SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN D<sub>3</sub>IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS: PRESENCE IN MONOCYTES AND INDUCTION IN T LYMPHOCYTES FOLLOWING ACTIVATION

Bhalla, A. K.; Amento, Edward P.; Clemens, Thomas L.; Holick, Michael F.; Krane, Stephen M.

doi:10.1210/jcem-57-6-1308

Cited by 573 publications

(298 citation statements)

References 10 publications

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“…During the 1980s vitamin D receptors were identified on cells of the immune system (53,54) sparking interest in immunemodulating effects of vitamin D. For IBD, there is a compelling body of evidence from animal models that vitamin D has the capacity to alter immune responses (11,(55)(56)(57) . Vitamin D deficiency, for example, accelerates the development of experimental colitis in IL-10 knock-out mice, (12) whereas treatment with dietary vitamin D and calcium appear to protect against the development of inflammation (58) .…”

Section: Vitamin D Status and Associations With Disease Severity In Cmentioning

confidence: 99%

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn?

O’Sullivan

2014

Proc. Nutr. Soc.

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There is increasing scientific interest in the field of vitamin D research, moving the focus beyond bone health to other disease processes. Low circulating vitamin D levels have been reported as a risk factor for several pathophysiologically divergent diseases, including cancers, diabetes, CVD, multiple sclerosis and inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease (IBD). But, therein, remains the challenge: can any single nutrient contribute to multiple complex disease mechanisms and, ultimately, have therapeutic potential? The aim of this review is to critically evaluate several strands of scientific evidence surrounding vitamin D and inflammation, primarily focusing on IBD. Epidemiological studies suggest an increased incidence of IBD and rheumatoid arthritis in countries of more northern latitudes, mirroring sunlight patterns. A considerable body of evidence supports the anti-inflammatory effects of vitamin D, at least in animal models of IBD. Although it is accepted that suboptimal vitamin D status is common in IBD, some studies suggest that this associates with more severe disease. With regard to treatment, the data are only beginning to emerge from randomised controlled trials to suggest that people with IBD may remain in remission longer when treated with oral vitamin D. In conclusion, several strands of evidence suggest that vitamin D may modify the immune response in IBD. There is a continued need for large well-designed clinical trials and mechanistic studies to determine if, and how, this emerging promise translates into tangible clinical benefits for people with chronic debilitating diseases such as IBD.

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Section: Vitamin D Status and Associations With Disease Severity In Cmentioning

confidence: 99%

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn?

O’Sullivan

2014

Proc. Nutr. Soc.

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“…The identification of the vitamin D receptor (VDR) in peripheral blood mononuclear cells sparked the early interest in vitamin D as an immune system regulator (Bhalla et al 1983;Provvedini et al 1983). All cells of the immune system that have been evaluated express the VDR and at least in T cells activation induces the expression of additional VDR (Veldman et al 2000;Mahon et al 2003).…”

Section: Vitamin D and The Immune Systemmentioning

confidence: 99%

The paradoxical effects of vitamin D on type 1 mediated immunity

Cantorna

Bruce

2008

Molecular Aspects of Medicine

122

115

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Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease. 1,25(OH) 2 D 3 treatments have been shown to suppress Th1 mediated immunity and protect animals from experimental autoimmunity. Th1 mediated immunity is important for clearance of a number of different infectious diseases. For tuberculosis 1,25(OH) 2 D 3 treatment is associated with decreased Th1 mediated immunity but increased bactericidal activity. Systemic candidiasis is unaffected by 1,25(OH) 2 D 3 treatment. The seemingly paradoxical effects of 1,25(OH) 2 D 3 and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system. The interplay of these vitamin D targets and their impact on the host-immune response then dictate the outcome.

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“…Vitamin D receptors (VDRs) have been identified on cells of the extra-skeletal system, especially those of the immune system, including human leukocytes, activated T cells and monocytes (7,8) . VDRs have also been identified on respiratory epithelium and bronchial smooth muscle cells.…”

Section: Introductionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents

Menon

Maranda²,

Nwosu³

2012

Journal of Pediatric Endocrinology and Metabolism

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Background: There is no consensus on the association between vitamin D and asthma. Objective: To determine the relationship between 25-hydroxyvitamin D [25(OH)D] levels and asthma symptom severity in children and adolescents. Methods: A retrospective, case-control study of 263 subjects of ages 2 -19 years with asthma who were compared to 284 non-asthmatic controls of similar ages. Subjects were excluded if they had diseases of calcium or vitamin D metabolism or were receiving calcium or vitamin D supplementation. Serum 25(OH)D was measured in all subjects. Asthma symptom severity, usually stratified into 6 steps, was stratified into five steps [1 -5] based on the number and dose of controller medications used as outlined by the National Heart, Lung, and Blood Institute ' s guidelines. Mean 25(OH)D values were compared between the asthmatic patients and controls, as well as among the five steps of asthma symptom severity. Results were adjusted for age, sex, BMI, race and severity of asthma symptoms. Results: There was no difference in 25(OH)D between asthmatic patients and controls (28.64 ± 10.09 vs. 28.42 ± 11.47, p = 1.0). However, there was a significant difference in 25(OH)D between obese and non-obese asthmatic patients (23.33 ± 7.67 vs. 30.16 ± 10.20, p < 0.0001), as well as obese and non-obese controls (24.56 ± 9.90 vs. 29.50 ± 11.66, p = 0.003). Mean 25(OH)D levels did not vary significantly among the five steps of asthma symptom severity. Conclusions: There were no differences in mean 25(OH) D levels between asthmatic patients and controls. Mean 25(OH)D level was significantly lower in both the obese asthmatic patients and obese controls. Asthma severity had no relationship to mean 25(OH)D levels.

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SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN D₃IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS: PRESENCE IN MONOCYTES AND INDUCTION IN T LYMPHOCYTES FOLLOWING ACTIVATION

Cited by 573 publications

References 10 publications

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn?

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn?

The paradoxical effects of vitamin D on type 1 mediated immunity

Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents

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SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN D3IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS: PRESENCE IN MONOCYTES AND INDUCTION IN T LYMPHOCYTES FOLLOWING ACTIVATION

Cited by 573 publications

References 10 publications

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn?

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn?

The paradoxical effects of vitamin D on type 1 mediated immunity

Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents

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Product

Resources

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SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN D₃IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS: PRESENCE IN MONOCYTES AND INDUCTION IN T LYMPHOCYTES FOLLOWING ACTIVATION