Specific Cognitive Training Normalizes Auditory Sensory Gating in Schizophrenia: A Randomized Trial

Evoked and induced oscillatory activity contributes to abnormal auditory sensory gating in schizophrenia

“…Some evidence suggests that the fidelity of the neural representations is reduced in schizophrenia (e.g., Popov et al, 2011). Consequently, evoked activity, which in effect is the resonance of this representation to the incoming stimulus input, is smaller.…”

Neuroplasticity-Based Auditory Training Via Laptop Computer Improves Cognition in Young Individuals With Recent Onset Schizophrenia

“…[9][10][11][12][13] Four other studies have investigated this form of training in schizophrenia, but methodologies and results have been inconsistent across studies. [14][15][16][17] While some of the findings have been promising, the discrepancies indicate the need for additional research.…”

Cognitive Remediation for Schizophrenia: A Review of Recent Findings

“…Thus, there is currently no clear evidence that neuroplasticity-based CR provides more benefits than traditional higher-level approaches. Only one study has directly compared these approaches by randomly assigning 39 schizophrenia patients to either 20 60-minute sessions of BrainFitness CE or 12 60-90-minute sessions of CogPack [32]. In this study, betweengroup comparisons were mixed and both treatment groups had significant improvements in cognition, but the neuroplasticity-based group had larger effect sizes for cognitive gains.…”

“…One reported significant effects, in terms of normalized magnetoencephalography (MEG) sensory gating (M50 ratio) following neuroplasticity-based CR training [32]; in a separately published re-examination of the data, the researchers found normalized alpha desynchronization mediated the effects of improved auditory gating [35]. The other study concluded there were no gains in neurocognition and no changes in electroencephalogram (EEG) measures following 40 hours of BrainFitness training [36].…”

“…The five recent studies all found that neuroplasticity-based interventions do not generalize across domains of cognition. Of the five studies we reviewed, two observed definite gains on tasks related to training exercises [30•, 31], one study reported trend-level improvements on overall cognition [29], and one study observed gains in the three areas of cognition that were assessed (immediate and delayed recall and working memory) [32]. One study assessed generalization to functional outcomes, but did not find support [30].…”