Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial

Jendricke, Patrick; Centner, Christoph; Zdzieblik, Denise; Gollhofer, Albert; König, Daniel

doi:10.3390/nu11040892

Cited by 53 publications

(105 citation statements)

References 55 publications

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“…Zdzieblik et al [11] found higher FFM in their CP supplementation group compared with controls in a men’s cohort. This has been confirmed in another recent study that shows the same positive changes in FFM of their CP supplementing group compared to their placebo group in a women’s cohort [36]. The FFM includes passive as well as active contractile tissues [10,37].…”

Section: Discussionsupporting

confidence: 55%

Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men

et al. 2019

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We aimed to determine the effects of long-term collagen peptide (CP) supplementation and resistance exercise training (RET) on body composition, strength, and muscle fiber cross-sectional area (fCSA) in recreationally active men. Fifty-seven young men were randomly and double-blinded divided into a group receiving either collagen peptides (COL, 15 g/day) or a placebo (PLA). Strength testing, bioimpedance analysis, and muscle biopsies were used prior to and after an RET intervention. Food record protocols were performed during the RET intervention. The groups trained three times a week for 12 weeks. Baseline parameters showed no differences between groups, and the external training load and dietary food intake were also similar. COL showed a significant increase in fat-free mass (FFM) compared with the placebo group (p < 0.05). Body fat mass (BFM) was unchanged in COL, whereas a significant increase in BFM was observed in PLA. Both groups showed significant increases in all strength tests, with a trend for a slightly more pronounced effect in COL. The fCSA of type II muscle fibers increased significantly in both groups without differences between the two groups. We firstly demonstrated improved body composition in healthy, recreationally active men subsequent to prolonged CP supplementation in combination with RET. As the observed increase in FFM was not reflected in differences in fCSA hypertrophy between groups, we assume enhanced passive connective tissue adaptations in COL due to CP intake.

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Section: Discussionsupporting

confidence: 55%

Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men

et al. 2019

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“…When compared to both the minimum RDAs [30] and the actual dietary protein intakes for both men and women in absolute values [33], the effective daily amounts of functional collagen peptides (2.5 to 15 g) observed in the literature [6,7,8,9,10,11,12,13,14,15,16] were found to be below the maximum level of collagen that may be incorporated in the standard American diet (Table 4).…”

Section: Resultsmentioning

confidence: 99%

“…Relative to total daily protein intakes, the effective amounts of functional collagen peptides observed in the literature (2.5 g to 15 g) were found to be below the maximum level of collagen that may be incorporated as protein substitution in diets meeting the minimum RDAs for protein [6,7,8,9,10,11,12,13,14,15,16]. In practice, the daily protein consumption in the standard American diet is above the RDA, having increased slightly over the 10-year period from 1999–2008, from 15.6% to 15.9% (100 g) in men, and from 15.2% to 15.5% (67 g) in women, relative to the total energy intake [33].…”

Section: Discussionmentioning

confidence: 99%

“…As functional foods, collagen peptides have been shown to exhibit important physiological functions with a positive impact on health. Numerous studies have shown an improvement in skin elasticity [6], the recovery of lost cartilage tissue [7], reduced activity-related joint pain [8,9], strengthened tendons and ligaments [10,11,12,13], increased lean body mass in elderly men and premenopausal women [14,15], and increased bone mineral density in postmenopausal women [16]. These studies have investigated supplementation with doses of 2.5 to 15 g of bioactive collagen peptides over periods of three to 18 months.…”

Section: Introductionmentioning

confidence: 99%

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Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance

Paul¹,

Leser

Oesser

2019

Nutrients

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The results of twenty years of research indicate that the inclusion of collagen peptides in the diet can lead to various improvements in health. According to the current protein quality evaluation method PDCAAS (Protein Digestibility-corrected Amino Acid Score), collagen protein lacks one indispensable amino acid (tryptophan) and is therefore categorized as an incomplete protein source. Collagen protein displays a low indispensable amino acid profile, yet as a functional food, collagen is a source of physiologically active peptides and conditionally indispensable amino acids that have the potential to optimize health and address physiological needs posed by aging and exercise. The objective of this study was to determine the maximum level of dietary collagen peptides that can be incorporated in the Western pattern diet while maintaining its indispensable amino acid balance. Iterative PDCAAS calculations showed that a level as high as 36% of collagen peptides can be used as protein substitution in the daily diet while ensuring indispensable amino acid requirements are met. This study suggests that the effective amounts of functional collagen peptides (2.5 to 15 g per day) observed in the literature are below the maximum level of collagen that may be incorporated in the standard American diet.

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“…However, similar intervention studies using potent and established nutritional (e.g., animal-derived protein [5]) and pharmacological (e.g., testosterone [133]) stimulators of muscle growth did not observe such marked increases in fat-free mass [134], leading some to question the findings of Zdzieblik et al [134]. More recently, Jendricke et al [135] also reported greater increases in fat-free mass and a greater decrease in fat mass following dietary collagen supplementation, supporting positive body composition changes in response to this form of supplement. In the absence of known mechanisms, it has been suggested that a reduction in adipocyte size may contribute to changes in fat mass [121], in addition to the already mentioned hypothesis of ECM adaptations contributing to fat-free mass gains.…”

Section: Skeletal Musclementioning

confidence: 96%

Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes

et al. 2020

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Dietary protein is critical for the maintenance of musculoskeletal health, whereappropriate intake (i.e., source, dose, timing) can mitigate declines in muscle and bone mass and/orfunction. Animal-derived protein is a potent anabolic source due to rapid digestion and absorptionkinetics stimulating robust increases in muscle protein synthesis and promoting bone accretion andmaintenance. However, global concerns surrounding environmental sustainability has led to anincreasing interest in plant- and collagen-derived protein as alternative or adjunct dietary sources.This is despite the lower anabolic profile of plant and collagen protein due to the inferior essentialamino acid profile (e.g., lower leucine content) and subordinate digestibility (versus animal). Thisreview evaluates the efficacy of animal-, plant- and collagen-derived proteins in isolation, and asprotein blends, for augmenting muscle and bone metabolism and health in the context of ageing,exercise and energy restriction.

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Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial

Cited by 53 publications

References 55 publications

Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men

Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men

Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance

Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes

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