Specific Lyt 123 cells are involved in protection against Listeria monocytogenes and in delayed-type hypersensitivity to listerial antigens.

Abstract

Specific anti-Lyt antisera and complement were used to determine the Lyt phenotype of peritoneal exudate T lymphocytes from Listeria monocytogenes-immune mice. It was found that Lyt 123+ T cells are crucially involved both in protection against listerial infection and in delayed-type hypersensitivity (DTH) to listerial antigens. Thus, both functions critically depend on a T-cell subclass phenotypically different from that which mediates DTH to noninfectious antigens and help in antibody formation on the one hand, as well as those T cells mediating cytotoxic reactions on the other.

Implications of the Inability of Listeria monocytogenes EGD-e To Grow Anaerobically Due to a Deletion in the Class III NrdD Ribonucleotide Reductase for Its Use as a Model Laboratory Strain

“…by H. Hahn (Berlin). In the Berlin laboratory it was routinely propagated through mice (30). Other listerial species and strains used in this study are shown in Table 1.…”

Inhibition of mitogen-induced lymphokine production by Cyclosporin A

“…It is therefore possible that CS-A can induce regulatory T-cells directly to produce one type of immunity and to suppress another. Accumulating evidence suggests that DTH involves primarily helper T-lymphocytes [14][15][16]. Blockade of DTH could thus be attributed to the selective action of CS-A on helper T-cells.…”

Immunology of Mycobacterial Infections

“…During these studies, both tuberculin hypersensitivity and antituberculous immunity can be transferred to naive recipients using distinctive subsets of T cells differing in their Lyt-alloantigenic makeup (Orme and Collins, 1984;Kaufmann et al, 1979). For unknown reasons, antituberculous immunity can be demonstrated in the lungs of adoptively immunized mice only with great difficulty, compared to that in the spleen (Lefford, 1975b).…”