Specific proactive and generic reactive inhibition

Kenemans, J. Leon

doi:10.1016/j.neubiorev.2015.06.011

Cited by 82 publications

(91 citation statements)

References 89 publications

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“…For this latter kind of paradigm, Kenemans (2015), reviewing ERP findings, observed that there is little sign of right frontal ERP signature of successful vs. failed stop. While our results here mainly concern a right frontal time-frequency signature, it would be important to validate, in future studies or analyses, that this does also apply in the case of a visual-go/auditory-stop paradigm.…”

Section: Discussionmentioning

confidence: 99%

“…There have been many studies of the neural correlates of action stopping, specifically for the stop signal (and related) tasks, across species, and using many methods, see reviews by (Aron, et al, 2016a; Chambers, et al, 2009; Jahanshahi, et al, 2015; Kenemans, 2015; Schall and Godlove, 2012; Schmidt and Berke, 2017). Here we focus on the cortical aspect.…”

Section: Introductionmentioning

confidence: 99%

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Establishing a Right Frontal Beta Signature for Stopping Action in Scalp EEG: Implications for Testing Inhibitory Control in Other Task Contexts

Wagner

Wessel

Ghahremani

et al. 2018

Journal of Cognitive Neuroscience

100

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Many studies have examined the rapid stopping of action as a proxy of human self-control. Several methods have shown that a critical focus for stopping is the right inferior frontal cortex (rIFC). Moreover, electrocorticography (ECoG) studies have shown beta band power increases in the rIFC and in the basal ganglia for successful vs. failed stop trials, before the time of stopping elapses, perhaps underpinning a prefrontal-basal-ganglia network for inhibitory control. Here we tested whether the same signature might be visible in scalp EEG – which would open important avenues for using this signature in studies of the recruitment and timing of prefrontal inhibitory control. We used Independent Component Analysis and time-frequency approaches to analyze EEG from three different cohorts of healthy young volunteers (48 participants total) performing versions of the standard stop signal task. We identified a spectral power increase in the band 13–20Hz that occurs after the stop signal, but before the time of stopping elapses, with a right frontal topography in the EEG. This right frontal beta band increase was significantly larger for successful compared to failed stops in two of the three studies. We also tested the hypothesis that unexpected events recruit the same frontal system for stopping. Indeed, we show that the stopping-related right lateralized frontal beta signature was also active after unexpected events (and we accordingly provide data and scripts for the method). These results validate a right frontal beta signature in the EEG as a temporally precise and functionally significant neural marker of the response inhibition process.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Establishing a Right Frontal Beta Signature for Stopping Action in Scalp EEG: Implications for Testing Inhibitory Control in Other Task Contexts

Wagner

Wessel

Ghahremani

et al. 2018

Journal of Cognitive Neuroscience

100

View full text Add to dashboard Cite

show abstract

“…It is possible to derive the speed of stopping, known as stop signal reaction time (SSRT). Much research across species has focused on the neural correlates of going and stopping (reviewed recently by Bari and Robbins, 2013; Jahanshahi et al, 2015; Kenemans, 2015; Schall and Godlove, 2012; Zavala et al, 2015). Stopping can be done in different ways, but when done quickly and reactively (as in the standard paradigm), the underlying brain system includes the right inferior frontal cortex (rIFC), the pre-SMA, and STN of the basal ganglia, with downstream effects on pallidum, thalamus and primary motor cortex (FIGURE 3A).…”

Section: The Brain’s Network For Global Motor Stoppingmentioning

confidence: 99%

“…The scalp EEG signatures of stopping are well-established (reviewed by Kenemans, 2015). For ERPs, successful stopping is indexed by a fronto-central P3 wave (Kok et al, 2004), whereas in time-frequency space, it corresponds to a increased power of oscillations in the delta- (2–4 Hz) and low-theta (5–8Hz) frequency bands (Huster et al, 2013).…”

Section: The Brain’s Network For Global Motor Stoppingmentioning

confidence: 99%

On the Globality of Motor Suppression: Unexpected Events and Their Influence on Behavior and Cognition

Wessel

Aron

2017

Neuron

385

382

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SUMMARY Unexpected events are part of everyday experience. They come in several varieties – action errors, unexpected action outcomes, and unexpected perceptual events – and they lead to motor slowing and cognitive distraction. While different varieties of unexpected events have been studied largely independently, and many different mechanisms are thought to explain their effects on action and cognition, we suggest a unifying theory. We propose that unexpected events recruit a fronto-basal-ganglia network for stopping. This network includes specific prefrontal cortical nodes and is posited to project to the subthalamic nucleus, with a putative global suppressive effect on basal-ganglia output. We argue that unexpected events interrupt action and impact cognition, partly at least, by recruiting this global suppressive network. This provides a common mechanistic basis for different types of unexpected events, links the literatures on motor inhibition, performance-monitoring, attention, and working memory, and is relevant for understanding clinical symptoms of distractibility and mental inflexibility.

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“…Many studies have investigated the neural substrates of behavioral inhibition by using laboratory tasks that require stopping a planned action [6–10]. Under such conditions, rapid suppression of activity can be observed at various levels of the motor pathway, likely reflecting a pause in motor output [11, 12].…”

Section: Multiple Forms Of Motor Inhibition During Human Behaviormentioning

confidence: 99%

Physiological Markers of Motor Inhibition during Human Behavior

Duqué

Greenhouse

Labruna

et al. 2017

Trends in Neurosciences

231

228

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Transcranial magnetic stimulation (TMS) studies in humans have shown that many behaviors engage processes that suppress excitability within the corticospinal tract. Inhibition of the motor output pathway has been extensively studied in the context of action stopping, where a planned movement needs to be abruptly aborted. Recent TMS work has also revealed markers of motor inhibition during the preparation of movement. Here, we review the evidence for motor inhibition during action stopping and action preparation, focusing on studies that have used TMS to monitor changes in the excitability of the corticospinal pathway. We discuss how these physiological results have motivated theoretical models of how the brain selects actions, regulates movement initiation and execution, and switches from one state to another.

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Specific proactive and generic reactive inhibition

Cited by 82 publications

References 89 publications

Establishing a Right Frontal Beta Signature for Stopping Action in Scalp EEG: Implications for Testing Inhibitory Control in Other Task Contexts

Establishing a Right Frontal Beta Signature for Stopping Action in Scalp EEG: Implications for Testing Inhibitory Control in Other Task Contexts

On the Globality of Motor Suppression: Unexpected Events and Their Influence on Behavior and Cognition

Physiological Markers of Motor Inhibition during Human Behavior

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