Specific, non-invasive and magnetically-directed targeting of magnetic erythrocytes in blood vessels of mice

Cai, Qingchun; Mai, Xiaoli; Miao, W.; Zhou, Xin; Zhang, Yu; Liu, Xuan; Lü, Wei; Zhang, Jianqiong; Gu, Ning; Sun, Jianfei

doi:10.1109/tbme.2019.2958683

Cited by 4 publications

(6 citation statements)

References 34 publications

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“…As illustrated in Figure A, a cone‐shaped magnet, as previously described, was employed to generate a focused magnetic field. [ 23 ] Simulation results for magnetic flux density and magnetic field (Figure 4B; Figure S8, Supporting Information) revealed a maximal magnetic intensity of approximately 0.5 T at the tip of the magnet, where the magnetic flux lines converged into this point with a maximal gradient of 150 T/ m. For magnetic targeting, mice receiving the foot‐pad injections of Ag‐MLs were placed on the magnetic platform immediately after vaccine administration (Figure 4A,C). The tip of the cone‐shaped magnet was placed against the popliteal fossa of the mouse, making close contact with the skin (Figure 4A,C).…”

Section: Resultsmentioning

confidence: 99%

Magnetic Delivery of Antigen‐Loaded Magnetic Liposomes for Active Lymph Node Targeting and Enhanced Anti‐Tumor Immunity

Sheng,

Liu,

Ding

et al. 2023

Adv Healthcare Materials

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Therapeutic cancer vaccines offer the greatest advantage of enhancing antigen‐specific immunity against tumors, particularly for immunogenic tumors, such as melanoma. However, clinical responses remain unsatisfactory, primarily due to inadequate T cell priming and the development of acquired immune tolerance. A major obstacle lies in the inefficient uptake of antigen by peripheral dendritic cells (DCs) and their migration to lymph nodes for antigen presentation. In this context, we propose the magnetic delivery of antigen‐loaded magnetic liposomes (Ag‐MLs) to actively target lymph node. These magnetic responsive liposomes contain soluble mouse melanoma lysate and iron oxide nanoparticles in the core, along with the immunostimulatory adjuvant CpG‐1826 incorporated into the lipid bilayer. When applied through magnetic targeting in the mouse melanoma model, Ag‐MLs accumulate significantly in the target lymph nodes. This accumulation results in increased population of active DCs in lymph nodes and cytotoxic T lymphocytes (CTLs) within tumors, correlating with effective tumor growth inhibition. Overall, our study demonstrates the potential of magnetic targeting as an effective strategy for delivering cancer vaccines and activating the immune response, offering a novel platform for cancer immunotherapies.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Magnetic Delivery of Antigen‐Loaded Magnetic Liposomes for Active Lymph Node Targeting and Enhanced Anti‐Tumor Immunity

Sheng,

Liu,

Ding

et al. 2023

Adv Healthcare Materials

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“…In most state-of-the-art publications [17,25,28,[30][31][32]46,47,102,103,105,106,108], the particle distribution is only evaluated for a fixed distance between the magnetic field source and the vessel. However, in this paper, we have shown that the distance between the magnetic field source and vessels has a significant impact on particle steering (compare Figure 12).…”

Section: Comparison With the State-of-the-art Researchmentioning

confidence: 99%

“…Overall, in this paper, we conclude that, for the evaluation of particle steering, the particle distribution or the distribution based on ferrofluid concentrations must be evaluated. When measurements are conducted, camera images are often taken and used to extract the particle distribution, for example by using gray-scale images of the tube [16,32,36,99,104,106] or fluorescence [42,54,103,106]. In other publications, the particles are collected at the end of the tubes, and the particle concentration is determined from these samples [17,42,99].…”

Section: Comparison With the State-of-the-art Researchmentioning

confidence: 99%

How the Magnetization Angle of a Linear Halbach Array Influences Particle Steering in Magnetic Drug Targeting—A Systematic Evaluation and Optimization

