Specific distribution of non-phosphorylated neurofilaments characterizing each subfield in the mouse auditory cortex

Horie, Minoru; Tsukano, Hiroaki; Takebayashi, Hirohide; Shibuki, Katsuei

doi:10.1016/j.neulet.2015.08.055

Cited by 11 publications

(11 citation statements)

References 42 publications

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“…1a ). Delineation of this functional map is consistent with differences in molecular distribution 5 6 and projections from the auditory thalamus, the medial geniculate body (MGB) 5 7 8 .…”

supporting

confidence: 59%

“…The rostrocaudal distance from the bregma was determined, comparing the coronal view of the Nissl-stained slice with the corresponding slice in the Paxinos and Franklin atlas 19 . This method provides reliable standard values for the distance from the bregma in C57BL/6 mice 6 20 31 32 . We evaluated the dorsoventral level of the injection site by measuring the distance between the dorsal edge of the rhinal fissure and the line penetrating the center of the injection site on the images rotated clockwise by 15° ( Fig.…”

Section: Resultsmentioning

confidence: 99%

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Quantitative map of multiple auditory cortical regions with a stereotaxic fine-scale atlas of the mouse brain

Tsukano

Horie

Hishida

et al. 2016

Sci Rep

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Optical imaging studies have recently revealed the presence of multiple auditory cortical regions in the mouse brain. We have previously demonstrated, using flavoprotein fluorescence imaging, at least six regions in the mouse auditory cortex, including the anterior auditory field (AAF), primary auditory cortex (AI), the secondary auditory field (AII), dorsoanterior field (DA), dorsomedial field (DM), and dorsoposterior field (DP). While multiple regions in the visual cortex and somatosensory cortex have been annotated and consolidated in recent brain atlases, the multiple auditory cortical regions have not yet been presented from a coronal view. In the current study, we obtained regional coordinates of the six auditory cortical regions of the C57BL/6 mouse brain and illustrated these regions on template coronal brain slices. These results should reinforce the existing mouse brain atlases and support future studies in the auditory cortex.

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“…1a ). Delineation of this functional map is consistent with differences in molecular distribution 5 6 and projections from the auditory thalamus, the medial geniculate body (MGB) 5 7 8 .…”

supporting

confidence: 59%

Section: Resultsmentioning

confidence: 99%

Quantitative map of multiple auditory cortical regions with a stereotaxic fine-scale atlas of the mouse brain

Tsukano

Horie

Hishida

et al. 2016

Sci Rep

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“…In six cases, the sections were also processed for parvalbumin (PV) or SMI32 fluorescent immunostaining (Figure 1, B and F). Previous studies reported that PV and SMI32 immunoreactivity in the AC delineate lemniscal auditory areas (primary auditory cortex A1 and anterior auditory field AAF (Cruikshank, Killackey et al 2001, Horie, Tsukano et al 2015)). However, no studies described the distribution of layer 5 and 6 corticocollicular neurons with respect to these neurohistological markers.…”

Section: Resultsmentioning

confidence: 96%

Connectional heterogeneity in the mouse auditory corticocollicular system

Yudintsev¹

2019

Preprint

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26The auditory cortex (AC) sends long-range projections to virtually all subcortical 27 structures important for hearing. One of the largest and most complex of these -28 the projection between AC and inferior colliculus (IC, the corticocollicular 29 pathway) -has attracted attention due to its potential to alter IC response 30properties. The corticocollicular pathway comprises a component originating from 31 layer 5, but recent evidence suggests a significant contribution from deep layer 6, 32 constituting 25% of corticocollicular neurons in mouse. The functions of layer-33 specific corticocollicular projections are poorly understood. Here, using a 34 combination of tracers and in vivo imaging, we observed that layer 5 and layer 6 35 corticocollicular neurons differ in their cortical areas of origin, as well as IC 36 termination patterns. Layer 5 corticocollicular neurons are concentrated in 37 primary AC areas while layer 6 corticocollicular neurons emanate from broad 38 auditory and non-auditory areas of temporal cortex. In addition, layer 5 projects 39 to three IC subdivisions with axo-somatic terminals in the central nucleus, while 40 layer 6 projects to non-central nuclei and targets the most superficial layers. 41These findings suggest that layer 5 corticocollicular neurons form a direct 42 connection between primary AC and IC while the layer 6 projection is more 43 diffusely organized and carries non-auditory information to modulate IC. 44

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“…In contrast, our data showed a neurometabolic decoupling above 29°C in brain slice. While FAD signals were used to track the neuronal activity in vivo , where the core body temperature of the subject was kept at 37–37.5°C [33,35], our study showed an inability to detect FAD signals at 37°C. Given that the neurometabolic coupling at 25°C was associated with the maximum oxidative capacity and the maximum metabolic change evoked by the neuronal activity, 37°C, the optimal temperature in vivo could possibly be shifted to lower temperature in vitro .…”

Section: Discussionmentioning

confidence: 94%

Effect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex

Ibrahim

Wang

Lesicko

et al. 2017

Pflugers Arch - Eur J Physiol

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Tight coupling of neuronal metabolism to synaptic activity is critical to ensure that the supply of metabolic substrates meets the demands of neuronal signaling. Given the impact of temperature on metabolism, and the wide fluctuations of brain temperature observed during clinical hypothermia, we examined the effect of temperature on neurometabolic coupling. Intrinsic fluorescence signals of the oxidized form of flavin adenine dinucleotide (FAD) and the reduced form of nicotinamide adenine dinucleotide (NADH), and their ratios, were measured to assess neural metabolic state and local field potentials were recorded to measure synaptic activity in the mouse brain. Brain slice preparations were used to remove the potential impacts of blood flow. Tight coupling between metabolic signals and local field potential amplitudes was observed at a range of temperatures below 29°C. However, above 29 °C, the metabolic and synaptic signatures diverged such that FAD signals were diminished, but local field potentials retained their amplitude. It was also observed that the declines in the FAD signals seen at high temperatures (and hence the decoupling between synaptic and metabolic events), is driven by low FAD availability at high temperatures. These data suggest that neurometabolic coupling, thought to be critical for ensuring the metabolic health of the brain, may show temperature dependence, and is related to temperature-dependent changes in FAD supplies.

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Specific distribution of non-phosphorylated neurofilaments characterizing each subfield in the mouse auditory cortex

Cited by 11 publications

References 42 publications

Quantitative map of multiple auditory cortical regions with a stereotaxic fine-scale atlas of the mouse brain

Quantitative map of multiple auditory cortical regions with a stereotaxic fine-scale atlas of the mouse brain

Connectional heterogeneity in the mouse auditory corticocollicular system

Effect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex

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