Specific progesterone receptors in rabbit gingiva

Vittek, J.; Gordon, Gary G.; Rappaport, Sydney C.; Munnangi, P.R.; Southren, A. Louis

doi:10.1111/j.1600-0765.1982.tb01186.x

Cited by 30 publications

(32 citation statements)

References 13 publications

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“…For example, progesterone is known to lead to the development of localised inflammation. (13,14) A higher incidence of periodontitis has been seen in pregnant women than in those who were not pregnant; this incidence was found to progressively increase from the first trimester through to the third. (7,15) A probable reason for this increase could be due to the increased predisposition of periodontal tissues with increasing hormonal levels towards the end of the third trimester.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of oral lesions and measurement of salivary pH in the different trimesters of pregnancy

Jain¹,

Kaur²

2015

smedj

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INTRODUCTIONMany epidemiological studies on the prevalence of oral lesions and dental health status of pregnant women have been conducted worldwide.(1-6) However, data on the prevalence of oral lesions in the different trimesters of pregnancy is scarce. Investigations that have been done in the different trimesters are mainly restricted to dental health status and not many factors have been studied. Therefore, this study was undertaken to assess the prevalence of oral lesions during the different trimesters of pregnancy and their correlation with salivary pH change, and comparing the results against those in nonpregnant women. We also attempted to assess the changes to oral hygiene, caries, gingival and periodontal health statuses, and salivary pH in the different trimesters of pregnancy. METHODSThe study group comprised a total of 120 pregnant women (40 in the first trimester, 40 in the second, and 40 in the third) between 18 and 35 years old who attended the outpatient clinic of the Obstetrics and Gynaecology department of MM Medical Hospital, India. The control group comprised 40 nonpregnant women in a corresponding age group. The following are the exclusion criteria used in the present study: (a) contributory medical history of pathological conditions and history of drug therapy that may cause oral mucosal lesions and changes in salivary pH; and (b) smoking/ tobacco chewing habit. Data pertaining to education level and general awareness of oral hygiene were collected. The participants were from nearby villages, and most of them had dropped out of school with only a primary education. The following indices were used to assess participants' gingival and periodontal health statuses, and determine the number of teeth that were decayed, missing or filled: (a) gingival index (GI); (7) (b) simplified oral hygiene index (OHI-S); (8) (c) community periodontal index (CPI); (9) and (d) decayed-missing-filled teeth index.(10) Participants were clinically examined for the following parameters: oral hygiene, gingival health, periodontal health, dental caries, and the presence of any gingival or oral mucosal lesions (or any other oral lesions). Saliva samples were collected for the measurement of salivary pH using a digital pH meter (LT-23; Labtronics, Panchkula, Haryana, India). Saliva samples were collected from each participant at least one hour after breakfast, which would yield unstimulated saliva. For the collection of these samples, all participants were requested to be as quiet as possible. They were instructed to allow the saliva to flow into the mouth as normally as possible and expectorate into the large test tubes provided. In all, 8-10 mL of sample was collected for each participant. The pH of each sample was determined within the first half an hour after collection.The data obtained was systematically tabulated and subjected to statistical analysis. Statistical correlations among all the parameters within the first, second and third trimester groups and the control group were determined using Pearson's coeffi...

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Section: Discussionmentioning

confidence: 99%

Prevalence of oral lesions and measurement of salivary pH in the different trimesters of pregnancy

Jain¹,

Kaur²

2015

smedj

View full text Add to dashboard Cite

show abstract

“…Porém, alguns estudos ressaltam a influência dos contraceptivos orais nos níveis de citocinas e prostaglandinas diretamente relacionadas à destruição periodontal e à reabsorção óssea como a IL-1, o TNF e a PGE 2 (Elattar, 1976;Honig, Rordorf-Adam et al, 1989;Fujihashi, Kono et al, 1993;Lapp, Thomas et al, 1995;Morishita, Miyagi et al, 1999;Delima, Karatzas et al, 2002;Guncu, Tozum et al, 2005;Lapp e Lapp, 2005), influenciando ainda na produção de enzimas proteolíticas e de MMPs (Elattar, 1976;Lapp, Thomas et al, 1995;Lapp e Lapp, 2005), já que existem controvérsias quanto a ausência de receptores do estrogênio e progesterona no tecido periodontal (Vittek, Gordon et al, 1982;Vittek, Hernandez et al, 1982;Vittek, Munnangi et al, 1982). Além disso, o aumento na prevalência de microorganismos como a Prevotella intermedia (Kornman e Loesche, 1980;Jensen, Liljemark et al, 1981;Machtei, Mahler et al, 2004) durante o uso deste medicamento, nos permite sugerir que a resposta inflamatória de mulheres que fazem uso de contraceptivos orais pode se encontrar alterada (Knight e Wade, 1974;Sooriyamoorthy e Gower, 1989;Lapp, Thomas et al, 1995;Lapp e Lapp, 2005), tornando essas mulheres mais susceptíveis ao desenvolvimento e progressão da doença periodontal (Amar e Chung, 1994).…”

Section: Discussionunclassified

“…Além destas ações, o estrógeno e a progesterona exercem efeito direto sobre o periodonto, visto que a presença de receptores para os mesmos na gengiva foi demonstrada por Vittek et al (Vittek, Hernandez et al, 1982;Vittek, Munnangi et al, 1982), sugerindo que este tecido é órgão-alvo para os mesmos. Além disso, parecem existir receptores para esses hormônios também em fibroblastos periostais, da lâmina própria gengival e do ligamento periodontal e em osteoblastos (Eriksen, Colvard et al, 1988;Komm, Terpening et al, 1988).…”

Section: Ação Dos Hormônios Sexuais Sobre Os Tecidos Periodontaisunclassified

“…Portanto, estudos (Wenk, Hernandez et al, 1981;Vittek, Gordon et al, 1982;Vittek, Hernandez et al, 1982;Vittek, Munnangi et al, 1982;Parkar, Newman et al, 1996) já foram desenvolvidos com o intuito de demonstrar a presença destes receptores nos tecidos periodontais e assim confirmar ou não a influência destes hormônios nos tecidos em questão.…”

Section: Ação Dos Hormônios Sexuais Sobre Os Tecidos Periodontaisunclassified

“…Vittek et al (Vittek, Hernandez et al, 1982) Em contrapartida, estudos mais recentes (Forabosco, Criscuolo et al, 1992;Ojanotko-Harri, Forssell et al, 1992) desenvolvidos com métodos de análise mais precisos, como a técnica de reação em cadeia da polimerase (PCR), sugeriram que os resultados obtidos pelo método autoradiográfico em estudos prévios (Aufdemorte e Sheridan, 1981;Wenk, Hernandez et al, 1981;Vittek, Gordon et al, 1982;Vittek, Hernandez et al, 1982;1985), eram questionáveis, como foi demonstrado por Parkar, Newman e Olsen (Parkar, Newman et al, 1996) Loe, 1964) e profundidade de sondagem em seis sítios de cada dente presente (Ramfjord, 1959;. O escore para cada dente foi expresso quantitativamente pela soma dos escores e divisão pelo número de dentes.…”

Section: Ação Dos Hormônios Sexuais Sobre Os Tecidos Periodontaisunclassified

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