Specific infiltration pattern of FOXP3+ regulatory T cells in chronic histiocytic intervillositis of unknown etiology

Capuani, C.; Meggetto, Fabienne; Duga, I.; Danjoux, Marie; March, Michael; Parant, Olivier; Brousset, Pierre; Aziza, Jacqueline

doi:10.1016/j.placenta.2012.12.004

Cited by 34 publications

(16 citation statements)

References 37 publications

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“…www.nature.com/scientificreports/ www.nature.com/scientificreports/ Our results are consistent with previous reports of the perinatal outcomes of CIUE that analysed relatively few cases (range: 6-69 cases) [1][2][3][9][10][11][12][13][14][15]17,24 . The overall incidence of live births was 30-81%, among which 31-88% were premature and 63-83% showed FGR 9,10,14,17,24 . Marchaudon et al 11 reported severe FGR (less than the third percentile) in 61.5% of 69 cases of CIUE, which is in accordance with our rate of 63.4%.…”

Section: Discussionsupporting

confidence: 91%

“…Our results are consistent with previous reports of the perinatal outcomes of CIUE that analysed relatively few cases (range: 6–69 cases) 1 – 3 , 9 – 15 , 17 , 24 . The overall incidence of live births was 30–81%, among which 31–88% were premature and 63–83% showed FGR 9 , 10 , 14 , 17 , 24 . Marchaudon et al .…”

Section: Discussionmentioning

confidence: 99%

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Adverse perinatal outcomes of chronic intervillositis of unknown etiology: an observational retrospective study of 122 cases

Mattuizzi

Sauvestre

André

et al. 2020

Sci Rep

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our study aimed to assess perinatal outcomes and recurrence rate of chronic intervillositis of Unknown etiology (ciUe). We conducted an observational retrospective study in a tertiary care university hospital in France from January 1, 1997 to July 31, 2018. 122 pregnancies (102 women) with CIUE were included. Cases of the Department of Histopathology placenta database were re-analysed independently by three pathologists specializing in fetal pathology. Diagnosis of CIUE was confirmed according to: (1) the presence of cellular infiltrate in the intervillous space, (2) ~ 80% of the mononuclear cells in the intervillous space positive for CD68, (3) infiltration occupying at least 5% of the intervillous space, and (4) no clinical or histopathological sign of infection. Outcomes of pregnancies with CIUE (miscarriages, stillbirths, terminations of pregnancy, live birth with or without prematurity or fetal growth restriction) and proportion of ciUe recurrence were analysed. the lost pregnancies comprised 17 (13.9%) miscarriages, 17 (13.9%) stillbirths, and 18 (14.8%) terminations of pregnancy. Of the 70 (57.4%) pregnancies that led to a live birth, 38 (54.3%) new-borns were premature and 50 (72.5%) exhibited fetal growth restriction. Among the 102 women, 23 subsequently became pregnant, half of whom (n = 11) developed recurrent CIUE. CIUE was associated with high rates of adverse perinatal outcomes, including pregnancy loss, fetal growth restriction, and preterm birth with a risk of recurrence nearly 50%. Abbreviations aPL Antiphospholipid AZA Azathioprine BMI Body mass index CIUE Chronic intervillositis of unknown etiology HCQ Hydroxychloroquine HES Hematoxylin-eosin-saffron FGR Fetal growth restriction LDA Low-dose aspirin LMWH Low-molecular-weight heparin TOP Termination of pregnancy MVM Maternal vascular malperfusion of the placental bed PIg Polyvalent immunoglobulin

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Adverse perinatal outcomes of chronic intervillositis of unknown etiology: an observational retrospective study of 122 cases

Mattuizzi

Sauvestre

André

et al. 2020

Sci Rep

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“…Chronic intervillositis of unknown etiology is a strongly associated with miscarriage, intrauterine fetal demise and a very high risk of recurrence (141,(153)(154)(155). Women with a history of recurrent CIUE have gone on to successful live birth after treatment with aspirin and low molecular weight heparin (LMWH), aspirin and corticosteroids, aspirin, LMWH, and steroids, or aspirin, prednisone, LMWH and hydroxychloroquine (147,156,157).…”

Section: Pregnancy Lossmentioning

confidence: 99%

Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease

et al. 2020

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“…5,6 Importantly, CHI has a 25%-100% chance of recurrence in subsequent pregnancies, 3,6,9 with more severe or diffuse CHI associated with poorer outcomes. 10 When infiltration of mononuclear cells and fibrin deposition have been graded in CHI cases, 11 placentas with the lowest score corresponded to live births and those with highest grade have a 73% chance of in utero loss. A 2013 retrospective study from the Netherlands also correlated increased CHI severity with a shorter pregnancy duration and increased risk of miscarriage, stillbirth and neonatal death.…”

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confidence: 99%

Chronic histiocytic intervillositis: A breakdown in immune tolerance comparable to allograft rejection?

Brady

Williams

Sharps

et al. 2020

American J Rep Immunol

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From implantation of the embryo through to birth, successful pregnancy relies upon the promotion of a tolerogenic uterine environment to allow the foetus to thrive. 1 Simultaneously, and of equal importance, the maternal inflammatory response must be conserved to protect the mother and foetus against pathogens. 2 This "paradox" of pregnancy, first described by Sir Peter Medawar in the 1950s, 1 has prompted investigation into the immunology of pregnancy, particularly where it may be dysfunctional. Chronic histiocytic intervillositis (CHI), also known as chronic intervillositis (CI), chronic intervillositis of unknown aetiology

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Specific infiltration pattern of FOXP3+ regulatory T cells in chronic histiocytic intervillositis of unknown etiology

Cited by 34 publications

References 37 publications

Adverse perinatal outcomes of chronic intervillositis of unknown etiology: an observational retrospective study of 122 cases

Adverse perinatal outcomes of chronic intervillositis of unknown etiology: an observational retrospective study of 122 cases

Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease

Chronic histiocytic intervillositis: A breakdown in immune tolerance comparable to allograft rejection?

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