapies for brain cancer into clinical practice is of the utmost importance as primary brain tumors are responsible for more than 200,000 deaths worldwide each year. While many research efforts have been aimed at improving survival rates over the years, prognosis for patients with glioblastoma and other primary brain tumors remains poor. Safely delivering chemotherapeutic drugs and other anti-cancer compounds across the blood–brain barrier and directly to tumor cells is perhaps the greatest challenge in treating brain cancer. Polymeric nanoparticles (NPs) are powerful, highly tunable carrier systems that may be able to overcome those obstacles. Several studies have shown appropriately-constructed polymeric NPs cross the blood–brain barrier, increase drug bioavailability, reduce systemic toxicity, and selectively target central nervous system cancer cells. While no studies relating to their use in treating brain cancer are in clinical trials, there is mounting preclinical evidence that polymeric NPs could be beneficial for brain tumor therapy. This review includes a variety of polymeric NPs and how their associated composition, surface modifications, and method of delivery impact their capacity to improve brain tumor therapy.

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Section: Major Polymers In Nanoparticle-based Brain Cancer Researchsupporting

confidence: 63%

Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches

et al. 2022

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“…Poly lactic-co-glycolic acid (PLGA) is another FDA approved polymer used to encapsulate drugs. Pre-clinical rodent and cell line studies have suggested its efficacy for glioblastoma therapy when loaded with doxorubicin [ 80 , 81 ], bevacizumab [ 82 ], and morusin [ 83 ]. Similar studies were performed showing an efficacy against gliomas with temozolomide [ 84 , 85 ] and iguratimod [ 86 ] loaded with PLGAs.…”

Section: Pre-clinical and Current Treatmentsmentioning

confidence: 99%

Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors

et al. 2022

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Chemotherapy as an adjuvant therapy that has largely failed to significantly improve outcomes for aggressive brain tumors; some reasons include a weak blood brain barrier penetration and tumor heterogeneity. Recently, there has been interest in designing effective ways to deliver chemotherapy to the tumor. In this review, we discuss the mechanisms of focused chemotherapies that are currently under investigation. Nanoparticle delivery demonstrates both a superior permeability and retention. However, thus far, it has not demonstrated a therapeutic efficacy for brain tumors. Convection-enhanced delivery is an invasive, yet versatile method, which appears to have the greatest potential. Other vehicles, such as angiopep-2 decorated gold nanoparticles, polyamidoamine dendrimers, and lipid nanostructures have demonstrated efficacy through sustained release of focused chemotherapy and have either improved cell death or survival in humans or animal models. Finally, focused ultrasound is a safe and effective way to disrupt the blood brain barrier and augment other delivery methods. Clinical trials are currently underway to study the safety and efficacy of these methods in combination with standard of care.

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“…The synthesis of PEG-Nar was conducted based on a previous study ( Eivazi et al, 2020 ; Xiong et al, 2021 ). Briefly, 1.0 g mPEG-COOH (Mw = 2000, Macklin, China), 0.5 g naringenin (Nar, J&K Scientific, China), 1.5 g 4-dimethylamino pyridine (DMAP, Sigma-Aldrich, United States), and 3.0 g 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (EDC, Sigma-Aldrich, United States) were dissolved in 1.0 ml dimethyl sulfoxide (DMSO, Macklin, China) under sonication for 5 min.…”

Section: Methodsmentioning

confidence: 99%

Application of the pH-Responsive PCL/PEG-Nar Nanofiber Membrane in the Treatment of Osteoarthritis

Wang

Zhong

et al. 2022

Front. Bioeng. Biotechnol.

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Electrospinning technology is widely used in the field of drug delivery due to its advantages of convenience, high efficiency, and low cost. To investigate the therapeutic effect of naringenin (Nar) on osteoarthritis (OA), the pH-responsive system of the polycaprolactone/polyethylene glycol-naringenin (PCL/PEG-Nar) nanofiber membrane was designed and used as drug delivery systems (DDS) in the treatment of OA. The PEG-Nar conjugate was constructed via ester linkage between mPEG-COOH and the carboxyl group of naringenin, and the PCL/PEG-Nar nanofiber membrane was prepared by electrospinning technology. When placed in the weak acid OA microenvironment, the PCL/PEG-Nar nanofiber membrane can be cleverly “turned on” to continuously release Nar with anti-inflammatory effect to alleviate the severity of OA. In this study, the construction and the application of the pH-responsive PCL/PEG-Nar nanofiber membrane drug delivery platform would throw new light on OA treatment.

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Specific cellular internalization and pH-responsive behavior of doxorubicin loaded PLGA-PEG nanoparticles targeted with anti EGFRvIII antibody

Cited by 12 publications

References 38 publications

Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches

Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches

Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors

Application of the pH-Responsive PCL/PEG-Nar Nanofiber Membrane in the Treatment of Osteoarthritis

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