Specific H+/K+-ATPase inhibitors decreased contractile responses of isolated rat vas deferens

Yenişehirli, Aydan; Onur, Rüştü

doi:10.1016/j.phrs.2006.07.005

Cited by 15 publications

(11 citation statements)

References 44 publications

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“…PPIs can also affect other cytoskeletal-mediated processes, such as neutrophil chemotaxis [21], gallbladder relaxation [22], smooth muscle activity [20], and vas deferens contractility [23] by altering intracellular calcium homeostasis [22]. Similarly, omeprazole and lansoprazole have been found to affect arterial contractions by modulating intracellular calcium [19].…”

Section: Discussionmentioning

confidence: 99%

Transmucosal Gastric Leak Induced by Proton Pump Inhibitors

et al. 2008

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Despite their remarkable safety profile and lack of clinical side effects, proton pump inhibitors (PPIs) induce a transmucosal gastric leak to non-electrolyte probes of various sizes. The ex vivo addition of PPIs to isolated rat gastric corpus increases transmucosal permeability in a dose-dependent manner, which corresponds with PPIs' dose-dependent inhibition of acid secretion. Upon the addition of omeprazole, lansoprazole, or esomeprazole, a small decrease in transepithelial resistance and the concomitant stimulation of short circuit current was observed. Additionally, transepithelial flux of (14)C-[D]-mannitol (MW 182.17) across the gastric mucosa increased by a mean of 68% immediately following the addition of 200 microM omeprazole. This flux increase was bidirectional. Omeprazole also increased the paracellular permeability to larger radiolabeled probes, including (14)C-sucrose (MW 342.3) and (14)C-polyethylene glycol (MW 4,000) by 118% and 350%, respectively. However, the flux of still larger probes, 10,000 and 70,000 MW dextrans, was not increased. Because PPIs are so widely used and are assumed to be innocuous, this transmucosal gastric leak must be further investigated, as it may carry considerable biomedical implications.

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Section: Discussionmentioning

confidence: 99%

Transmucosal Gastric Leak Induced by Proton Pump Inhibitors

et al. 2008

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“…-induced contraction effects on human artery rings 45) and rat vas deferens. 46) Therefore, the inhibitory effects of PPIs on calcium channels may be responsible for PPI-induced negative inotropic effects. Additionally, ouabain could increase intracellular Ca 2+ , while PPIs are able to induce a further increased intracellular Ca 2+ level after ouabain addition.…”

Section: Ppis and Arrhythmiasmentioning

confidence: 99%

Potential Cardiovascular Risks of Proton Pump Inhibitors in the General Population

Zhu

Hong

2017

Int. Heart J.

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SummaryProton pump inhibitors (PPIs) are the most effective gastric acid-suppressing agents and the mainstay medical therapy for a series of acid peptic diseases. In general, the safety profile of PPIs is excellent. However, with long-term drug administration, the safety and potency of PPIs has been questioned. In the cardiovascular field, drug-drug interactions related to PPIs have been identified with particular attention regarding the use of PPIs combined with clopidogrel in patients with acute coronary syndrome. Currently, cardiovascular risks from PPIs may extend from patients with coronary artery disease to the general population. This review summarizes the possible cardiovascular risks in PPI users with no history of cardiovascular diseases and discusses possible biological mechanisms. (Int Heart J 2017; 58: 163-166)

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“…It has been suggested that transient lower oesophageal relaxation and nocturnal acid breakthrough during PPI treatment are the underlying mechanisms of refractory GORD [16] . There is some evidence that PPIs may induce relaxation of smooth‐muscle preparations, including guinea pig gallbladder, [4] human myometrial smooth muscle, [9] human internal mammary and radial arteries in vitro , [17] rat aorta, [18] rabbit corpus cavernosum, [7] rabbit prostatic strips [6] and rat vas deferens [8] . However, the mechanism of PPI‐induced relaxation of smooth muscles remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Although the underlying causes of GORD are not yet known, transient relaxation of the LOS is believed to be the primary mechanism. [1] It has been reported that PPI induces relaxation in different types of smooth muscle preparations, for instance guinea-pig gallbladder, [4] guinea-pig and human airway smooth muscles, [5] rabbit prostatic strips, [6] rat corpus cavernosum, [7] rat vas deferens [8] and human myometrial smooth muscle. [9] However, effects of PPI have yet to be investigated on the reactivity of LOS, the disfunction of which may cause GORD where PPI are frequently prescribed.…”

Section: Introductionmentioning

confidence: 99%