Specific local nasal immunotherapy: Single center experience on 324 patients

Scarpa, Alfonso; Luca, Pietro De; Marra, Pasquale; Bisogno, A.; Salzano, Giovanni; Ricciardiello, Filippo; Capasso, Pasquale; Romano, Domenico; Viola, Pasquale; Ralli, Massimo; Stadio, Arianna Di; Salzano, Francesco Antonio

doi:10.1016/j.amjoto.2022.103694

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…was achieved, based on the observation of the decrease in the use of control medications for signs and symptoms and mainly by the improvement in the patients' quality of life, without adverse effects. In another study, Sacarpa A et al, 2023, used LNIT for patients with allergic rhinitis (allergy to mites, to Graminaceae or Parietaria pollen) from Salerno, Italy [113]. It was shown that LNIT is a valid alternative to the most used local routes of AIT (subcutaneous and sublingual administration).…”

Section: Biodistribution Of Radiolabeled Allergen In Lnit (Nasal)mentioning

confidence: 99%

Allergen Specific Immunotherapy (AIT)

Thiago Luiz Bandeira,

Isabela Mansur Bandeira,

Juliana CM Vasconcellos

et al. 2023

World J. Adv. Res. Rev.

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Allergic/atopic patients do not develop immune tolerance to certain substances in the environment which are harmless to non-allergic individuals. These patients are hypersensitive to these substances-allergens. Specific Allergen Immunotherapy (AIT), also known as Allergy Shots or Desensitization, is a therapeutic approach used to treat allergic conditions, such as allergic rhinitis, allergic asthma, and insect sting allergies. The primary goal of AIT is to reduce the allergic response to specific allergens by gradually exposing the patient to increasing doses of the allergen over time. This exposure helps the immune system build tolerance to the allergen, leading to a decrease in allergic symptoms and a long-term improvement in clinical outcomes. Research has confirmed the long-term clinical efficacy of AIT, and its ability to induce antigen-specific tolerance. In this review, we aim to discuss the immunological mechanisms involved in different types of AITs, their efficacy and safety.

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Section: Biodistribution Of Radiolabeled Allergen In Lnit (Nasal)mentioning

confidence: 99%

Allergen Specific Immunotherapy (AIT)

Thiago Luiz Bandeira,

Isabela Mansur Bandeira,

Juliana CM Vasconcellos

et al. 2023

World J. Adv. Res. Rev.

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Local allergic rhinitis: the issue and its significance

Rozenson¹

2023

General Physician

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The article presents the pathogenetic mechanisms of allergic rhinitis and approaches to the allergic diagnosis of this pathology. The clinician has an opportunity to verify the presence of this particular form of rhinitis when using the following laboratory diagnostic methods: determining the level of IgE in the nasal secretion, using the basophil activation test, rhinocytogram, and other nasal cytology tests. The basophil activation test is a functional study in which flow cytometry is used to determine the expression of activation markers on basophils following the exposure to the relevant al lergen. The use of this test in diagnostics showed that it had 50% sensitivity and 93% specificity in the examination of patients with suspected sensitization to house dust allergens. Even higher sensitivity rates (66%) with equal specificity (91.7%) were found in patients with sensitization to pollen allergens.

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Specific local nasal immunotherapy: Single center experience on 324 patients

Cited by 2 publications

References 13 publications

Allergen Specific Immunotherapy (AIT)

Allergen Specific Immunotherapy (AIT)

Local allergic rhinitis: the issue and its significance

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