SUMMARYWe document serial changes in the electrocardiogram (ECG) and myocardial markers in a case of severe heat stroke treated with cooling procedures. A 23-year-old comatose male with heat stroke was presented in the emergency room. The condition of the patient was complicated by hepatic failure, rhabdomyolysis, acute renal failure, and cardiac abnormalities. ECG revealed diffuse ST-T elevation; serum levels of myocardial markers were remarkably high and diffuse hypokinesis was observed on the echocardiogram. Cooling procedures, including applying cold vapor to the patient's skin, a gastric lavage with cold water, and an intravenous cold fluid infusion were not successful. Since multiple organ damage (heart, liver, central nervous system, and kidney) was evident, we utilized continuous hemodialysis and hemofiltration, using cold dialysate for efficient cooling. The patient recovered from the multiple organ damage and was removed from the intensive care unit 14 days after the onset. The cardiac abnormalities had normalized within several days without any damage to the myocardium. Q waves were not detected in any lead in the ECG. When interpreting ST-T elevation in the ECG of a heat stroke patient, caution should be used so as to not misdiagnose it as an acute myocardial infarction. (Int Heart J 2005; 46: 543-550) Key words: Heat stroke, Electrocardiography, Multiple organ failure, Myocardium HEAT stroke is an acute thermoregulatory failure that often results from exposure to high temperatures.1) The diagnosis of heat stroke is usually based on central nervous system dysfunction and a rectal temperature of 41°C or higher, as well as occasional multi-organ damage and dysfunction.2,3) Heat stroke can be exercise induced (exertional) or non-exercise induced (classic), and occurs when heat gain exceeds heat loss from the skin by radiation, convection, or evaporation.
4)Several cardiac complications have been documented in heat stroke cases, 5,6) and certain nonspecific ECG changes, including ST-T elevation, have been described. ST-T elevation is rare in heat stroke and is sometimes attributed to corFrom the