Specific complications of liver resection and their prevention

Шабунин, А. В.; Парфенов, И. П.; Бедин, В. В.; Тавобилов, М. М.; Греков, Д. Н.; Дроздов, П. А.; Карпов, А. А.

doi:10.17116/hirurgia20200315

Cited by 8 publications

(1 citation statement)

References 12 publications

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“…The most effective treatment of liver cancer is surgical resection, but its initial resection rate is low ( Shabunin et al, 2020 ). For patients with primary or metastatic liver tumors that are expected to have insufficient future liver remnant (FLR), ALPPS may be considered for radical resection ( Yao et al, 2014 ; Petrowsky et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Liver Regeneration During ALPPS

Xiao

Peng

et al. 2022

Front. Cell Dev. Biol.

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Liver cancer is one of the most lethal malignant tumors in the world, and surgical resection is the main treatment for liver cancer. Liver failure due to insufficient residual liver volume is a fatal complication after hepatectomy. How to effectively increase the residual liver volume after hepatectomy and improve the safety of hepatectomy has always been a problem to be solved in liver surgery. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) effectively reduces the occurrence of liver failure due to insufficient residual liver volume after hepatectomy, thereby increasing the probability of radical resection by inducing rapid proliferation of residual liver tissue. However, the molecular mechanism of residual liver tissue regeneration after primary ALPPS (combined liver partition and portal vein ligation) remains unclear. Here, we found that lots of circular RNAs (circRNAs) are upregulated after ALPPS in pig liver cells; then, we identified the orthologous circRNA in humans and pigs to detect their function in liver regeneration. The results showed that loss of circ-0067724 and circ-0016213 could suppress liver cell proliferation. Together, these findings suggest that circ-0067724 and circ-0016213 play an important role in liver cell proliferation, and this may help us to find new strategies to promote liver regeneration.

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Section: Introductionmentioning

confidence: 99%

Mechanism of Liver Regeneration During ALPPS

Xiao

Peng

et al. 2022

Front. Cell Dev. Biol.

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Hepatocellular cancer. Current trends and the results in surgical treatment

et al. 2022

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Aim. To analyze the results of a multidisciplinary approach to the treatment of patients with hepatocellular cancer in a multidisciplinary oncology clinic.Materials and Methods. From 2007 to 2021, 259 patients with hepatocellular cancer were surgically treated in the Department of Liver and Pancreas Surgery of the city clinical hospital named after S.P. Botkin. Liver resections of different extent were performed in 74 (28.6%) patients, radiofrequency ablation – in 19 (7.3%), microwave ablation – in 20 (7.7%), hepatic artery chemoembolization with radiofrequency ablation – in 34 (13.1%), regional chemotherapy – in 104 (40.2%), liver transplantation – in 8 (3.1%) patients.Results. The overall five- and ten-year survival after liver resection was 51.4% and 31.1% respectively. The poor prognostic factors following liver resection were age >70 years (p = 0.03), postoperative complications (p = 0.04), lymph node metastases (p = 0.01), and a body mass index >30 kg/m2 (p = 0.045). Complications that developed after radiofrequency (microwave) ablation and chemoembolization of the hepatic artery with radiofrequency ablation were 5.1% and 5.8%. Within 90 days after liver resection, three (1.1%) patients died. Complications after resection developed in 18 (24.3%) cases during the same period. With metastases measuring ≤3 cm, the overall five-year survival after radiofrequency and microwave ablation was 36.8% and 35% respectively. With neoplasms measuring 3–5 cm, the best five-year survival was after hepatic artery chemoembolization and radiofrequency ablation (44.1%). The overall fiveyear survival after hepatic artery chemoembolization was 11.5%. No complications or deaths resulted from liver transplantation. With an average follow-up period of 12.5 months, none of the patients experienced disease recurrence or died.Conclusion. Using a multidisciplinary approach in a multidisciplinary oncology clinic improves the results of treating patients with hepatocellular cancer.

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Clinical case of two-stage surgical treatment large liver hemangioma

Pelts

Tropin

Pachgin³

2023

Journal of Volgograd State Medical University

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Postresection hepatic insufficiency is a formidable complication after liver resections, leading to an unfavorable course of the postoperative period and, often, to a fatal outcome. The article presents a clinical case of successful surgical treatment of tumor of the liver and prophylactics of hard remnant liver insufficiency. The article presents the results of treatment of a patient with a large liver tumor by a staged method, a review of the immediate data is given retrospectively by describing the course of diagnosis and treatment of the disease. We have illustrated a case of successful two-stage surgical treatment of a patient with a large hemangioma of the liver using laparoscopic ligation of the right branch of the portal vein, which makes it possible to prevent the development of severe post-resection liver failure.

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Specific complications of liver resection and their prevention

Cited by 8 publications

References 12 publications

Mechanism of Liver Regeneration During ALPPS

Mechanism of Liver Regeneration During ALPPS

Hepatocellular cancer. Current trends and the results in surgical treatment

Clinical case of two-stage surgical treatment large liver hemangioma

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