Specific parameters of the thromboelastographic profile of patients with COVID-19 in the intensive care unit

261,435,768 COVID-19 infections were detected worldwide, of them 5,207,634 deaths were registered. Identifying markers of the patient severity early in the course of the disease can facilitate the assessment of the risk of adverse outcome.The objective: To compare values of laboratory parameters and their changes during treatment of patients with a complicated course of COVID-19 infection.Subjects and Methods. 56 patients were included in the study, all of them were hospitalized to COVID Hospital of the Clinic of Bashkir State Medical University, Russian Ministry of Health, from September 30, 2021 to November 15, 2021, and their complicated course of the disease necessitated transfer to the intensive care unit (ICU). The laboratory evaluation included the following: a general blood and urine counts, blood chemistry including urea and creatinine, liver transaminases, and blood coagulogram (prothrombin time (PTT), prothrombin index (PTI), thrombin time, fibrinogen, and blood clotting time).Results. In the group of patients with a fatal outcome on the day of transfer to ICU, lymphocytopenia, eosinopenia, elevated values of creatinine, total bilirubin, transaminases, C-reactive protein, D-dimer, and ferritin were noted. Also on this day, microscopic hematuria, proteinuria and cylindruria were detected in the urine tests of most patients in this group during treatment.Conclusion. Critical deviations in the results of hematological and biochemical tests were revealed. Particular attention should be paid to such parameters as the level of erythrocytes, lymphocytes, eosinophils, glucose, urea, creatinine, total bilirubin, aspartate aminotransferase, alanine aminotransferase, creatine kinase, C-reactive protein, D-dimer, and ferritin.

show abstract

Early Changes in Clinical and Laboratory Parameters in Patients Died of COVID-19

Bakhtiyarova

Papoyan

Алексеев

et al. 2022

Vestn. anesteziol. reanimatol.

View full text Add to dashboard Cite

show abstract

The influence of prolonged high-adsorption membrane hemofiltration on the hemostatic system in patients with COVID-19

Akmalova¹,

Polushin²,

Соколов³

et al. 2023

Vestn. anesteziol. reanimatol.

View full text Add to dashboard Cite

The objective was to evaluate the effects of prolonged (24–72 h) high-adsorption membrane hemofiltration on the hemostatic system.Materials and methods. A retrospective study included 91 patients with COVID-19 who received prolonged high-adsorption membrane hemofiltration (Prismaflex system) as part of complex therapy. The group was divided into two subgroups, taking into account the outcome of the disease. We analyzed the level of D-dimer, fibrinogen, platelet count, percentage of large platelets, thromboelastogram indicators, reflecting external and internal coagulation pathways (Intem, Extem) before and after the procedure. The levels of serine proteases (tPA, PAI) were additionally analyzed in 35 cases.Results. An increase in the D-dimer level, accompanied by a decrease in the fibrinogen concentration, was detected after sorption, which was especially noticeable in patients with unfavorable outcome (by 2.8 times). The thromboelastogram parameters after the procedure did not go beyond the normal range, the level of tPA and PAI became lower in both subgroups but there was no connection with the outcome.Conclusion. Prolonged high-adsorption membrane hemofiltration in COVID-19 patients does not have a negative influence on hemostasis system. A decrease in fibrinogen level after the procedure is associated with its mechanical removal from the circulation because of fibrin adhesion on the filter’s membrane and on sets’ walls; an increase in the D-dimer level should not be associated with the detection of degradation of fibrin networks.

show abstract

Anticoagulation Activity of 6-Methyluracil Hydrazone Derivatives Including a Four-Member Sulfur-Containing Cycle With Different Degree of Sulfur Atom Oxidation

A.S.

S.A.

Абзалилов

et al. 2021

Mediko-farmacevtičeskij žurnal "Pulʹs"

View full text Add to dashboard Cite

Aim: Data on the chemical structure of biologically active compounds show that various antibacterial, antiviral, antitumor, anticoagulant, and other agents contain heterocyclic systems. However, at this stage in the development of medicine and pharmacy, thrombosis and thromboembolic complications remain one of the key causes of morbidity and mortality on a global scale. Therefore, the search for new anticoagulants is an urgent trend in pharmaceutical chemistry and pharmacy in general. Purpose: The purpose of our experiment was to synthesize new biologically active compounds and screen the obtained substances for anticoagulant activity. Materials and Methods: The synthesis of new compounds was carried out according to the methods developed by us. The structure of the obtained biologically active substances was confirmed by 1H NMR spectroscopy. The individuality of the compounds was monitored by TLC. Preliminary in silico screening of the synthesized substances was performed on the Way2Drag platform. Experimental data on anticoagulant activity were recorded in vitro on the blood of healthy male donors aged 18-24 years. For screening, solutions of substances were selected that did not sediment within 2 hours of settling at room temperature after dissolution. In addition to control indicators for the studied solutions, data were recorded when the isovolumic volume of the solvent was added to exclude its effect on the hemostatic system. The data obtained were processed using the statistical package Statistica 10.0 (StatSoft Inc, USA). The normal distribution of the actual data was checked using the Shapiro-Wilk test. Conclusions: Methods for the synthesis of new compounds based on 6-methyluracil have been developed. Screening of the anticoagulant activity of the obtained substances was carried out. New potential anticoagulants have been identified.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Specific parameters of the thromboelastographic profile of patients with COVID-19 in the intensive care unit

Cited by 3 publications

References 15 publications

Early Changes in Clinical and Laboratory Parameters in Patients Died of COVID-19

Early Changes in Clinical and Laboratory Parameters in Patients Died of COVID-19

The influence of prolonged high-adsorption membrane hemofiltration on the hemostatic system in patients with COVID-19

Anticoagulation Activity of 6-Methyluracil Hydrazone Derivatives Including a Four-Member Sulfur-Containing Cycle With Different Degree of Sulfur Atom Oxidation

Contact Info

Product

Resources

About