Specific Multiomic Profiling in Aortic Stenosis in Bicuspid Aortic Valve Disease
Borja Antequera-González,
Neus Martínez-Micaelo,
Carlos Sureda-Barbosa
et al.
Abstract:Introduction and purpose: Bicuspid aortic valve (BAV) disease is associated with faster aortic valve degeneration and a high incidence of aortic stenosis (AS). In this study, we aimed to identify differences in the pathophysiology of AS between BAV and tricuspid aortic valve (TAV) patients in a multiomics study integrating metabolomics and transcriptomics as well as clinical data. Methods: Eighteen patients underwent aortic valve replacement due to severe aortic stenosis: 8 of them had a TAV, while 10 of them … Show more
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