Specific pH effect for selective colorimetric assay of glutathione using anti-aggregation of label-free gold nanoparticles

Li, Jianfang; Huang, Pengcheng; Wu, Fang

doi:10.1039/c7ra00399d

Cited by 14 publications

(7 citation statements)

References 49 publications

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“…GSH ( l -γ-glutamyl- l -cysteinyl-glycine) is the most abundant intracellular nonprotein thiol. 24 Because GSH has different vital multitasking functions within our body like maintaining immunity, detoxification of peroxides and free radicals (antioxidant property), and regulations of protein function and cell growth; therefore, imbalance of GSH within our body can cause serious health hazards like cellular damage, liver damage, and even cancer. 25 Keeping these in mind, we have herein reported a simple colorimetric assay to detect and quantify the amount of GSH present.…”

Section: Introductionmentioning

confidence: 99%

“…Besides the dual effect of diverse morphology of mesoporous carbon and catalytic features of Au, Au/OMC shows a very good peroxidase-like activity which is further utilized for the detection of glutathione (GSH). GSH ( l -γ-glutamyl- l -cysteinyl-glycine) is the most abundant intracellular nonprotein thiol . Because GSH has different vital multitasking functions within our body like maintaining immunity, detoxification of peroxides and free radicals (antioxidant property), and regulations of protein function and cell growth; therefore, imbalance of GSH within our body can cause serious health hazards like cellular damage, liver damage, and even cancer .…”

Section: Introductionmentioning

confidence: 99%

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One Step Synthesis of a Gold/Ordered Mesoporous Carbon Composite Using a Hard Template Method for Electrocatalytic Oxidation of Methanol and Colorimetric Determination of Glutathione

et al. 2019

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Ordered mesoporous carbon-supported gold nanoparticles (Au/OMC) have been fabricated in one step through a hard template method using gold nanoparticle-intercalated mesoporous silica (GMS) to explore two different catalytic properties, for example, electrocatalytic oxidation of methanol and colorimetric determination of glutathione (GSH). The catalytically inert but conducting nature of mesoporous carbon (OMC) and promising catalytic activity of gold nanoparticles (AuNPs) has inspired us to synthesize Au/OMC. The as-prepared Au/OMC catalyst was characterized by powder X-ray diffraction, N2 adsorption–desorption, scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray analysis-elemental mapping, and X-ray photoelectron spectroscopy. The characterization results indicate that AuNPs are uniformly distributed on the surface of OMC. The conducting-OMC framework with a high surface area of Au/OMC provides superior transport of electrons through the porous surface of carbon matrix and resulted in its high efficiency and stability as an electrocatalyst for the oxidation of methanol in comparison to CMK-3, SBA-15, and GMS in alkaline medium. The efficiency of Au/OMC toward methanol oxidation in alkaline medium is much higher in comparison to that in acidic medium. The lower value of If/Ib in the acidic medium in comparison to that in the alkaline medium clearly indicates that the oxidation process with Au/OMC as a catalyst is much more superior in alkaline medium with better tolerance toward the accumulation of intermediate CO species on the active surface area. Furthermore, the Au/OMC catalyst is successfully utilized for the detection and quantification of GSH spectrophotometrically with a limit of detection value of 0.604 nM.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

One Step Synthesis of a Gold/Ordered Mesoporous Carbon Composite Using a Hard Template Method for Electrocatalytic Oxidation of Methanol and Colorimetric Determination of Glutathione

et al. 2019

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“…30 The possibilities of the potential deposition of a sub-monolayer of Ag on the lateral gold nanorods in our case of S3 and S4 specimens were ruled out since the pH of the solution during the synthesis was 6, and thus the possibility of the reduction of Ag + to Ag 0 by ascorbic acid was not possible. 31 Ratiometric absorption-based gold nanosensors 32,33 have been developed by earlier researchers for the sensing and quantication of pH. In our case, it was found that a small change in pH led to the agglomeration of GNs, resulting in a corresponding change in the UV-Vis absorption spectra and color of the specimens under visible light illumination.…”

Section: Resultsmentioning

confidence: 71%

Gold nanostructures for the sensing of pH using a smartphone

et al. 2019

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“…Zhong et al, 2010 and Wu et al, 2017 research groups demonstrated the anti-aggregationenabled colorimetric assay of GSH using CI-Au NPs (particle size = 13 nm; conc. = 5/2.5 nM) with sodium piperazinebisdithiocarbamate (ppzdtc; 1.5 µM), cysteine (Cys; 4 µM), and 2-Mercapto-1-methylimidazole (MMI; 2 µM) as aggregation-inducing agents [78][79][80]. Initially, the aggregation-inducing agents functionalized on the surface of NPs reduced the electrostatic repulsion between NPs, which resulted in aggregation with a color change from red to blue.…”

Section: Au Nps-based Colorimetric Quantification Of Bio-analytes Via...mentioning

confidence: 99%

Review on Anti-Aggregation-Enabled Colorimetric Sensing Applications of Gold and Silver Nanoparticles

Shellaiah

Sun

2022

Chemosensors

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Gold- and silver nanoparticles (Au NPs and Ag NPs)-based colorimetric detection of specific analytes has attracted intense research interest and is still in great demand. The majority of Au NPs- and Ag NPs-based sensory reports have revealed that, during the analyte recognition, dispersed NPs typically aggregated and displayed color changes from wine-red to blue/purple and yellow to orange/brown, respectively. On the other hand, only a few reports demonstrated that the aggregated Au NPs and Ag NPs underwent anti-aggregation in the presence of certain analytes, which displayed reversed color changes from blue/purple to wine-red and orange/brown to yellow, correspondingly. There are some examples of anti-aggregation phenomena mentioned in a vast number of studies on Au NPs- and Ag NPs-based colorimetric sensors via NP aggregation. However, a review targeting the anti-aggregation-enabled Au NPs- and Ag NPs-based colorimetric sensing of diverse analytes is not yet available. In this review, anti-aggregation-facilitated Au NPs- and Ag NPs-based colorimetric detection of metal ions, anions, bio-analytes, pesticides, and herbicides is delivered with detailed underlying mechanisms. Moreover, the probe design, sensory requirement, merits, limitations, and future scope of anti-aggregation-enabled Au NPs- and Ag NPs-based colorimetric sensors are discussed.

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Specific pH effect for selective colorimetric assay of glutathione using anti-aggregation of label-free gold nanoparticles

Abstract: An operationally simple colorimetric method for measuring glutathione (GSH) concentration was developed using anti-aggregation of gold nanoparticles (AuNPs) in this work.

Cited by 14 publications

References 49 publications

One Step Synthesis of a Gold/Ordered Mesoporous Carbon Composite Using a Hard Template Method for Electrocatalytic Oxidation of Methanol and Colorimetric Determination of Glutathione

One Step Synthesis of a Gold/Ordered Mesoporous Carbon Composite Using a Hard Template Method for Electrocatalytic Oxidation of Methanol and Colorimetric Determination of Glutathione

Gold nanostructures for the sensing of pH using a smartphone

Review on Anti-Aggregation-Enabled Colorimetric Sensing Applications of Gold and Silver Nanoparticles

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