Specific chromosome markers involved with chronic T lymphocyte tumors

Genetic markers on chromosome 7.

“…Chromosome 7 abnormalities have also been detected in some patients with chronic T lymphocyte tumours, but the breaks are located in different bands. 261 The met proto-oncogene, located within the 7q31 region,56 was shown to have transforming potential in vitro when activated. 55 The transforming activity was first discoverd in a mouse NIH/3T3 cell transformation assay with DNA isolated from a MNNG treated human osteosarcoma (HOS) cell line,262 and it is therefore unlike most other proto-oncogenes, which were initially identified through viral oncogenes.…”

Chromosomal abnormalities in non‐hodgkin lymphoma with peripheral t‐cell type: Effect of HTLV‐I infection

“…Abnormalities of the long arm of chromosome 6 are commonly detected in lymphoid malignancies, especially non-Hodgkin's lymphoma (Kaneko et al, 1982), ATL (Miyamoto et al, 1984), and ALL (Third International Workshop on Chromosomes in Leukemia, 1980). However, the presence of abnormalities of chromosome 14 at band pl 1 -ql1 in both groups may not indicate an aetiologic similarity between these two groups, but rather be related to the T-cell nature of both lymphomas (Zech et al, 1986). Our findings suggest that HTLV-I does not play a specific role in chromosomal abnormalities of non-Hodgkin lymphoma with peripheral T-cell type, although it remains so far unsolved whether HTLV-I is lymphomogenicper se or not.…”

Clonal t(8;14)(p11;q31) in a case of reactive lymphoproliferation

“…T h e band 14q31 is assumed to contain an oncogene which is activated in T-cell leukemias and lymphomas with inv(l4) by juxtaposition to the T-cell receptor a chain gene (Baer et al, 1987;. T-cell leukemias and lymphomas with inv (14) usually contain additional chromosome aberrations, most often an isochromosome i(8q), which implies a break event in 8 p l l or the neighboring centromeric chromosome region (Zech et al, 1986). T h e position of the chromosomal breakpoints in our case therefore indicates that the cells with t(8;14)(pll;q31) may be of T-cell lineage.…”