Thalmayer,

Götz,

Fischer

2024

Symmetry

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The main challenge in magnetic drug targeting lies in steering the magnetic particles, especially in deeper body layers. For this purpose, linear Halbach arrays are currently in focus. However, to the best of the authors’ knowledge, the impact of the magnetization angle between two neighboring magnets in Halbach arrays has not been investigated for particle steering so far. Therefore, in this paper, a systematic numerical parameter study of varying the magnetization angle of linear Halbach arrays is conducted. This is completed by undertaking a typical magnetic drug targeting scenario, where magnetic particles have to be steered in an optimized manner. This includes the calculation of the magnetic flux density, its gradient, the total magnetic energy, and the resulting magnetic force based on a fitting function for the different Halbach constellations in the context of examining their potential for predicting the particle distribution. In general, increased magnetization angles result in an increased effective range of the magnetic force. However, as there is a trade-off between a weak force on the weak side of the array and a simple manufacturing process, a magnetization angle of 90∘ is recommended. For evaluating the steering performance, a numerical or experimental evaluation of the particle distribution is mandatory.

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“…Under the guidance of an external magnetic field, therapeuticsloading MNPs [1,171] and magnetic assemblies, such as microbubbles [4], microspheres [177], liposomes [152,178], and aerosols [179] can be delivered more selectively to the target site with a lower systemic distribution of the cytotoxic drug. Even for some somatic and germ cells, like platelets [151], erythrocytes [180], and sperms [5], combining with magnetic materials can also be controlled by magnetic field as promising nanocarriers. Biomimetic drug carries derived from human endogenous cells have advantages of higher biosafety, targeting abilities, and somatic cell-fusion abilities than artificial carriers.…”

Section: Magnetomechanical Propertymentioning

confidence: 99%

“…Biomimetic drug carries derived from human endogenous cells have advantages of higher biosafety, targeting abilities, and somatic cell-fusion abilities than artificial carriers. Recently, our group has discovered that a focused magnetic field could direct the aggregation of magnetic erythrocytes into a specific region for quick modeling of vascular diseases [180]. Though many studies have proved the effectiveness of external magnetic field on the drug delivery, for deep tissues in body, a deeply-buried magnet might be more preferable to guide the MNPs [171].…”

Section: Magnetomechanical Propertymentioning

confidence: 99%

Adaptive iron-based magnetic nanomaterials of high performance for biomedical applications

Zhang

2021

Nano Res.

Self Cite

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With unique physicochemical properties and biological effects, magnetic nanomaterials (MNMs) play a crucial role in the biomedical field. In particular, magnetic iron oxide nanoparticles (MIONPs) are approved by the United States Food and Drug Administration (FDA) for clinical applications at present due to their low toxicity, biocompatibility, and biodegradability. Despite the unarguable effectiveness, massive space for improving such materials' performance still needs to be filled. Recently, many efforts have been devoted to improving the preparation methods based on the materials' biosafety. Besides, researchers have successfully regulated the performance of magnetic nanoparticles (MNPs) by changing their sizes, morphologies, compositions; or by aggregating as-synthesized MNPs in an orderly arrangement to meet various clinical requirements. The rise of cloud computing and artificial intelligence techniques provides novel ways for fast material characterization, automated data analysis, and mechanism demonstration. In this review, we summarized the studies that focused on the preparation routes and performance regulations of high-quality MNPs, and their special properties applied in biomedical detection, diagnosis, and treatment. At the same time, the future development of MNMs was also discussed.

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Specific, non-invasive and magnetically-directed targeting of magnetic erythrocytes in blood vessels of mice

Cited by 4 publications

References 34 publications

Magnetic Delivery of Antigen‐Loaded Magnetic Liposomes for Active Lymph Node Targeting and Enhanced Anti‐Tumor Immunity

Magnetic Delivery of Antigen‐Loaded Magnetic Liposomes for Active Lymph Node Targeting and Enhanced Anti‐Tumor Immunity

How the Magnetization Angle of a Linear Halbach Array Influences Particle Steering in Magnetic Drug Targeting—A Systematic Evaluation and Optimization

Adaptive iron-based magnetic nanomaterials of high performance for biomedical applications

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