Specific panic attack symptoms in panic disorder patients with putative genetic factor

Nishimura, Yukika; Tanii, Hisashi; Hara, Naomi; Inoue, Ken; Nishida, Atsushi; Okada, Motohiro; Kaiya, Hisanobu; Okazaki, Yuji

doi:10.1111/j.1440-1819.2008.01917.x

Cited by 1 publication

(1 citation statement)

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“…reported that "Paresthesia," could be good indicator of severe panic attacks [42]. According to Nishimura et al , panic disorder patients with first-degree familial history (FH) are significantly younger at onset, show more symptoms, and have more frequent attacks with paresthesias and chills or hot flashes at first panic attack compared to patients without first degree FH [43]. We think that EEG abnormalities in panic disorder patients might have some relation to physiological predispositions that easily cause panic attacks.…”

Section: Discussionmentioning

confidence: 99%

EEG abnormalities in panic disorder patients: a study of symptom characteristics and pathology

Hayashi

Makino

Hashizume

et al. 2010

BioPsychoSocial Med

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BackgroundSince the 1980s, a high EEG abnormality rate has been reported for patients with panic disorder. However, how the EEG abnormalities of panic disorder patients are related to the clinical features and pathology of these patients has yet to be clarified. In this study we investigated whether or not EEG abnormalities are related to the 13 symptoms in the DSM-IV criteria for a diagnosis of panic attacks.MethodsSubjects were 70 patients diagnosed with panic disorder.Logistic regression analysis was performed with EEG findings as dependent variables and age, sex and with or without the 13 symptoms as independent variables.Results(1)EEG findings for panic disorder patients with EEG abnormalities: Of the 17 patients, 13 had repeated slow waves in the θ-band; the most prevalent EEG abnormality found in this study. Paroxysmal abnormality interpreted as epileptiform was found in only two cases. (2)Nausea or abdominal distress (37.7% vs 82.45%, OR-12.5), derealization or depersonalization (7.5% vs 47.1%, OR = 13.9,) and paresthesias (43.4% vs 64.7%, OR = 7.9,) were extracted by multivariate analysis as factors related to EEG abnormalities.ConclusionOf the 70 patients studied, 17 had EEG abnormalities. Among these 17 cases, "repeated slow waves in the θ-band" was the most common abnormality. The factors identified as being related to EEG abnormalities are nausea or abdominal distress, derealization or depersonalization, and paresthesias. The study indicated that physiological predispositions are closely related to panic attacks.

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Section: Discussionmentioning

confidence: 99%