2009
DOI: 10.1016/j.jchromb.2008.12.062
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Specific GC–MS/MS stable-isotope dilution methodology for free 9- and 10-nitro-oleic acid in human plasma challenges previous LC–MS/MS reports

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Cited by 48 publications
(45 citation statements)
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“…Consequently, the concentrations of fatty acid nitration products in tissues and fl uids have been the subject of controversy ( 34 ). Initial concentrations of free and esterifi ed NO 2 -FA were initially reported to be in the high nM range ( 14 ).…”
Section: Discussionmentioning
confidence: 99%
“…Consequently, the concentrations of fatty acid nitration products in tissues and fl uids have been the subject of controversy ( 34 ). Initial concentrations of free and esterifi ed NO 2 -FA were initially reported to be in the high nM range ( 14 ).…”
Section: Discussionmentioning
confidence: 99%
“…The presence of the endogenously formed NO 2 -FA was reported for the first time more than a decade ago [9]. Several LC-MS/MS and gas chromatography-MS/MS studies have been directed toward quantification of LaNO 2 and OaNO 2 in human blood plasma, and reported values between 300 pmol/L [9][10][11]13] and 600 nmol/L [14,15], whereas AaNO 2 remained undetected [10]. Recently, Bonnaci et al [12] showed that dietary cLa rather than bisallylic La is a preferential substrate for the nitration by ONOO -and • NO 2 , with endogenous levels 0.3 to 1.3 nmol/L in healthy human plasma.…”
Section: No 2 -Fa In the Cardiomyocyte Nitrosative Stress Modelmentioning
confidence: 99%
“…In vivo formation of nitrated fatty acids (NO 2 -FA) was supported by their detection in human blood plasma [9][10][11][12][13], membranes of red blood cells [14], and urine [15,16]. Recent evidence indicates increased nitroalkene production rates in various inflammatory models, such as a 20-fold higher cholesteryl nitrolinoleate level in murine J774.1 macrophages activated by an inflammatory stimulus [17].…”
Section: Introductionmentioning
confidence: 99%
“…For the first time, the nonesterified nitro-oleic acid (NO 2 -OA) has been found by LC-MS/MS in human plasma, at a basal concentration of about 600 nM [5]. Recently, our group has reported on the development, validation, and application of a highly specific GC-MS/MS method for the quantification of NO 2 -OA in human plasma [13]. In order to avoid potential interferences we incorporated in this GC-MS/MS method a HPLC step for separation and isolation of NO 2 -OA.…”
Section: Introductionmentioning
confidence: 99%