Specific Coeliac Disease Antibodies and Microenteropathy

Nejad, Mohammad Rostami; Zali, Mohammad Reza

doi:10.5772/38668

Serological Diagnosis of Certain Human, Animal and Plant Diseases 2012

DOI: 10.5772/38668

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Specific Coeliac Disease Antibodies and Microenteropathy

Mohammad Rostami Nejad¹,

Mohammad Reza Zali²

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2017

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Is there a relationship between occult celiac disease and functional dyspepsia?

Fath-Elbab¹,

Fouad²,

Mohammed³

et al. 2017

Int. J. Med. Med. Sci.

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This is a study to answer the question: Is there a relationship between occult celiac disease and functional dyspepsia? The study was carried out on 400 dyspeptic patients. Upper gastrointestinal tract (GIT) endoscopy was done for all patients and those with non-functional dyspepsia were excluded from the study. Duodenal biopsies with histopathological examination according to the Marsh-Oberhuber criteria were done. Serum tissue transglutaminase IgA antibody (anti-tTG-IgA) was done for patients with histopathological findings suggestive to have celiac disease (subtotal and total villous atrophy). 172 patients with endoscopic findings explaining their dyspeptic symptoms were excluded. Only patients with functional dyspepsia were enrolled in this study (228 patients). Bloating was the most common symptom (46.5%). Normal villous pattern was found in 199 cases (87.2%). Villous atrophy was found in 29 patients, subtotal atrophy in 20 cases (8.7%) and total atrophy in 9 cases (3.9%). Age group of 14-20 years (20/29, 90.9% patients) with villous atrophy was reported to have statistically significant difference (P value =0.000). Serum anti-tTG-IgA level was measured in all cases of abnormal villous pattern. Nine patients (3.9%) were proved to have a celiac disease (total villous atrophy and high serum anti-tTG-IgA) and fourteen dyspeptic patients (6.1%) had subtotal villous atrophy with high anti-tTG-IgA level could be diagnosed as occult celiac disease. Occult celiac disease should be suspected among patients with functional dyspepsia complaining of bloating, especially in age 14 to 20. Subtotal villous atrophy and high anti-tTG-IgA could be considered as occult celiac disease.

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Is there a relationship between occult celiac disease and functional dyspepsia?

Fath-Elbab¹,

Fouad²,

Mohammed³

et al. 2017

Int. J. Med. Med. Sci.

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show abstract

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Specific Coeliac Disease Antibodies and Microenteropathy

Cited by 1 publication

References 24 publications

Is there a relationship between occult celiac disease and functional dyspepsia?

Is there a relationship between occult celiac disease and functional dyspepsia?

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