Specific Pruritic Diseases of Pregnancy

Roger, Denis; Vaillant, L.; Fignon, A; Pierre, Fabrice H.F.; Bacq, Yannick; Bréchot, Jean-François; Grangeponte, M. C.; Lorette, G

doi:10.1001/archderm.1994.01690060064006

Cited by 137 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As many as 1 in 5 women experience pruritus in pregnancy (causes include dermatological diseases, primary biliary cirrhosis, hepatitis and gall stones) of whom a small proportion have OC (5). Although OC is reasonably well researched, there is little published data on pregnant women who present with pruritus at sites suggestive of OC, but have normal LFTs and BAs.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy outcomes of women with pruritus, normal bile salts and liver enzymes: a case control study

Yoong¹,

Memtsa²,

Pun³

et al. 2008

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Pregnancy outcomes of women with pruritus, normal bile salts and liver enzymes: a case control study

Yoong¹,

Memtsa²,

Pun³

et al. 2008

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…Herpes gestationis (HG) or pemphigoid gestationis is a rare immunobullous disease occurring in Ϸ 1 in 50 000 pregnancies. 1,6,[9][10][11] HG is related to pregnancy and the puerperium and often initially becomes symptomatic in the second trimester of pregnancy with earlier relapses in subsequent pregnancies. 12 At the onset, prior to the eruption, pruritus is a constant and prominent feature.…”

Section: Introductionmentioning

confidence: 99%

Polymorphic eruption of pregnancy and herpes gestationis: comparison of granulated cell proteins in tissue and serum

Borrego

Peterson

Diez

et al. 1999

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

Polymorphic eruption of pregnancy (PEP) and herpes gestationis (HG) are pregnancy-related dermatoses of unknown aetiology with eosinophil infiltration which, at early stages, may show similar clinical and histopathological features. To determine the relative contributions of eosinophils, neutrophils and mast cells to the pathogenesis of PEP and HG through deposition of granule proteins, we studied tissue and serum from 15 patients with PEP and 10 with HG. Using indirect immunofluorescence with antibodies to human eosinophil granule major basic protein (MBP), eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), neutrophil elastase and mast cell tryptase, we determined and compared cellular and extracellular staining patterns in lesional skin biopsy specimens and, using immunoassay, measured MBP, EDN, and ECP in patients' sera. Eosinophil infiltration and extracellular protein deposition of all three eosinophil granule proteins were present in both PEP and HG indicating a pathogenic role for eosinophils in both diseases. Staining for eosinophil granule proteins was especially prominent in urticarial lesions and around blisters in HG. EDN and ECP serum levels in PEP and ECP serum levels in HG were significantly increased compared with those in normal pregnant and normal nonpregnant serum. Neutrophils were more prominent in HG specimens than in PEP specimens; extracellular neutrophil elastase was minimally present and similar in both diseases. Mast cell numbers and extracellular tryptase deposition did not differ between the two diseases and did not differ from mast cell counts in skin of normal pregnant women. This study shows that eosinophil granule proteins are deposited extracellularly in tissue and are increased in serum in both PEP and HG. Moreover, eosinophil involvement in the two diseases is more consistent than neutrophil and mast cell involvement. Comparatively, tissue eosinophil infiltration and extracellular protein deposition is more extensive in HG than in PEP, suggesting that eosinophil involvement is greater in the pathogenesis of HG than PEP and similar to that found in bullous pemphigoid.

show abstract

“…3 Most western reports quote a low incidence of around 2%. 5,6 The incidence of PUPP was 7.5%. Most of the patients were Primigravida who presented in the third trimester mostly after 28 weeks of gestation.…”

Section: Discussionmentioning

confidence: 99%

“…Winton et al and Roger et al reported incidence of Pruritus in 17% and 18% respectively of all pregnancies. 5,6 Prurigo of Pregnancy was the commonest specific disorder of pregnancy accounting for 22.5% cases. Most patients presented with excoriated lesions suggestive of Prurigo in the upper and lower extremities in second and third trimester.…”

Section: Discussionmentioning

confidence: 99%

Dermatological Diseases During Pregnancy

Chaudhary¹,

Thomas²,

Williams³

2014

jemds

View full text Add to dashboard Cite

BACKGROUND: Physiological skin changes are common during pregnancy in addition to cutaneous disease specific to pregnancy. Dermatoses specific to pregnancy are important to recognize because they are intensely pruritic or painful to mother and may pose significant risk to patients, her fetus or both. AIM: To study the dermatological diseases in pregnancy. SETTINGS & DESIGN: Study was undertaken on pregnant women who visited the dermatology OPD of the Christian medical college and Hospital, Ludhiana. MATERIAL AND METHODS: Screening for cutaneous disorders was undertaken in two hundred pregnant women attending the dermatology OPD in Christian medical college and hospital. STATISTICAL ANALYSIS USED: Was done by using SPSS version. RESULTS: Pruritus was present in 61.5% patients. Specific pregnancy dermatoses were seen in 33% and included prurigo gestationis, pruritic urticarial papules and plaques of pregnancy (PUPP) and pruritus gravidarum. Sexually transmitted diseases accounted for 10.5%; condyloma accuminatum was the commonest STD. Commonest dermatological disorder observed was eczema with 10.5% of cases. CONCLUSION: Pregnant women are prone to suffer from a wide range of dermatological and sexually transmitted diseases. Some of these are distressing to mother, others may associated with significant fetal risk.

show abstract

Specific Pruritic Diseases of Pregnancy

Cited by 137 publications

References 26 publications

Pregnancy outcomes of women with pruritus, normal bile salts and liver enzymes: a case control study

Pregnancy outcomes of women with pruritus, normal bile salts and liver enzymes: a case control study

Polymorphic eruption of pregnancy and herpes gestationis: comparison of granulated cell proteins in tissue and serum

Dermatological Diseases During Pregnancy

Contact Info

Product

Resources

About