Specific Conditions: Diagnosis of H. pylori Infection in Case of Upper Gastrointestinal Bleeding

Choi, Yoon Jin

doi:10.1007/978-981-287-706-2_14

Cited by 5 publications

(6 citation statements)

References 42 publications

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“…Helicobacter pylori (H. pylori) infection is one of the most common chronic diseases in the world. 11 Different methods are available for investigating of H. pylori infection. 12 The present study designed to compare the serological test and stool antigen test in the diagnosis of H. pylori.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serological test in the diagnosis of Helicobacter pylori and risk factors associated with the infection

2020

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Background: Serological testing has been widely used for the diagnosis of H. pylori. This study aimed to evaluate the serological test and to determine the sensitivity and specificity of the test in the diagnosis of H. pylori. The study also aimed to address if there are risk factors like blood grouping, Smoking, Age, gender, and residence of the patients associated with H. pylori infection.Methods: A prospective cross‑sectional study was performed among 100 symptomatic patients attending Dr. Suliman dispensary, Elnehoud city in west Kordofan state-Sudan, from March to September 2016. H. pylori were detected on plasma by using Healgen immunochromatography test cards from Xiamen Boson Biotech Co., Ltd (China), and identified from a stool by using monoclonal antigen detection from the same trademarked company. Data for the risk factors associated with the infection were assessed in a participant interview.Results: The serological test showed significant differences when compared to the stool antigen test p-value = 0.000. The statistical analysis showed moderate sensitivity and high specificity of the serological test compared to the stool antigen detection test. The study also showed that smoking [odds ratio (OR): 1.20, 95% confidence interval (CI): (1.24-4.02) and blood grouping (OR: 1.10, 95% CI: (1.08-1.60) were risk factors for H. pylori infection.Conclusions: The serological test showed high specificity and moderate sensitivity in comparison to the stool antigen test. The increased risk of H. pylori infection associated with smoking and blood grouping.

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Section: Discussionmentioning

confidence: 99%

Evaluation of serological test in the diagnosis of Helicobacter pylori and risk factors associated with the infection

2020

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“…At present, the urease breath test (UBT) is considered the gold standard method of diagnosing HP infection in both pre-and post-eradicated cases [2]. There are two carbon isotopes used for UBT: 13 Cnon-radioactive and 14 C-radioactive.…”

Section: Non-invasive Methodsmentioning

confidence: 99%

“…It is the most common infectious human pathogen, infecting more than 50% of the populations worldwide (approximately 30% of children and 60% of adults), and is associated with 70% of benign gastric ulcers and 90% of duodenal ulcers [1,2]. The relative risk of gastric cancer in a HP positive group is 1.7-5.3 times higher than that in a HP negative group [3,4].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection: A recent approach to diagnosis and management

Rana¹,

Wang²,

Li³

et al. 2017

J. Biomed

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Helicobacter pylori infection is the most common infection worldwide and is associated with simple dyspepsia, heartburn and peptic ulcer diseases, most commonly leading to upper gastrointestinal bleeding and, ultimately, to the severe complication of gastric malignancy. Ninety percent of duodenal ulcers and 70% of gastric ulcers are associated with helicobacter pylori infections. Noninvasive methods, such as the urea breath test (UBT-13C or 14C) and fecal antigen test (FAT), have high sensitivity and specificity for the diagnosis of H. pylori. However, 4-6 weeks of anti-secretary drugs (proton pump inhibitor) prior to testing can lead to false negative results. Invasive methods have benefits over noninvasive methods in the case of peptic ulcer diseases by taking samples for culture to determine their sensitivities and to stage disease progression to malignant transformation. Initially, standard triple regimen was the choice for treatment worldwide. However, high antibiotic resistances in various geographical regions have recently made standard quadruple therapy (bismuth-based) the preferred treatment. Recent studies have shown the promising benefits of 10-14 days of sequential and concomitant quadruple therapies as the first line option in high drug resistance areas, in cases of multidrug resistance or in prior treatment failure cases. Levofloxacin-based triple therapy, furazolidone-based regimens, and recent hybrid or rescue therapies are also beneficial towards the eradication of H. pylori infection as a second or third line therapy. Additionally, the use of probiotics and phytomedicines improve eradication rates when used with triple or quadruple therapies.

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“…Cag A destructs the intracellular constituents of gastric epithelium via release of pro-inflammatory cytokines [4]. Attachment of H. pylori to the gastric epithelium facilitates persistence of infection, initiates colonization, release of virulence factors and the organism has the ability to protect itself from mucus , acidic PH , and peeling [5][6].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter Pylori Treatment Eradication in Egypt: Standard Clarithromycin-based Triple versus Quadruple Regimen Therapy

Afifi

Elantouny

El-Sokkary

et al. 2020

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Background and study aim: Absence of adequate treatment for Helicobacter pylori (H. pylori) infection leads to prolonged life time colonization which is responsible for complications. Antibiotics resistance is the main cause of eradication failure in H. pylori infection, thus our study aimed to evaluate the efficiency and tolerability of standard triple therapy vs. quadruple regimen therapy in H. pylori eradication in Egypt. Subjects andMethods: Our study enrolled 140 patients (65 males,75 females) who attending to Gastroenterology clinic in Internal medicine & Tropical medicine departments, Zagazig University Hospitals from (June 2018 -June 2019), aged from 20 -60 years, complained of recurrent non-specific dyspepsia and epigastric pain & proved to be positive for H. pylori stool antigen test. The patients distributed into two groups: group (1), 70 patients given Clarithromycin triple therapy [Clarithromycin 500 mg + Amoxicillin 1gm + Pantoprazole 40 mg, each twice daily]. Group (2), 70 patients given quadruple therapy [Levofloxacin 500 mg once daily + Nitazoxanide 500mg (twice daily)+ Doxycycline 100 mg (twice daily)+ Pantoprazole 40 mg (twice daily)] for 14 days. Results: H. pylori eradication rate was statistically significant higher in patients who received quadruple therapy compared to those who received Clarithromycin-based triple therapy ( 85.7% vs. 67.1 % & P = 0.001 respectively).While, statistically insignificant regarding the treatment side effects in both groups ( 11.4 % vs. 14.3 %, P= 0.33 respectively). Conclusion: Quadruple therapy is preferable to Clarithromycin-contained triple therapy in tolerability and eradication of H. pylori in Egypt.

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Specific Conditions: Diagnosis of H. pylori Infection in Case of Upper Gastrointestinal Bleeding

Cited by 5 publications

References 42 publications

Evaluation of serological test in the diagnosis of Helicobacter pylori and risk factors associated with the infection

Evaluation of serological test in the diagnosis of Helicobacter pylori and risk factors associated with the infection

Helicobacter pylori infection: A recent approach to diagnosis and management

Helicobacter Pylori Treatment Eradication in Egypt: Standard Clarithromycin-based Triple versus Quadruple Regimen Therapy

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