Specific IgE level and prediction of tolerance in mustard allergy*1

Rancé, F.; Micheau, Philippe; Janka, Dora; Abbal, M.; Söderström, Lars

doi:10.1016/j.jaci.2003.12.527

Cited by 2 publications

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“…The Brassica seed storage proteins napin and cruciferin, two of the most abundant proteins in the seed, have been identified as the most likely candidates for triggering allergies, with key epitopes identified in their sequences [ 15 , 32 – 35 ], however evidence shows other seed proteins present in other species outside the Brassica family, namely 7S globulin type vicilins, and oil-body proteins like oleosins and non-specific lipid transfer proteins may also elicit an allergenic response [ 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Shotgun proteomics of Brassica rapa seed proteins identifies vicilin as a major seed storage protein in the mature seed

et al. 2021

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Proteins make up a large percentage of the Brassica seed and are second only to the oil in economic importance with uses for both animal and human nutrition. The most abundant proteins reported in the seeds of Brassica are the seed storage proteins cruciferin and napin, belonging to the 12S globulin and 2S albumin families of proteins, respectively. To gain insight into the Brassica rapa seed proteome and to confirm the presence and relative quantity of proteins encoded by candidate seed storage genes in the mature seed, shotgun proteomics was carried out on protein extracts from seeds of B. rapa inbred line R-o-18. Following liquid chromatography tandem mass spectrometry, a total of 34016 spectra were mapped to 323 proteins, where 233 proteins were identified in 3 out of 4 biological replicates by at least 2 unique peptides. 2S albumin like napin seed storage proteins (SSPs), 11/12S globulin like cruciferin SSPs and 7S globulin like vicilin SSPs were identified in the samples, along with other notable proteins including oil body proteins, namely ten oleosins and two oil body-associated proteins. The identification of vicilin like proteins in the mature B. rapa seed represents the first account of these proteins in the Brassicaceae and analysis indicates high conservation of sequence motifs to other 7S vicilin-like allergenic proteins as well as conservation of major allergenic epitopes in the proteins. This study enriches our existing knowledge on rapeseed seed proteins and provides a robust foundation and rational basis for plant bioengineering of seed storage proteins.

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Section: Introductionmentioning

confidence: 99%

Shotgun proteomics of Brassica rapa seed proteins identifies vicilin as a major seed storage protein in the mature seed

et al. 2021

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“…The enzymes inside the mustard don't break down much in the digestive tract, and the allergen is present even if the mustard is cooked in food. The major allergen in brown mustard is Bra J 1 [17].…”

Section: Various Food Allergy Interactions With Immunoglobulinmentioning

confidence: 99%

Effect of Food Allergy among Patients Affected by Delta and Omicron Variants-A Case Study

2022

JCEI

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Background: The variants of SARS-CoV-2 have been affecting people globally since 2020. The Delta variant, mainly in India and the omicron variant in multiple countries since Nov 2021, has infected millions of people; many died out of them. Amongst all factors, food allergy is one factor that also accelerates many infected people’s comorbidities and overall health status during the pandemic. Aims: The study aimed to assess the role of some common food allergies in Delta and Omicron infected people in the Indian population. Methods: The study was designed with 50 covid positive home-isolated patients (out of 62) infected by both the mentioned variants from April 2021 until 15th January 2022. However, they were not severely ill but had comorbidities such as diabetes, obesity, hepatomegaly, etc. After the negative test result, each participant was requested to attend a telephonic interview for 15 minutes. Further, they were offered free online diet consultation considering the fatigue and some allergic symptoms. ATLAS-Ti-9 software was used for the fundamental analysis. Results: Based on their self-referred serological allergy test (SAT), we found that 23 samples of milk (46%), 14 (28%) samples of citrus fruits, 12 (24%) patients were allergic due to mustard oil and other detections too based on the positive interpretation (+ to +++) of specific IgE (IU/ml). The patients were facing type-1 hypersensitivity but no other severe allergic issues. Conclusions: Food allergy accelerated respiratory syndromes and comorbidities, mainly among the infected (Delta and Omicron) patients who could also have a high chance of hypersensitivity due to some common ingesting allergens.

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Specific IgE level and prediction of tolerance in mustard allergy*1

Cited by 2 publications

References 0 publications

Shotgun proteomics of Brassica rapa seed proteins identifies vicilin as a major seed storage protein in the mature seed

Shotgun proteomics of Brassica rapa seed proteins identifies vicilin as a major seed storage protein in the mature seed

Effect of Food Allergy among Patients Affected by Delta and Omicron Variants-A Case Study

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